irak4 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description interleukin-1 receptor-associated kinase 4|This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 51135)
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Genes

26 genes co-occuring with the biological term irak4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
CD27 CD27 molecule
DCD dermcidin
GAK cyclin G associated kinase
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RAP interleukin 1 receptor accessory protein
IL6 interleukin 6
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK4 interleukin-1 receptor-associated kinase 4
MAL mal, T-cell differentiation protein
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MIR132 microRNA 132
MIR212 microRNA 212
MYD88 myeloid differentiation primary response 88
NCF1 neutrophil cytosolic factor 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
PELI2 pellino E3 ubiquitin protein ligase family member 2
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
UNC93B1 unc-93 homolog B1 (C. elegans)