isocarboxazid-4706 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the isocarboxazid-4706 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACVR1B activin A receptor, type IB
AFF2 AF4/FMR2 family, member 2
AQP3 aquaporin 3 (Gill blood group)
ARTN artemin
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BTG2 BTG family, member 2
CADM4 cell adhesion molecule 4
CASP2 caspase 2, apoptosis-related cysteine peptidase
CAV2 caveolin 2
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCNK cyclin K
CCR7 chemokine (C-C motif) receptor 7
CD47 CD47 molecule
CD83 CD83 molecule
CDC14A cell division cycle 14A
CDK18 cyclin-dependent kinase 18
CDK20 cyclin-dependent kinase 20
CHRNE cholinergic receptor, nicotinic, epsilon (muscle)
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DMXL2 Dmx-like 2
DOC2B double C2-like domains, beta
EFNB3 ephrin-B3
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ERN1 endoplasmic reticulum to nucleus signaling 1
FDPS farnesyl diphosphate synthase
FRMD4A FERM domain containing 4A
GARNL3 GTPase activating Rap/RanGAP domain-like 3
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GOLGA2 golgin A2
HBEGF heparin-binding EGF-like growth factor
HPX hemopexin
INCENP inner centromere protein antigens 135/155kDa
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JPH3 junctophilin 3
KDM5A lysine (K)-specific demethylase 5A
KIAA1654 KIAA1654 protein
LDB1 LIM domain binding 1
LIG4 ligase IV, DNA, ATP-dependent
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LINC00341 long intergenic non-protein coding RNA 341
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LOX lysyl oxidase
LRMP lymphoid-restricted membrane protein
LRP12 low density lipoprotein receptor-related protein 12
LRP2 low density lipoprotein receptor-related protein 2
MAU2 MAU2 sister chromatid cohesion factor
MSX2 msh homeobox 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC5B mucin 5B, oligomeric mucus/gel-forming
NDRG2 NDRG family member 2
NMT1 N-myristoyltransferase 1
NT5M 5',3'-nucleotidase, mitochondrial
NUPR1 nuclear protein, transcriptional regulator, 1
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
ONECUT2 one cut homeobox 2
PAOX polyamine oxidase (exo-N4-amino)
PARD6B par-6 family cell polarity regulator beta
PARP8 poly (ADP-ribose) polymerase family, member 8
PCDHA6 protocadherin alpha 6
PCM1 pericentriolar material 1
PDE4C phosphodiesterase 4C, cAMP-specific
PGR progesterone receptor
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP5C protein phosphatase 5, catalytic subunit
PRAMEF11 PRAME family member 11
PRKD1 protein kinase D1
PTHLH parathyroid hormone-like hormone
RAD52 RAD52 homolog (S. cerevisiae)
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RFXAP regulatory factor X-associated protein
RGS6 regulator of G-protein signaling 6
RHBG Rh family, B glycoprotein (gene/pseudogene)
RIMS2 regulating synaptic membrane exocytosis 2
RPL10 ribosomal protein L10
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SH3BP2 SH3-domain binding protein 2
SIPA1 signal-induced proliferation-associated 1
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC22A14 solute carrier family 22, member 14
SLC26A1 solute carrier family 26 (anion exchanger), member 1
SMAD1 SMAD family member 1
SMAD3 SMAD family member 3
SPON2 spondin 2, extracellular matrix protein
SRD5A3 steroid 5 alpha-reductase 3
SRPR signal recognition particle receptor (docking protein)
SSPN sarcospan
STX7 syntaxin 7
TAAR3 trace amine associated receptor 3 (gene/pseudogene)
THOC5 THO complex 5
WIPF1 WAS/WASL interacting protein family, member 1
ZMYND11 zinc finger, MYND-type containing 11
ZNF112 zinc finger protein 112
ZNF652 zinc finger protein 652

decreased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABHD17B abhydrolase domain containing 17B
ACBD4 acyl-CoA binding domain containing 4
AFF4 AF4/FMR2 family, member 4
AMT aminomethyltransferase
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
BAHCC1 BAH domain and coiled-coil containing 1
BBC3 BCL2 binding component 3
C19ORF40 chromosome 19 open reading frame 40
C2ORF27A chromosome 2 open reading frame 27A
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAMK1 calcium/calmodulin-dependent protein kinase I
CCP110 centriolar coiled coil protein 110kDa
CD3D CD3d molecule, delta (CD3-TCR complex)
CHML choroideremia-like (Rab escort protein 2)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CRYBG3 beta-gamma crystallin domain containing 3
CST6 cystatin E/M
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8
DOCK1 dedicator of cytokinesis 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGFL7 EGF-like-domain, multiple 7
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ELSPBP1 epididymal sperm binding protein 1
ERCC2 excision repair cross-complementation group 2
FAM204A family with sequence similarity 204, member A
FAM46C family with sequence similarity 46, member C
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FRS2 fibroblast growth factor receptor substrate 2
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLRA1 glycine receptor, alpha 1
GRAMD1C GRAM domain containing 1C
HDAC11 histone deacetylase 11
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BO histone cluster 1, H2bo
HOXA4 homeobox A4
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INF2 inverted formin, FH2 and WH2 domain containing
INPP5J inositol polyphosphate-5-phosphatase J
IRAK4 interleukin-1 receptor-associated kinase 4
IRF1 interferon regulatory factor 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITPKC inositol-trisphosphate 3-kinase C
KDM7A lysine (K)-specific demethylase 7A
KIAA0319L KIAA0319-like
KIF13A kinesin family member 13A
KLHL25 kelch-like family member 25
KPTN kaptin (actin binding protein)
KREMEN2 kringle containing transmembrane protein 2
KRT15 keratin 15, type I
KRT31 keratin 31, type I
LOC390998 ribosomal protein L10 pseudogene
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC37A2 leucine rich repeat containing 37, member A2
MYLK myosin light chain kinase
NAG18 NAG18 mRNA
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NPIPB15 nuclear pore complex interacting protein family, member B15
NXPH4 neurexophilin 4
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PDE12 phosphodiesterase 12
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLEKHA6 pleckstrin homology domain containing, family A member 6
POLH polymerase (DNA directed), eta
POLM polymerase (DNA directed), mu
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PTPRS protein tyrosine phosphatase, receptor type, S
RAB3A RAB3A, member RAS oncogene family
RAB3D RAB3D, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIN1 Ras and Rab interactor 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
SAMD9 sterile alpha motif domain containing 9
SCML2 sex comb on midleg-like 2 (Drosophila)
SEC14L2 SEC14-like 2 (S. cerevisiae)
SETD8 SET domain containing (lysine methyltransferase) 8
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SPRR2B small proline-rich protein 2B
STAG3L1 stromal antigen 3-like 1 (pseudogene)
SYNC syncoilin, intermediate filament protein
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
THNSL2 threonine synthase-like 2 (S. cerevisiae)
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR62 WD repeat domain 62
XYLT1 xylosyltransferase I
ZBTB25 zinc finger and BTB domain containing 25
ZNF778 zinc finger protein 778