intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. (Gene Ontology, GO_0070059)
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27 genes participating in the intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
ATF4 activating transcription factor 4
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
BAG6 BCL2-associated athanogene 6
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BRSK2 BR serine/threonine kinase 2
CASP12 caspase 12 (gene/pseudogene)
CASP4 caspase 4, apoptosis-related cysteine peptidase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
DAB2IP DAB2 interacting protein
DDIT3 DNA-damage-inducible transcript 3
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ERN1 endoplasmic reticulum to nucleus signaling 1
ERN2 endoplasmic reticulum to nucleus signaling 2
ERO1L ERO1-like (S. cerevisiae)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
PML promyelocytic leukemia
SELK selenoprotein K
TMBIM6 transmembrane BAX inhibitor motif containing 6
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRAF2 TNF receptor-associated factor 2
TRIB3 tribbles pseudokinase 3
UBE2K ubiquitin-conjugating enzyme E2K