intrinsic apoptotic signaling pathway Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). (Gene Ontology, GO_0097193)
External Link http://amigo.geneontology.org/amigo/term/GO:0097193
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Genes

116 genes participating in the intrinsic apoptotic signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
APAF1 apoptotic peptidase activating factor 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATF4 activating transcription factor 4
ATM ATM serine/threonine kinase
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BAD BCL2-associated agonist of cell death
BAG6 BCL2-associated athanogene 6
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BCL2A1 BCL2-related protein A1
BCL2L1 BCL2-like 1
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L2 BCL2-like 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BOK BCL2-related ovarian killer
BRCA1 breast cancer 1, early onset
BRSK2 BR serine/threonine kinase 2
CARD8 caspase recruitment domain family, member 8
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CD24 CD24 molecule
CDPF1 cysteine-rich, DPF motif domain containing 1
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHEK2 checkpoint kinase 2
CIDEB cell death-inducing DFFA-like effector b
CLU clusterin
CNRIP1 cannabinoid receptor interacting protein 1
CUL1 cullin 1
CUL2 cullin 2
CUL3 cullin 3
CUL4A cullin 4A
CUL5 cullin 5
CYCS cytochrome c, somatic
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAB2IP DAB2 interacting protein
DDIT3 DNA-damage-inducible transcript 3
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DIABLO diablo, IAP-binding mitochondrial protein
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
E2F1 E2F transcription factor 1
EPHA2 EPH receptor A2
ERN1 endoplasmic reticulum to nucleus signaling 1
ERN2 endoplasmic reticulum to nucleus signaling 2
ERO1A endoplasmic reticulum oxidoreductase 1 alpha
FHIT fragile histidine triad
FNIP2 folliculin interacting protein 2
GSKIP GSK3B interacting protein
HIC1 hypermethylated in cancer 1
HINT1 histidine triad nucleotide binding protein 1
HIP1R huntingtin interacting protein 1 related
HIPK2 homeodomain interacting protein kinase 2
HSPE1 heat shock 10kDa protein 1
HTRA2 HtrA serine peptidase 2
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFI27L1 interferon, alpha-inducible protein 27-like 1
IFI27L2 interferon, alpha-inducible protein 27-like 2
IFI6 interferon, alpha-inducible protein 6
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JMY junction mediating and regulatory protein, p53 cofactor
LAPTM5 lysosomal protein transmembrane 5
LGALS12 lectin, galactoside-binding, soluble, 12
LOC122513141 ring finger protein-like
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MCL1 myeloid cell leukemia 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOAP1 modulator of apoptosis 1
MSH6 mutS homolog 6
MYBBP1A MYB binding protein (P160) 1a
NLRP1 NLR family, pyrin domain containing 1
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PDPK1 3-phosphoinositide dependent protein kinase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PML promyelocytic leukemia
POU4F1 POU class 4 homeobox 1
POU4F2 POU class 4 homeobox 2
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKCD protein kinase C, delta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRODH proline dehydrogenase (oxidase) 1
PYCARD PYD and CARD domain containing
QRICH1 glutamine-rich 1
REXO2 RNA exonuclease 2
RNF186 ring finger protein 186
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SCN2A sodium channel, voltage gated, type II alpha subunit
SELENOK selenoprotein K
SIVA1 SIVA1, apoptosis-inducing factor
STK11 serine/threonine kinase 11
STK24 serine/threonine kinase 24
TANK TRAF family member-associated NFKB activator
TMEM117 transmembrane protein 117
TMEM238L transmembrane protein 238 like
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TP73 tumor protein p73
TRIB3 tribbles pseudokinase 3
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
ZNF385B zinc finger protein 385B
ZNF622 zinc finger protein 622