ionomycin-871 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the ionomycin-871 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AASS aminoadipate-semialdehyde synthase
ACE angiotensin I converting enzyme
ADAM22 ADAM metallopeptidase domain 22
ANG angiogenin, ribonuclease, RNase A family, 5
ANKRD7 ankyrin repeat domain 7
APOE apolipoprotein E
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ARMCX4 armadillo repeat containing, X-linked 4
ATF6 activating transcription factor 6
BAZ1B bromodomain adjacent to zinc finger domain, 1B
C7ORF26 chromosome 7 open reading frame 26
CADM3 cell adhesion molecule 3
CALD1 caldesmon 1
CALR calreticulin
CCDC69 coiled-coil domain containing 69
CD96 CD96 molecule
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLEC10A C-type lectin domain family 10, member A
COL2A1 collagen, type II, alpha 1
COL6A1 collagen, type VI, alpha 1
CRH corticotropin releasing hormone
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
CTBS chitobiase, di-N-acetyl-
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
DACH1 dachshund family transcription factor 1
DDIT3 DNA-damage-inducible transcript 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EAF2 ELL associated factor 2
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ERN2 endoplasmic reticulum to nucleus signaling 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F3 coagulation factor III (thromboplastin, tissue factor)
FKBP14 FK506 binding protein 14, 22 kDa
FRMPD1 FERM and PDZ domain containing 1
GPR107 G protein-coupled receptor 107
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HOXD13 homeobox D13
HSPA13 heat shock protein 70kDa family, member 13
IL17RC interleukin 17 receptor C
IL6ST interleukin 6 signal transducer
INHBE inhibin, beta E
IRAK3 interleukin-1 receptor-associated kinase 3
IRF6 interferon regulatory factor 6
ISG20 interferon stimulated exonuclease gene 20kDa
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB5 integrin, beta 5
KRT12 keratin 12, type I
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK8 mitogen-activated protein kinase 8
MARS methionyl-tRNA synthetase
MED25 mediator complex subunit 25
MINK1 misshapen-like kinase 1
MSL3 male-specific lethal 3 homolog (Drosophila)
MT1H metallothionein 1H
NEK11 NIMA-related kinase 11
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OR2J2 olfactory receptor, family 2, subfamily J, member 2
OSBP2 oxysterol binding protein 2
PARVB parvin, beta
PAX8 paired box 8
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLA2G3 phospholipase A2, group III
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRSS16 protease, serine, 16 (thymus)
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PTK6 protein tyrosine kinase 6
RAP2B RAP2B, member of RAS oncogene family
RARA retinoic acid receptor, alpha
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFPL1 ret finger protein-like 1
RGS10 regulator of G-protein signaling 10
SAA3P serum amyloid A3 pseudogene
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SIM2 single-minded family bHLH transcription factor 2
SLC16A4 solute carrier family 16, member 4
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SMC1A structural maintenance of chromosomes 1A
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STX5 syntaxin 5
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TM2D1 TM2 domain containing 1
TMED7 transmembrane emp24 protein transport domain containing 7
TMEM39A transmembrane protein 39A
TRIM2 tripartite motif containing 2
UBQLN4 ubiquilin 4
ZNF165 zinc finger protein 165
ZNF551 zinc finger protein 551
ZNF75D zinc finger protein 75D
ZNF814 zinc finger protein 814
ZNF816 zinc finger protein 816

decreased expression

Symbol Name
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7
ACSS3 acyl-CoA synthetase short-chain family member 3
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADCY6 adenylate cyclase 6
AKAP12 A kinase (PRKA) anchor protein 12
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ANKZF1 ankyrin repeat and zinc finger domain containing 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BICD1 bicaudal D homolog 1 (Drosophila)
C1ORF112 chromosome 1 open reading frame 112
C5 complement component 5
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHST10 carbohydrate sulfotransferase 10
CLSPN claspin
CPPED1 calcineurin-like phosphoesterase domain containing 1
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DHCR24 24-dehydrocholesterol reductase
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
EFCAB2 EF-hand calcium binding domain 2
F8 coagulation factor VIII, procoagulant component
FKBP10 FK506 binding protein 10, 65 kDa
FMO4 flavin containing monooxygenase 4
FRS2 fibroblast growth factor receptor substrate 2
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPATCH1 G patch domain containing 1
GPR27 G protein-coupled receptor 27
GRHL2 grainyhead-like 2 (Drosophila)
H2AFY2 H2A histone family, member Y2
HDAC4 histone deacetylase 4
HOXC10 homeobox C10
HSPA1L heat shock 70kDa protein 1-like
IL10RB interleukin 10 receptor, beta
ING3 inhibitor of growth family, member 3
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KAT2A K(lysine) acetyltransferase 2A
KCNK15 potassium channel, two pore domain subfamily K, member 15
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KLHL2 kelch-like family member 2
LAMA5 laminin, alpha 5
LIN7A lin-7 homolog A (C. elegans)
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LZTR1 leucine-zipper-like transcription regulator 1
MBOAT2 membrane bound O-acyltransferase domain containing 2
MFSD12 major facilitator superfamily domain containing 12
MIS18BP1 MIS18 binding protein 1
MMP9 matrix metallopeptidase 9
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NLRX1 NLR family member X1
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PARD6A par-6 family cell polarity regulator alpha
PARP16 poly (ADP-ribose) polymerase family, member 16
PCBP4 poly(rC) binding protein 4
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLIN3 perilipin 3
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RBL1 retinoblastoma-like 1
RBM42 RNA binding motif protein 42
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SCML2 sex comb on midleg-like 2 (Drosophila)
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SESN1 sestrin 1
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC41A3 solute carrier family 41, member 3
SMCO4 single-pass membrane protein with coiled-coil domains 4
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SPINK4 serine peptidase inhibitor, Kazal type 4
SSBP3 single stranded DNA binding protein 3
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STBD1 starch binding domain 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
THAP7 THAP domain containing 7
TMEM104 transmembrane protein 104
TMEM2 transmembrane protein 2
TRAPPC2 trafficking protein particle complex 2
TRNAU1AP tRNA selenocysteine 1 associated protein 1
UBXN6 UBX domain protein 6
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
VEGFC vascular endothelial growth factor C
VGF VGF nerve growth factor inducible
WDR19 WD repeat domain 19
YEATS4 YEATS domain containing 4
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBTB39 zinc finger and BTB domain containing 39
ZNF141 zinc finger protein 141
ZNF273 zinc finger protein 273
ZNF669 zinc finger protein 669
ZNF767P zinc finger family member 767, pseudogene