iproniazid-5458 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the iproniazid-5458 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACVR1B activin A receptor, type IB
ADGRG1 adhesion G protein-coupled receptor G1
ADORA1 adenosine A1 receptor
AHNAK AHNAK nucleoprotein
ALDOB aldolase B, fructose-bisphosphate
ANKH ANKH inorganic pyrophosphate transport regulator
APC adenomatous polyposis coli
APOE apolipoprotein E
APOH apolipoprotein H (beta-2-glycoprotein I)
ATP10B ATPase, class V, type 10B
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BCL2A1 BCL2-related protein A1
C14ORF79 chromosome 14 open reading frame 79
C3ORF18 chromosome 3 open reading frame 18
CABP2 calcium binding protein 2
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CCL5 chemokine (C-C motif) ligand 5
CDK14 cyclin-dependent kinase 14
CEP295 centrosomal protein 295kDa
CLSTN2 calsyntenin 2
CNGB3 cyclic nucleotide gated channel beta 3
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CTNS cystinosin, lysosomal cystine transporter
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DCAKD dephospho-CoA kinase domain containing
DNALI1 dynein, axonemal, light intermediate chain 1
DOCK5 dedicator of cytokinesis 5
DUSP26 dual specificity phosphatase 26 (putative)
ERN2 endoplasmic reticulum to nucleus signaling 2
FBXO2 F-box protein 2
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FOXD2 forkhead box D2
GAS7 growth arrest-specific 7
GK glycerol kinase
GK3P glycerol kinase 3 pseudogene
GSK3A glycogen synthase kinase 3 alpha
HDAC11 histone deacetylase 11
HDAC7 histone deacetylase 7
HIC2 hypermethylated in cancer 2
HIST1H4E histone cluster 1, H4e
HMGN5 high mobility group nucleosome binding domain 5
HNF1B HNF1 homeobox B
HPX hemopexin
IGFBP3 insulin-like growth factor binding protein 3
IL17RC interleukin 17 receptor C
ITGB4 integrin, beta 4
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
JMJD4 jumonji domain containing 4
KLK13 kallikrein-related peptidase 13
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
MAOB monoamine oxidase B
MIP major intrinsic protein of lens fiber
MOG myelin oligodendrocyte glycoprotein
MUC4 mucin 4, cell surface associated
MYO7A myosin VIIA
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NF1 neurofibromin 1
NPR1 natriuretic peptide receptor 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
OTC ornithine carbamoyltransferase
PARVA parvin, alpha
PCDHGA8 protocadherin gamma subfamily A, 8
PCDHGC3 protocadherin gamma subfamily C, 3
PDE4DIP phosphodiesterase 4D interacting protein
PIGR polymeric immunoglobulin receptor
PPP4R4 protein phosphatase 4, regulatory subunit 4
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRY PTPN13-like, Y-linked
PTMS parathymosin
PTPN7 protein tyrosine phosphatase, non-receptor type 7
PTX3 pentraxin 3, long
RGS5 regulator of G-protein signaling 5
RGS7 regulator of G-protein signaling 7
RORA RAR-related orphan receptor A
RRBP1 ribosome binding protein 1
RUNDC3A RUN domain containing 3A
SH3BP2 SH3-domain binding protein 2
SLAMF1 signaling lymphocytic activation molecule family member 1
SLC35E2 solute carrier family 35, member E2
SLC38A4 solute carrier family 38, member 4
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLMO1 slowmo homolog 1 (Drosophila)
SMR3B submaxillary gland androgen regulated protein 3B
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBC1D22A TBC1 domain family, member 22A
TICAM1 toll-like receptor adaptor molecule 1
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TRIM21 tripartite motif containing 21
TSPAN9 tetraspanin 9
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
VAC14 Vac14 homolog (S. cerevisiae)
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
ZMAT4 zinc finger, matrin-type 4
ZNF750 zinc finger protein 750

decreased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
ACBD4 acyl-CoA binding domain containing 4
ACTL8 actin-like 8
AHDC1 AT hook, DNA binding motif, containing 1
ALPK1 alpha-kinase 1
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARRB1 arrestin, beta 1
ASB9 ankyrin repeat and SOCS box containing 9
ATP7B ATPase, Cu++ transporting, beta polypeptide
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
B9D2 B9 protein domain 2
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BTBD2 BTB (POZ) domain containing 2
C10ORF95 chromosome 10 open reading frame 95
CAPRIN2 caprin family member 2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEMIP cell migration inducing protein, hyaluronan binding
CLGN calmegin
CRY2 cryptochrome circadian clock 2
CST6 cystatin E/M
CUEDC1 CUE domain containing 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DSCAM Down syndrome cell adhesion molecule
ELMO3 engulfment and cell motility 3
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EXD3 exonuclease 3'-5' domain containing 3
EXO5 exonuclease 5
FGF23 fibroblast growth factor 23
FOSL1 FOS-like antigen 1
FURIN furin (paired basic amino acid cleaving enzyme)
GLB1L galactosidase, beta 1-like
GLRA1 glycine receptor, alpha 1
GPNMB glycoprotein (transmembrane) nmb
GSTA4 glutathione S-transferase alpha 4
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BO histone cluster 1, H2bo
HMOX1 heme oxygenase 1
IRF6 interferon regulatory factor 6
ITGA10 integrin, alpha 10
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LHX6 LIM homeobox 6
LIN7B lin-7 homolog B (C. elegans)
LOC100286895 cell division cycle 27 homolog pseudogene
LRP3 low density lipoprotein receptor-related protein 3
MAPKBP1 mitogen-activated protein kinase binding protein 1
MFAP2 microfibrillar-associated protein 2
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRPL52 mitochondrial ribosomal protein L52
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYO1E myosin IE
NES nestin
NKAIN1 Na+/K+ transporting ATPase interacting 1
NPFFR1 neuropeptide FF receptor 1
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSMR oncostatin M receptor
PCDHB8 protocadherin beta 8
PLEKHO1 pleckstrin homology domain containing, family O member 1
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PODNL1 podocan-like 1
PRKCE protein kinase C, epsilon
PSG4 pregnancy specific beta-1-glycoprotein 4
RCAN3 RCAN family member 3
RFXAP regulatory factor X-associated protein
RGS2 regulator of G-protein signaling 2
RNF39 ring finger protein 39
S100A9 S100 calcium binding protein A9
SAYSD1 SAYSVFN motif domain containing 1
SDC3 syndecan 3
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SENP7 SUMO1/sentrin specific peptidase 7
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIX1 SIX homeobox 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STRA6 stimulated by retinoic acid 6
TARP TCR gamma alternate reading frame protein
TBX19 T-box 19
TMEM242 transmembrane protein 242
TMEM45A transmembrane protein 45A
TPST2 tyrosylprotein sulfotransferase 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TUBG2 tubulin, gamma 2
USB1 U6 snRNA biogenesis 1
VASH2 vasohibin 2
VIPR1 vasoactive intestinal peptide receptor 1
WDR91 WD repeat domain 91
ZMAT5 zinc finger, matrin-type 5
ZNF329 zinc finger protein 329
ZNF446 zinc finger protein 446
ZNF747 zinc finger protein 747