irregular heartbeat Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Any cardiac rhythm other than the normal sinus rhythm. Such a rhythm may be either of sinus or ectopic origin and either regular or irregular. An arrhythmia may be due to a disturbance in impulse formation or conduction or both. (Human Phenotype Ontology, HP_0011675)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001636
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Genes

47 gene mutations causing the irregular heartbeat phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACADVL acyl-CoA dehydrogenase, very long chain
ACE angiotensin I converting enzyme
AKAP10 A kinase (PRKA) anchor protein 10
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CASQ2 calsequestrin 2 (cardiac muscle)
CDH5 cadherin 5, type 2 (vascular endothelium)
CTNNA3 catenin (cadherin-associated protein), alpha 3
EFNA1 ephrin-A1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXP1 forkhead box P1
GJA1 gap junction protein, alpha 1, 43kDa
GJA5 gap junction protein, alpha 5, 40kDa
GLA galactosidase, alpha
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HAS2 hyaluronan synthase 2
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIRA histone cell cycle regulator
HSPG2 heparan sulfate proteoglycan 2
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
JPH2 junctophilin 2
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNIP2 Kv channel interacting protein 2
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
NHLH1 nescient helix loop helix 1
NRG1 neuregulin 1
NUP155 nucleoporin 155kDa
PITX2 paired-like homeodomain 2
PLN phospholamban
RPSA ribosomal protein SA
RYR2 ryanodine receptor 2 (cardiac)
SCN1A sodium channel, voltage gated, type I alpha subunit
SCN3B sodium channel, voltage gated, type III beta subunit
SCN5A sodium channel, voltage gated, type V alpha subunit
SHOX2 short stature homeobox 2
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SMAD7 SMAD family member 7
SP4 Sp4 transcription factor
TBX3 T-box 3
TBX5 T-box 5
TGM2 transglutaminase 2
TMOD1 tropomodulin 1
VEGFA vascular endothelial growth factor A