irs1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description insulin receptor substrate 1|This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009] (NCBI Entrez Gene Database, 3667)
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Genes

75 genes co-occuring with the biological term irs1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT1S1 AKT1 substrate 1 (proline-rich)
AP1M1 adaptor-related protein complex 1, mu 1 subunit
API5 apoptosis inhibitor 5
APOB apolipoprotein B
AR androgen receptor
ASPH aspartate beta-hydroxylase
BCR breakpoint cluster region
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL6A3 collagen, type VI, alpha 3
CRP C-reactive protein, pentraxin-related
EDN1 endothelin 1
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
GH1 growth hormone 1
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGF2R insulin-like growth factor 2 receptor
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
INS insulin
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KRAS Kirsten rat sarcoma viral oncogene homolog
LYRM1 LYR motif containing 1
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MIR126 microRNA 126
MIR143 microRNA 143
MIR145 microRNA 145
MIR148A microRNA 148a
MIR152 microRNA 152
MIR23A microRNA 23a
MIR96 microRNA 96
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PAX4 paired box 4
PID1 phosphotyrosine interaction domain containing 1
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
PPARG peroxisome proliferator-activated receptor gamma
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKCD protein kinase C, delta
PRKCZ protein kinase C, zeta
PTEN phosphatase and tensin homolog
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD51 RAD51 recombinase
RBP4 retinol binding protein 4, plasma
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPTOR regulatory associated protein of MTOR, complex 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOCS3 suppressor of cytokine signaling 3
SREBF1 sterol regulatory element binding transcription factor 1
TNF tumor necrosis factor
TSC2 tuberous sclerosis 2
VEGFA vascular endothelial growth factor A