ioxaglic acid-2966 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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191 genes differentially expressed following the ioxaglic acid-2966 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADAM22 ADAM metallopeptidase domain 22
ADGRG2 adhesion G protein-coupled receptor G2
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARMCX4 armadillo repeat containing, X-linked 4
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAHCC1 BAH domain and coiled-coil containing 1
BIN1 bridging integrator 1
C17ORF53 chromosome 17 open reading frame 53
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CCDC170 coiled-coil domain containing 170
CCDC85B coiled-coil domain containing 85B
CCDC9 coiled-coil domain containing 9
CD70 CD70 molecule
CDC14B cell division cycle 14B
CFAP45 cilia and flagella associated protein 45
COL4A2 collagen, type IV, alpha 2
CTNND2 catenin (cadherin-associated protein), delta 2
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
EFNA5 ephrin-A5
ERMAP erythroblast membrane-associated protein (Scianna blood group)
EXD3 exonuclease 3'-5' domain containing 3
EXPH5 exophilin 5
F12 coagulation factor XII (Hageman factor)
FAM127A family with sequence similarity 127, member A
FSCN1 fascin actin-bundling protein 1
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GAS8 growth arrest-specific 8
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GSPT1 G1 to S phase transition 1
HIC2 hypermethylated in cancer 2
HIST1H1D histone cluster 1, H1d
HTRA2 HtrA serine peptidase 2
IMPG2 interphotoreceptor matrix proteoglycan 2
INPP5J inositol polyphosphate-5-phosphatase J
KHSRP KH-type splicing regulatory protein
KIF3C kinesin family member 3C
KLHL25 kelch-like family member 25
LAD1 ladinin 1
LEF1 lymphoid enhancer-binding factor 1
MAST2 microtubule associated serine/threonine kinase 2
MAST4 microtubule associated serine/threonine kinase family member 4
MID1 midline 1
MINK1 misshapen-like kinase 1
MKL1 megakaryoblastic leukemia (translocation) 1
MLH3 mutL homolog 3
MOGS mannosyl-oligosaccharide glucosidase
MRAS muscle RAS oncogene homolog
MREG melanoregulin
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MZF1 myeloid zinc finger 1
NR2C1 nuclear receptor subfamily 2, group C, member 1
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4
PADI2 peptidyl arginine deiminase, type II
PDGFB platelet-derived growth factor beta polypeptide
PDLIM2 PDZ and LIM domain 2 (mystique)
PHF1 PHD finger protein 1
PHF3 PHD finger protein 3
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PRKCA protein kinase C, alpha
PTAFR platelet-activating factor receptor
RET ret proto-oncogene
RGS12 regulator of G-protein signaling 12
RGS19 regulator of G-protein signaling 19
ROM1 retinal outer segment membrane protein 1
RPL13P5 ribosomal protein L13 pseudogene 5
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SLN sarcolipin
SMG7 SMG7 nonsense mediated mRNA decay factor
SRSF7 serine/arginine-rich splicing factor 7
ST14 suppression of tumorigenicity 14 (colon carcinoma)
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STK11 serine/threonine kinase 11
TBRG4 transforming growth factor beta regulator 4
TBXA2R thromboxane A2 receptor
TEAD4 TEA domain family member 4
TMCC1 transmembrane and coiled-coil domain family 1
TMEM2 transmembrane protein 2
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TPM1 tropomyosin 1 (alpha)
TRMT61A tRNA methyltransferase 61A
TUBA4B tubulin, alpha 4b
UBQLN4 ubiquilin 4
UBTF upstream binding transcription factor, RNA polymerase I
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
USP46 ubiquitin specific peptidase 46
WWTR1 WW domain containing transcription regulator 1
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF235 zinc finger protein 235
ZNF34 zinc finger protein 34
ZNF609 zinc finger protein 609
ZNF710 zinc finger protein 710
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
AACS acetoacetyl-CoA synthetase
AMIGO2 adhesion molecule with Ig-like domain 2
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARID5A AT rich interactive domain 5A (MRF1-like)
C17ORF75 chromosome 17 open reading frame 75
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CGREF1 cell growth regulator with EF-hand domain 1
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNMBP dynamin binding protein
DOCK4 dedicator of cytokinesis 4
DYM dymeclin
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGR3 early growth response 3
EMILIN2 elastin microfibril interfacer 2
ERF Ets2 repressor factor
ETV4 ets variant 4
FAM188A family with sequence similarity 188, member A
FAM192A family with sequence similarity 192, member A
FBRS fibrosin
FKBPL FK506 binding protein like
GBP2 guanylate binding protein 2, interferon-inducible
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GMPPB GDP-mannose pyrophosphorylase B
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPALPP1 GPALPP motifs containing 1
GRAMD1B GRAM domain containing 1B
GSTM2 glutathione S-transferase mu 2 (muscle)
HDAC4 histone deacetylase 4
HIST1H2BN histone cluster 1, H2bn
HP haptoglobin
HS1BP3 HCLS1 binding protein 3
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
IL4R interleukin 4 receptor
ISG20 interferon stimulated exonuclease gene 20kDa
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
JADE3 jade family PHD finger 3
KAT2A K(lysine) acetyltransferase 2A
KIAA0754 KIAA0754
KIF1B kinesin family member 1B
MAGEB2 melanoma antigen family B2
MANSC1 MANSC domain containing 1
MED9 mediator complex subunit 9
MST1 macrophage stimulating 1
MVD mevalonate (diphospho) decarboxylase
MX1 MX dynamin-like GTPase 1
NT5E 5'-nucleotidase, ecto (CD73)
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PAQR4 progestin and adipoQ receptor family member IV
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLAG1 pleiomorphic adenoma gene 1
PMCH pro-melanin-concentrating hormone
PNMA1 paraneoplastic Ma antigen 1
PNOC prepronociceptin
POMT1 protein-O-mannosyltransferase 1
POMZP3 POM121 and ZP3 fusion
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme
PRAF2 PRA1 domain family, member 2
PRKX protein kinase, X-linked
PTCD2 pentatricopeptide repeat domain 2
PTH2R parathyroid hormone 2 receptor
RPAIN RPA interacting protein
RPL23AP32 ribosomal protein L23a pseudogene 32
RPL23AP7 ribosomal protein L23a pseudogene 7
RUSC2 RUN and SH3 domain containing 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A4 solute carrier family 16, member 4
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SP1 Sp1 transcription factor
STAG3 stromal antigen 3
STBD1 starch binding domain 1
STON1 stonin 1
STRN striatin, calmodulin binding protein
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TCEA2 transcription elongation factor A (SII), 2
TCTA T-cell leukemia translocation altered
TMEM184C transmembrane protein 184C
TMEM254 transmembrane protein 254
TRPS1 trichorhinophalangeal syndrome I
TUBB2A tubulin, beta 2A class IIa
UPP1 uridine phosphorylase 1
USB1 U6 snRNA biogenesis 1
WDR60 WD repeat domain 60
ZNF212 zinc finger protein 212
ZNF230 zinc finger protein 230
ZNF32 zinc finger protein 32
ZNF529 zinc finger protein 529