ionomycin Gene Set

Dataset LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category transcriptomics
Type small molecule perturbation
Description A very long-chain fatty acid that is docosa-10,16-dienoic acid which is substituted by methyl groups at positions 4, 6, 8, 12, 14, 18 and 20, by hydroxy groups at positions 11, 19 and 21, and by a (2',5-dimethyloctahydro-2,2'-bifuran-5-yl)ethanol group at position 21. An ionophore produced by Streptomyces conglobatus, it is used in research to raise the intracellular level of Ca(2+) and as a research tool to understand Ca(2+) transport across biological membranes. (Chemical Entities of Biological Interest Ontology, CHEBI_63954)
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Genes

9 genes differentially expressed following the ionomycin small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
KLHDC2 kelch domain containing 2 4.434
USP6NL USP6 N-terminal like 3.67327
SNAP25 synaptosomal-associated protein, 25kDa 3.59299
ARF6 ADP-ribosylation factor 6 3.09526
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 3.01584
IER5 immediate early response 5 3.01471

decreased expression

Symbol Name Standardized Value
TSPYL4 TSPY-like 4 -3.54241
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.49975
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha -3.37761