irf3 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description interferon regulatory factor 3|This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] (NCBI Entrez Gene Database, 3661)
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Genes

83 genes co-occuring with the biological term irf3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADAR adenosine deaminase, RNA-specific
ATF2 activating transcription factor 2
ATF3 activating transcription factor 3
AZI2 5-azacytidine induced 2
B2M beta-2-microglobulin
BAX BCL2-associated X protein
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCL5 chemokine (C-C motif) ligand 5
CD14 CD14 molecule
CREBBP CREB binding protein
CXCL10 chemokine (C-X-C motif) ligand 10
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
E2F1 E2F transcription factor 1
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EP300 E1A binding protein p300
FOXO1 forkhead box O1
GLRX glutaredoxin (thioltransferase)
GSK3B glycogen synthase kinase 3 beta
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HMGA2 high mobility group AT-hook 2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IDO1 indoleamine 2,3-dioxygenase 1
IFIH1 interferon induced with helicase C domain 1
IFN1@ interferon, type 1, cluster
IFNA1 interferon, alpha 1
IFNB1 interferon, beta 1, fibroblast
IFNL1 interferon, lambda 1
IFNL2 interferon, lambda 2
IFNL3 interferon, lambda 3
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL12B interleukin 12B
IL23A interleukin 23, alpha subunit p19
IRF3 interferon regulatory factor 3
IRF4 interferon regulatory factor 4
IRF5 interferon regulatory factor 5
IRF7 interferon regulatory factor 7
IRF8 interferon regulatory factor 8
ISG15 ISG15 ubiquitin-like modifier
JUN jun proto-oncogene
LGALS9 lectin, galactoside-binding, soluble, 9
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK14 mitogen-activated protein kinase 14
MAVS mitochondrial antiviral signaling protein
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MX1 MX dynamin-like GTPase 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NR2C2 nuclear receptor subfamily 2, group C, member 2
PIAS1 protein inhibitor of activated STAT, 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RAB11A RAB11A, member RAS oncogene family
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RIOK3 RIO kinase 3
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RRAS related RAS viral (r-ras) oncogene homolog
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SIKE1 suppressor of IKBKE 1
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SUMO2 small ubiquitin-like modifier 2
SYK spleen tyrosine kinase
TBK1 TANK-binding kinase 1
TICAM1 toll-like receptor adaptor molecule 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TMEM173 transmembrane protein 173
TNF tumor necrosis factor
TP53 tumor protein p53
TREX1 three prime repair exonuclease 1
TRIM21 tripartite motif containing 21
UBE2D1 ubiquitin-conjugating enzyme E2D 1
ZBP1 Z-DNA binding protein 1
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZNF143 zinc finger protein 143