irf5 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description interferon regulatory factor 5|This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Mar 2010] (NCBI Entrez Gene Database, 3663)
Similar Terms
Downloads & Tools

Genes

29 genes co-occuring with the biological term irf5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
BANK1 B-cell scaffold protein with ankyrin repeats 1
BLK BLK proto-oncogene, Src family tyrosine kinase
CD83 CD83 molecule
CHRM3 cholinergic receptor, muscarinic 3
CHUK conserved helix-loop-helix ubiquitous kinase
DEFB1 defensin, beta 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
IFNB1 interferon, beta 1, fibroblast
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL12B interleukin 12B
IL6 interleukin 6
IRF3 interferon regulatory factor 3
IRF4 interferon regulatory factor 4
IRF5 interferon regulatory factor 5
IRF7 interferon regulatory factor 7
MYD88 myeloid differentiation primary response 88
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
PPARG peroxisome proliferator-activated receptor gamma
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT4 signal transducer and activator of transcription 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TLR4 toll-like receptor 4
TLR7 toll-like receptor 7
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TYK2 tyrosine kinase 2
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
XPO1 exportin 1