ioxaglic acid-7470 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the ioxaglic acid-7470 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ANGPTL2 angiopoietin-like 2
ANKRD6 ankyrin repeat domain 6
ANPEP alanyl (membrane) aminopeptidase
APOM apolipoprotein M
AQP3 aquaporin 3 (Gill blood group)
ARNT aryl hydrocarbon receptor nuclear translocator
BTD biotinidase
C5 complement component 5
C5ORF45 chromosome 5 open reading frame 45
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CCDC64 coiled-coil domain containing 64
CD302 CD302 molecule
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CFLAR CASP8 and FADD-like apoptosis regulator
CHM choroideremia (Rab escort protein 1)
CLEC11A C-type lectin domain family 11, member A
CSF1 colony stimulating factor 1 (macrophage)
CTAGE5 CTAGE family, member 5
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CXCR4 chemokine (C-X-C motif) receptor 4
DST dystonin
DVL3 dishevelled segment polarity protein 3
ECE1 endothelin converting enzyme 1
ESR1 estrogen receptor 1
EVA1B eva-1 homolog B (C. elegans)
FAM65A family with sequence similarity 65, member A
FH fumarate hydratase
FLOT1 flotillin 1
GAB1 GRB2-associated binding protein 1
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GM2A GM2 ganglioside activator
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GSDMB gasdermin B
GSPT1 G1 to S phase transition 1
HIPK2 homeodomain interacting protein kinase 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LRP2 low density lipoprotein receptor-related protein 2
LRRC41 leucine rich repeat containing 41
MAP4 microtubule-associated protein 4
MBD2 methyl-CpG binding domain protein 2
MCF2L MCF.2 cell line derived transforming sequence-like
MIIP migration and invasion inhibitory protein
MKL1 megakaryoblastic leukemia (translocation) 1
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MTAP methylthioadenosine phosphorylase
MVK mevalonate kinase
MYH14 myosin, heavy chain 14, non-muscle
NAAA N-acylethanolamine acid amidase
NF2 neurofibromin 2 (merlin)
NOX1 NADPH oxidase 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NRP2 neuropilin 2
NRSN2 neurensin 2
NUP62CL nucleoporin 62kDa C-terminal like
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCNX pecanex homolog (Drosophila)
PDCD6 programmed cell death 6
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRDX2 peroxiredoxin 2
PSG9 pregnancy specific beta-1-glycoprotein 9
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PTRF polymerase I and transcript release factor
QTRT1 queuine tRNA-ribosyltransferase 1
RABGAP1L RAB GTPase activating protein 1-like
RANBP1 RAN binding protein 1
RANBP3 RAN binding protein 3
RARA retinoic acid receptor, alpha
RNFT2 ring finger protein, transmembrane 2
RPL10 ribosomal protein L10
RRP1 ribosomal RNA processing 1
RYR2 ryanodine receptor 2 (cardiac)
SCN1B sodium channel, voltage gated, type I beta subunit
SIRT3 sirtuin 3
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SPN sialophorin
SRF serum response factor (c-fos serum response element-binding transcription factor)
TGFBR1 transforming growth factor, beta receptor 1
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TK2 thymidine kinase 2, mitochondrial
TOP3A topoisomerase (DNA) III alpha
TP53I11 tumor protein p53 inducible protein 11
TREX1 three prime repair exonuclease 1
TRPM4 transient receptor potential cation channel, subfamily M, member 4
VEGFB vascular endothelial growth factor B
VPS13B vacuolar protein sorting 13 homolog B (yeast)
WDR25 WD repeat domain 25
WLS wntless Wnt ligand secretion mediator
ZBTB14 zinc finger and BTB domain containing 14
ZNF236 zinc finger protein 236
ZNF747 zinc finger protein 747
ZNF770 zinc finger protein 770

decreased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ADCK3 aarF domain containing kinase 3
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ATF7IP2 activating transcription factor 7 interacting protein 2
BCL9 B-cell CLL/lymphoma 9
C11ORF30 chromosome 11 open reading frame 30
C14ORF132 chromosome 14 open reading frame 132
C1ORF115 chromosome 1 open reading frame 115
C2ORF44 chromosome 2 open reading frame 44
C7ORF43 chromosome 7 open reading frame 43
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CENPQ centromere protein Q
CIDEC cell death-inducing DFFA-like effector c
CISH cytokine inducible SH2-containing protein
DACH1 dachshund family transcription factor 1
DCAF17 DDB1 and CUL4 associated factor 17
DMTN dematin actin binding protein
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNM1 dynamin 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EDAR ectodysplasin A receptor
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EFNA3 ephrin-A3
EFNA4 ephrin-A4
FAM184A family with sequence similarity 184, member A
FAM188A family with sequence similarity 188, member A
FAM53B family with sequence similarity 53, member B
FBXO31 F-box protein 31
FER fer (fps/fes related) tyrosine kinase
GADD45G growth arrest and DNA-damage-inducible, gamma
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPX2 glutathione peroxidase 2
HDAC11 histone deacetylase 11
HIRA histone cell cycle regulator
HIST1H4F histone cluster 1, H4f
HMOX1 heme oxygenase 1
HPN hepsin
IL15RA interleukin 15 receptor, alpha
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KDM7A lysine (K)-specific demethylase 7A
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MBNL3 muscleblind-like splicing regulator 3
MCOLN1 mucolipin 1
MCOLN3 mucolipin 3
MEIS2 Meis homeobox 2
MFSD12 major facilitator superfamily domain containing 12
MVD mevalonate (diphospho) decarboxylase
MXD3 MAX dimerization protein 3
MYO1F myosin IF
N4BP3 NEDD4 binding protein 3
NBEAL2 neurobeachin-like 2
NDE1 nudE neurodevelopment protein 1
NDRG4 NDRG family member 4
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PARD6A par-6 family cell polarity regulator alpha
PCDHB3 protocadherin beta 3
PGP phosphoglycolate phosphatase
PKN1 protein kinase N1
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PROS1 protein S (alpha)
PTCD2 pentatricopeptide repeat domain 2
PTDSS2 phosphatidylserine synthase 2
PTTG3P pituitary tumor-transforming 3, pseudogene
RABL6 RAB, member RAS oncogene family-like 6
RASA2 RAS p21 protein activator 2
RCOR3 REST corepressor 3
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
SAMHD1 SAM domain and HD domain 1
SETD1B SET domain containing 1B
SMG9 SMG9 nonsense mediated mRNA decay factor
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SOX3 SRY (sex determining region Y)-box 3
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STARD13 StAR-related lipid transfer (START) domain containing 13
SUN2 Sad1 and UNC84 domain containing 2
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TMEM209 transmembrane protein 209
TMPRSS3 transmembrane protease, serine 3
TMUB2 transmembrane and ubiquitin-like domain containing 2
USB1 U6 snRNA biogenesis 1
VEGFC vascular endothelial growth factor C
VGF VGF nerve growth factor inducible
ZNF16 zinc finger protein 16
ZNF212 zinc finger protein 212
ZNF254 zinc finger protein 254
ZNF286A zinc finger protein 286A
ZNF35 zinc finger protein 35
ZNF668 zinc finger protein 668
ZNF701 zinc finger protein 701
ZNF778 zinc finger protein 778