iproniazid-2125 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the iproniazid-2125 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRE2 adhesion G protein-coupled receptor E2
ADRBK1 adrenergic, beta, receptor kinase 1
AHNAK AHNAK nucleoprotein
AKAP8L A kinase (PRKA) anchor protein 8-like
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANGPTL2 angiopoietin-like 2
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ATXN7L1 ataxin 7-like 1
BATF3 basic leucine zipper transcription factor, ATF-like 3
BMP4 bone morphogenetic protein 4
CD300A CD300a molecule
CDC25C cell division cycle 25C
CNTN5 contactin 5
CNTNAP2 contactin associated protein-like 2
CPT1A carnitine palmitoyltransferase 1A (liver)
CYB561 cytochrome b561
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DCAF4 DDB1 and CUL4 associated factor 4
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
EGFL7 EGF-like-domain, multiple 7
FMOD fibromodulin
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXN3 forkhead box N3
GABARAPL1 GABA(A) receptor-associated protein like 1
GAL3ST4 galactose-3-O-sulfotransferase 4
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GMEB1 glucocorticoid modulatory element binding protein 1
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble)
GRK5 G protein-coupled receptor kinase 5
HN1L hematological and neurological expressed 1-like
HOOK1 hook microtubule-tethering protein 1
HOXA11 homeobox A11
HOXC11 homeobox C11
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI6 interferon, alpha-inducible protein 6
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IKZF5 IKAROS family zinc finger 5 (Pegasus)
INCENP inner centromere protein antigens 135/155kDa
JUN jun proto-oncogene
KDM5A lysine (K)-specific demethylase 5A
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LMF1 lipase maturation factor 1
MAP9 microtubule-associated protein 9
MAPK8 mitogen-activated protein kinase 8
MGC12488
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MRPS12 mitochondrial ribosomal protein S12
MUC3B mucin 3B, cell surface associated
MYH11 myosin, heavy chain 11, smooth muscle
MYL5 myosin, light chain 5, regulatory
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR5A2 nuclear receptor subfamily 5, group A, member 2
PARM1 prostate androgen-regulated mucin-like protein 1
PDE12 phosphodiesterase 12
PDGFA platelet-derived growth factor alpha polypeptide
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
PKP3 plakophilin 3
PLXND1 plexin D1
POLL polymerase (DNA directed), lambda
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRRC2C proline-rich coiled-coil 2C
PXMP4 peroxisomal membrane protein 4, 24kDa
RBL2 retinoblastoma-like 2
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RGS14 regulator of G-protein signaling 14
RGS17 regulator of G-protein signaling 17
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
SCARB1 scavenger receptor class B, member 1
SOX15 SRY (sex determining region Y)-box 15
SPIN1 spindlin 1
SPRED2 sprouty-related, EVH1 domain containing 2
STK11 serine/threonine kinase 11
STK4 serine/threonine kinase 4
STX2 syntaxin 2
STX6 syntaxin 6
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYCP2 synaptonemal complex protein 2
TBC1D30 TBC1 domain family, member 30
TCTN1 tectonic family member 1
TLR2 toll-like receptor 2
TMC7 transmembrane channel-like 7
TMPRSS15 transmembrane protease, serine 15
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRIM23 tripartite motif containing 23
UBE2I ubiquitin-conjugating enzyme E2I
USP12 ubiquitin specific peptidase 12
USP27X ubiquitin specific peptidase 27, X-linked
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
ZNF287 zinc finger protein 287
ZNF358 zinc finger protein 358
ZNF428 zinc finger protein 428
ZNF43 zinc finger protein 43
ZNF747 zinc finger protein 747
ZNF93 zinc finger protein 93

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
AARSD1 alanyl-tRNA synthetase domain containing 1
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADCY6 adenylate cyclase 6
AMPD2 adenosine monophosphate deaminase 2
APH1B APH1B gamma secretase subunit
ARHGAP11A Rho GTPase activating protein 11A
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ATF7IP2 activating transcription factor 7 interacting protein 2
CAMTA2 calmodulin binding transcription activator 2
CDK3 cyclin-dependent kinase 3
CEP85 centrosomal protein 85kDa
CLCN5 chloride channel, voltage-sensitive 5
CLDN15 claudin 15
CLEC2B C-type lectin domain family 2, member B
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COBL cordon-bleu WH2 repeat protein
CRELD1 cysteine-rich with EGF-like domains 1
DGKD diacylglycerol kinase, delta 130kDa
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DPY19L2P2 DPY19L2 pseudogene 2
ERF Ets2 repressor factor
F3 coagulation factor III (thromboplastin, tissue factor)
FAM131A family with sequence similarity 131, member A
FKBP10 FK506 binding protein 10, 65 kDa
FURIN furin (paired basic amino acid cleaving enzyme)
GCAT glycine C-acetyltransferase
GID4 GID complex subunit 4
GLCE glucuronic acid epimerase
GNL1 guanine nucleotide binding protein-like 1
GPR1 G protein-coupled receptor 1
GUSBP3 glucuronidase, beta pseudogene 3
HHEX hematopoietically expressed homeobox
HIRA histone cell cycle regulator
HMOX1 heme oxygenase 1
HS1BP3 HCLS1 binding protein 3
IFT54 intraflagellar transport 54
IL11RA interleukin 11 receptor, alpha
IL33 interleukin 33
IRAK4 interleukin-1 receptor-associated kinase 4
IRF2 interferon regulatory factor 2
ITGA10 integrin, alpha 10
ITPKB inositol-trisphosphate 3-kinase B
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCTD7 potassium channel tetramerization domain containing 7
KIAA0232 KIAA0232
KIAA0754 KIAA0754
KIAA0894 KIAA0894 protein
LOC257152 uncharacterized LOC257152
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MDN1 MDN1, midasin homolog (yeast)
MICALL2 MICAL-like 2
MTHFSD methenyltetrahydrofolate synthetase domain containing
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NBEAL2 neurobeachin-like 2
NCS1 neuronal calcium sensor 1
NUP62CL nucleoporin 62kDa C-terminal like
NXPE3 neurexophilin and PC-esterase domain family, member 3
OVGP1 oviductal glycoprotein 1, 120kDa
PCOLCE procollagen C-endopeptidase enhancer
PILRB paired immunoglobin-like type 2 receptor beta
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PRICKLE3 prickle homolog 3 (Drosophila)
PRKX protein kinase, X-linked
PRMT7 protein arginine methyltransferase 7
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTPN9 protein tyrosine phosphatase, non-receptor type 9
QSER1 glutamine and serine rich 1
RABL6 RAB, member RAS oncogene family-like 6
RBM14 RNA binding motif protein 14
RBM23 RNA binding motif protein 23
RIN1 Ras and Rab interactor 1
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
SAMD9 sterile alpha motif domain containing 9
SH3BGR SH3 domain binding glutamate-rich protein
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC46A3 solute carrier family 46, member 3
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TBL3 transducin (beta)-like 3
TMBIM1 transmembrane BAX inhibitor motif containing 1
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
USP32 ubiquitin specific peptidase 32
VGLL3 vestigial-like family member 3
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
ZBTB39 zinc finger and BTB domain containing 39
ZC3H12A zinc finger CCCH-type containing 12A
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF107 zinc finger protein 107
ZNF280D zinc finger protein 280D
ZNF606 zinc finger protein 606
ZNF671 zinc finger protein 671
ZW10 zw10 kinetochore protein