| Dataset | CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis) |
| Similar Terms | |
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199 genes differentially expressed following the irinotecan-7498 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| ABCF2 | ATP-binding cassette, sub-family F (GCN20), member 2 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta |
| ADM | adrenomedullin |
| AEN | apoptosis enhancing nuclease |
| ALDOC | aldolase C, fructose-bisphosphate |
| AMH | anti-Mullerian hormone |
| ANKRA2 | ankyrin repeat, family A (RFXANK-like), 2 |
| AP5Z1 | adaptor-related protein complex 5, zeta 1 subunit |
| APLP1 | amyloid beta (A4) precursor-like protein 1 |
| ARC | activity-regulated cytoskeleton-associated protein |
| ASB1 | ankyrin repeat and SOCS box containing 1 |
| ASPHD1 | aspartate beta-hydroxylase domain containing 1 |
| ATF3 | activating transcription factor 3 |
| BTG2 | BTG family, member 2 |
| C14ORF79 | chromosome 14 open reading frame 79 |
| CABYR | calcium binding tyrosine-(Y)-phosphorylation regulated |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
| CEL | carboxyl ester lipase |
| CHKB | choline kinase beta |
| CLN8 | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) |
| CSF1 | colony stimulating factor 1 (macrophage) |
| CUZD1 | CUB and zona pellucida-like domains 1 |
| DDIT4 | DNA-damage-inducible transcript 4 |
| DIEXF | digestive organ expansion factor homolog (zebrafish) |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 |
| EGR1 | early growth response 1 |
| EIF5 | eukaryotic translation initiation factor 5 |
| EPHA2 | EPH receptor A2 |
| FDXR | ferredoxin reductase |
| FGFR3 | fibroblast growth factor receptor 3 |
| FILIP1L | filamin A interacting protein 1-like |
| FLCN | folliculin |
| FOSL1 | FOS-like antigen 1 |
| FSCN1 | fascin actin-bundling protein 1 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha |
| GPR87 | G protein-coupled receptor 87 |
| GRIN2C | glutamate receptor, ionotropic, N-methyl D-aspartate 2C |
| H3F3B | H3 histone, family 3B (H3.3B) |
| HBEGF | heparin-binding EGF-like growth factor |
| HEXIM1 | hexamethylene bis-acetamide inducible 1 |
| HIC2 | hypermethylated in cancer 2 |
| HLA-E | major histocompatibility complex, class I, E |
| HPX | hemopexin |
| IER5 | immediate early response 5 |
| JAG1 | jagged 1 |
| JUN | jun proto-oncogene |
| LIF | leukemia inhibitory factor |
| LOC157562 | uncharacterized LOC157562 |
| LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) |
| LTB4R | leukotriene B4 receptor |
| LY6D | lymphocyte antigen 6 complex, locus D |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B |
| MAN2A2 | mannosidase, alpha, class 2A, member 2 |
| MAP3K12 | mitogen-activated protein kinase kinase kinase 12 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase |
| MSX1 | msh homeobox 1 |
| MXD4 | MAX dimerization protein 4 |
| NGDN | neuroguidin, EIF4E binding protein |
| NHLH2 | nescient helix loop helix 2 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 |
| NYNRIN | NYN domain and retroviral integrase containing |
| OVGP1 | oviductal glycoprotein 1, 120kDa |
| PDE4A | phosphodiesterase 4A, cAMP-specific |
| PDGFA | platelet-derived growth factor alpha polypeptide |
| PIDD1 | p53-induced death domain protein 1 |
| PLEKHF1 | pleckstrin homology domain containing, family F (with FYVE domain) member 1 |
| PLK3 | polo-like kinase 3 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 |
| PRDX2 | peroxiredoxin 2 |
| PRICKLE3 | prickle homolog 3 (Drosophila) |
| RALGDS | ral guanine nucleotide dissociation stimulator |
| RER1 | retention in endoplasmic reticulum sorting receptor 1 |
| RGS2 | regulator of G-protein signaling 2 |
| RHBDL1 | rhomboid, veinlet-like 1 (Drosophila) |
| RIN1 | Ras and Rab interactor 1 |
| RNF19B | ring finger protein 19B |
| RNF39 | ring finger protein 39 |
| RPS28 | ribosomal protein S28 |
| RSL1D1 | ribosomal L1 domain containing 1 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 |
| SESN1 | sestrin 1 |
| SFN | stratifin |
| SIX2 | SIX homeobox 2 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 |
| SLC48A1 | solute carrier family 48 (heme transporter), member 1 |
| SLC52A1 | solute carrier family 52 (riboflavin transporter), member 1 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 |
| SNAPC4 | small nuclear RNA activating complex, polypeptide 4, 190kDa |
| SOCS1 | suppressor of cytokine signaling 1 |
| STAG3L1 | stromal antigen 3-like 1 (pseudogene) |
| TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) |
| TREX1 | three prime repair exonuclease 1 |
| TUBB2A | tubulin, beta 2A class IIa |
| UCN | urocortin |
| VAMP5 | vesicle-associated membrane protein 5 |
| ZDHHC11 | zinc finger, DHHC-type containing 11 |
| ZNF34 | zinc finger protein 34 |
| ZNF750 | zinc finger protein 750 |
| Symbol | Name |
|---|---|
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 |
| ADGRA3 | adhesion G protein-coupled receptor A3 |
| ADGRL2 | adhesion G protein-coupled receptor L2 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 |
| AGO2 | argonaute RISC catalytic component 2 |
| ANKS1A | ankyrin repeat and sterile alpha motif domain containing 1A |
| ARHGAP12 | Rho GTPase activating protein 12 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) |
| ARMCX5 | armadillo repeat containing, X-linked 5 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 |
| ATAD2 | ATPase family, AAA domain containing 2 |
| BARD1 | BRCA1 associated RING domain 1 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A |
| BRINP3 | bone morphogenetic protein/retinoic acid inducible neural-specific 3 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B |
| CDK8 | cyclin-dependent kinase 8 |
| CENPE | centromere protein E, 312kDa |
| CHD1 | chromodomain helicase DNA binding protein 1 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 |
| DDX10 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 |
| DENND1B | DENN/MADD domain containing 1B |
| DMXL1 | Dmx-like 1 |
| DSCAM | Down syndrome cell adhesion molecule |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
| ECT2 | epithelial cell transforming 2 |
| EFNA4 | ephrin-A4 |
| EHBP1 | EH domain binding protein 1 |
| ELF1 | E74-like factor 1 (ets domain transcription factor) |
| EPHA4 | EPH receptor A4 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 |
| ERBB2IP | erbb2 interacting protein |
| ESRP1 | epithelial splicing regulatory protein 1 |
| FNBP1L | formin binding protein 1-like |
| FNDC3B | fibronectin type III domain containing 3B |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) |
| GHR | growth hormone receptor |
| GIGYF2 | GRB10 interacting GYF protein 2 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) |
| GRHL2 | grainyhead-like 2 (Drosophila) |
| GSK3B | glycogen synthase kinase 3 beta |
| HJURP | Holliday junction recognition protein |
| HMG20A | high mobility group 20A |
| JARID2 | jumonji, AT rich interactive domain 2 |
| KIF11 | kinesin family member 11 |
| KIF14 | kinesin family member 14 |
| KIF15 | kinesin family member 15 |
| KNTC1 | kinetochore associated 1 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 |
| MCM10 | minichromosome maintenance complex component 10 |
| MDN1 | MDN1, midasin homolog (yeast) |
| MELK | maternal embryonic leucine zipper kinase |
| MGA | MGA, MAX dimerization protein |
| MKL2 | MKL/myocardin-like 2 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 |
| MSH2 | mutS homolog 2 |
| NCAPH | non-SMC condensin I complex, subunit H |
| NDC80 | NDC80 kinetochore complex component |
| NEK4 | NIMA-related kinase 4 |
| NEK7 | NIMA-related kinase 7 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 |
| NIPBL | Nipped-B homolog (Drosophila) |
| NMD3 | NMD3 ribosome export adaptor |
| NRIP1 | nuclear receptor interacting protein 1 |
| NSD1 | nuclear receptor binding SET domain protein 1 |
| PHIP | pleckstrin homology domain interacting protein |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 |
| POLA2 | polymerase (DNA directed), alpha 2, accessory subunit |
| PRR15L | proline rich 15-like |
| PTPN4 | protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) |
| PTPRK | protein tyrosine phosphatase, receptor type, K |
| RAI14 | retinoic acid induced 14 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 |
| RASA1 | RAS p21 protein activator (GTPase activating protein) 1 |
| RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) |
| RBM47 | RNA binding motif protein 47 |
| RCOR1 | REST corepressor 1 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 |
| SAP130 | Sin3A-associated protein, 130kDa |
| SCAF8 | SR-related CTD-associated factor 8 |
| SCYL2 | SCY1-like 2 (S. cerevisiae) |
| SEC24B | SEC24 family member B |
| SFMBT1 | Scm-like with four mbt domains 1 |
| SPC25 | SPC25, NDC80 kinetochore complex component |
| STAG1 | stromal antigen 1 |
| TPX2 | TPX2, microtubule-associated |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) |
| TRPS1 | trichorhinophalangeal syndrome I |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit |
| TTK | TTK protein kinase |
| UVRAG | UV radiation resistance associated |
| VANGL1 | VANGL planar cell polarity protein 1 |
| WDR26 | WD repeat domain 26 |
| WDR70 | WD repeat domain 70 |
| WWP1 | WW domain containing E3 ubiquitin protein ligase 1 |
| ZHX2 | zinc fingers and homeoboxes 2 |
