invadopodium Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A cell projection that emerges from the ECM-facing surface of a cell, is enriched in actin and associated cytoskeletal proteins, and displays localized proteolytic activity toward the substrate. (Gene Ontology, GO_0071437)
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Genes

146 proteins co-occuring with the invadopodium cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
CTTN cortactin 2.14788
SH3PXD2B SH3 and PX domains 2B 1.64135
SH3PXD2A SH3 and PX domains 2A 1.53613
FAP fibroblast activation protein, alpha 1.52089
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.51412
MMP14 matrix metallopeptidase 14 (membrane-inserted) 1.4069
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 1.17978
NCK1 NCK adaptor protein 1 1.14239
MMP2 matrix metallopeptidase 2 1.01734
WASL Wiskott-Aldrich syndrome-like 0.945907
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.927483
AFAP1L1 actin filament associated protein 1-like 1 0.891631
CDC42 cell division cycle 42 0.875488
MAPK4 mitogen-activated protein kinase 4 0.830466
MMP9 matrix metallopeptidase 9 0.826336
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.808441
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.799728
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.797436
TRIP10 thyroid hormone receptor interactor 10 0.794687
NOXA1 NADPH oxidase activator 1 0.791022
PXN paxillin 0.783698
PALLD palladin, cytoskeletal associated protein 0.769995
SYNJ2 synaptojanin 2 0.755437
RAB40B RAB40B, member RAS oncogene family 0.748641
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.712351
ZFYVE21 zinc finger, FYVE domain containing 21 0.703507
FNBP1 formin binding protein 1 0.693393
WAS Wiskott-Aldrich syndrome 0.638005
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 0.611625
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 0.602331
NOX1 NADPH oxidase 1 0.598117
ARF6 ADP-ribosylation factor 6 0.596855
FSCN1 fascin actin-bundling protein 1 0.592652
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 0.591812
DUOX1 dual oxidase 1 0.58134
STX12 syntaxin 12 0.551012
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.550599
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 0.533309
LOX lysyl oxidase 0.528388
NOXO1 NADPH oxidase organizer 1 0.526341
CSK c-src tyrosine kinase 0.523067
EGFR epidermal growth factor receptor 0.510418
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 0.502288
SPATA13 spermatogenesis associated 13 0.491348
RCC2 regulator of chromosome condensation 2 0.490539
INPPL1 inositol polyphosphate phosphatase-like 1 0.487711
LPAR4 lysophosphatidic acid receptor 4 0.47844
DCC DCC netrin 1 receptor 0.478038
CD44 CD44 molecule (Indian blood group) 0.476429
RLN2 relaxin 2 0.472813
CAV1 caveolin 1, caveolae protein, 22kDa 0.468802
GMPR guanosine monophosphate reductase 0.4672
AMOTL2 angiomotin like 2 0.463997
DPP4 dipeptidyl-peptidase 4 0.454418
CALD1 caldesmon 1 0.453621
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 0.453621
FN1 fibronectin 1 0.450438
RALBP1 ralA binding protein 1 0.43617
WASH7P WAS protein family homolog 7 pseudogene 0.422389
WASH6P WAS protein family homolog 6 pseudogene 0.41886
ADAM12 ADAM metallopeptidase domain 12 0.417685
WASH1 WAS protein family homolog 1 0.41612
TM4SF5 transmembrane 4 L six family member 5 0.415728
MMP7 matrix metallopeptidase 7 0.413382
ABI1 abl-interactor 1 0.412992
DNM2 dynamin 2 0.404804
TIMP2 TIMP metallopeptidase inhibitor 2 0.402859
MYO10 myosin X 0.402081
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.392775
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 0.392388
LAMB1 laminin, beta 1 0.379276
LMLN leishmanolysin-like (metallopeptidase M8 family) 0.378122
HBEGF heparin-binding EGF-like growth factor 0.374283
BATF basic leucine zipper transcription factor, ATF-like 0.370833
EXOC7 exocyst complex component 7 0.368536
PLEK pleckstrin 0.364713
CDCP1 CUB domain containing protein 1 0.358228
GAB1 GRB2-associated binding protein 1 0.354422
MMP25 matrix metallopeptidase 25 0.349105
LPAR1 lysophosphatidic acid receptor 1 0.347208
IGF2 insulin-like growth factor 2 0.341151
FGD1 FYVE, RhoGEF and PH domain containing 1 0.339639
HDAC6 histone deacetylase 6 0.333602
WASF3 WAS protein family, member 3 0.330213
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.329084
MMP13 matrix metallopeptidase 13 0.327581
VCL vinculin 0.325327
TWIST1 twist family bHLH transcription factor 1 0.321575
ARHGAP35 Rho GTPase activating protein 35 0.319328
CORO1C coronin, actin binding protein, 1C 0.316334
VAMP7 vesicle-associated membrane protein 7 0.309613
GRB2 growth factor receptor-bound protein 2 0.308867
CDKN2A cyclin-dependent kinase inhibitor 2A 0.306632
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.30626
CSF1 colony stimulating factor 1 (macrophage) 0.298826
PTEN phosphatase and tensin homolog 0.298084
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.282189
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.280716
MAPK7 mitogen-activated protein kinase 7 0.278509
DUOX2 dual oxidase 2 0.276671
AKR1C4 aldo-keto reductase family 1, member C4 0.274835
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.267139
MMP19 matrix metallopeptidase 19 0.265677
SVIL supervillin 0.258016
PODXL podocalyxin-like 0.245323
VASP vasodilator-stimulated phosphoprotein 0.244601
WDR1 WD repeat domain 1 0.242797
NCK2 NCK adaptor protein 2 0.242076
ERBB2 erb-b2 receptor tyrosine kinase 2 0.238837
FHOD1 formin homology 2 domain containing 1 0.236683
BTG2 BTG family, member 2 0.230245
EREG epiregulin 0.229176
TACSTD2 tumor-associated calcium signal transducer 2 0.224913
FLII flightless I homolog (Drosophila) 0.223497
DAAM1 dishevelled associated activator of morphogenesis 1 0.218563
KRAS Kirsten rat sarcoma viral oncogene homolog 0.208137
NOX3 NADPH oxidase 3 0.207451
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.198991
RALB v-ral simian leukemia viral oncogene homolog B 0.19601
BSG basigin (Ok blood group) 0.193394
MMP1 matrix metallopeptidase 1 0.192746
PKN1 protein kinase N1 0.189222
CRK v-crk avian sarcoma virus CT10 oncogene homolog 0.18516
SMAD4 SMAD family member 4 0.182122
VAV3 vav 3 guanine nucleotide exchange factor 0.182122
PTK7 protein tyrosine kinase 7 (inactive) 0.179167
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.17687
SSH1 slingshot protein phosphatase 1 0.174911
ARF5 ADP-ribosylation factor 5 0.172735
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.172735
VAMP4 vesicle-associated membrane protein 4 0.171149
TIMP4 TIMP metallopeptidase inhibitor 4 0.170371
AMPH amphiphysin 0.168349
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.168101
TNS1 tensin 1 0.167611
ERBB3 erb-b2 receptor tyrosine kinase 3 0.167611
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.165697
PARVA parvin, alpha 0.162763
VANGL2 VANGL planar cell polarity protein 2 0.16233
SNAP23 synaptosomal-associated protein, 23kDa 0.160658
RAP1B RAP1B, member of RAS oncogene family 0.159658
S100P S100 calcium binding protein P 0.157943
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.157039
VAV1 vav 1 guanine nucleotide exchange factor 0.156863
EPGN epithelial mitogen 0.156688
LGMN legumain 0.156513