isg15 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description ISG15 ubiquitin-like modifier|The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012] (NCBI Entrez Gene Database, 9636)
Similar Terms
Downloads & Tools

Genes

23 genes co-occuring with the biological term isg15 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ATM ATM serine/threonine kinase
CENPW centromere protein W
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
IFNA1 interferon, alpha 1
IFNG interferon, gamma
IFNL3 interferon, lambda 3
ISG15 ISG15 ubiquitin-like modifier
KRAS Kirsten rat sarcoma viral oncogene homolog
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
PCNA proliferating cell nuclear antigen
SULF2 sulfatase 2
TLR3 toll-like receptor 3
TNF tumor necrosis factor
TP63 tumor protein p63
TRIM25 tripartite motif containing 25
UBA7 ubiquitin-like modifier activating enzyme 7
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UBR1 ubiquitin protein ligase E3 component n-recognin 1
USP18 ubiquitin specific peptidase 18
USP21 ubiquitin specific peptidase 21