isoconazole-7211 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the isoconazole-7211 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AK2 adenylate kinase 2
AKAP8L A kinase (PRKA) anchor protein 8-like
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
ARHGAP35 Rho GTPase activating protein 35
ARID1A AT rich interactive domain 1A (SWI-like)
ARL4C ADP-ribosylation factor-like 4C
ARL4D ADP-ribosylation factor-like 4D
ATF3 activating transcription factor 3
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BTBD7 BTB (POZ) domain containing 7
C22ORF46 chromosome 22 open reading frame 46
CADM4 cell adhesion molecule 4
CCKBR cholecystokinin B receptor
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL1A1 collagen, type I, alpha 1
COMP cartilage oligomeric matrix protein
CRY2 cryptochrome circadian clock 2
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8
CYSLTR1 cysteinyl leukotriene receptor 1
DDIT3 DNA-damage-inducible transcript 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNALI1 dynein, axonemal, light intermediate chain 1
DPYS dihydropyrimidinase
DSC3 desmocollin 3
DTX3 deltex 3, E3 ubiquitin ligase
DUSP1 dual specificity phosphatase 1
EDNRB endothelin receptor type B
EGR1 early growth response 1
FAM155A family with sequence similarity 155, member A
FAM46C family with sequence similarity 46, member C
FOS FBJ murine osteosarcoma viral oncogene homolog
FRMD4B FERM domain containing 4B
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD9 frizzled class receptor 9
GEM GTP binding protein overexpressed in skeletal muscle
GZMK granzyme K (granzyme 3; tryptase II)
HBEGF heparin-binding EGF-like growth factor
HFE hemochromatosis
HRH2 histamine receptor H2
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFT122 intraflagellar transport 122
IGHA1 immunoglobulin heavy constant alpha 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITM2C integral membrane protein 2C
JUN jun proto-oncogene
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1A microtubule-associated protein 1A
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MBL2 mannose-binding lectin (protein C) 2, soluble
MPZL1 myelin protein zero-like 1
MTRF1L mitochondrial translational release factor 1-like
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
MZF1 myeloid zinc finger 1
NDN necdin, melanoma antigen (MAGE) family member
NDRG2 NDRG family member 2
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
OSGIN1 oxidative stress induced growth inhibitor 1
PARVB parvin, beta
PCDHGA11 protocadherin gamma subfamily A, 11
PCGF3 polycomb group ring finger 3
PDE11A phosphodiesterase 11A
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNLIPRP2 pancreatic lipase-related protein 2
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RUNX1 runt-related transcription factor 1
SERHL2 serine hydrolase-like 2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SND1-IT1 SND1 intronic transcript 1
SRSF5 serine/arginine-rich splicing factor 5
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TBX6 T-box 6
TEF thyrotrophic embryonic factor
TMEM212 transmembrane protein 212
TMPRSS2 transmembrane protease, serine 2
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIM2 tripartite motif containing 2
U2AF2 U2 small nuclear RNA auxiliary factor 2
VAC14 Vac14 homolog (S. cerevisiae)
WSB1 WD repeat and SOCS box containing 1
ZMAT4 zinc finger, matrin-type 4
ZNF222 zinc finger protein 222
ZNF286A zinc finger protein 286A
ZSCAN2 zinc finger and SCAN domain containing 2

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABHD10 abhydrolase domain containing 10
ACVR1 activin A receptor, type I
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ANXA2P3 annexin A2 pseudogene 3
AR androgen receptor
ARHGAP11A Rho GTPase activating protein 11A
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ASB9 ankyrin repeat and SOCS box containing 9
ATAD5 ATPase family, AAA domain containing 5
BCL9 B-cell CLL/lymphoma 9
BCORL1 BCL6 corepressor-like 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C10ORF88 chromosome 10 open reading frame 88
C1ORF159 chromosome 1 open reading frame 159
C5 complement component 5
CAMTA1 calmodulin binding transcription activator 1
CENPJ centromere protein J
CHMP6 charged multivesicular body protein 6
CTNNBIP1 catenin, beta interacting protein 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAL4 dynein, axonemal, light chain 4
DSN1 DSN1, MIS12 kinetochore complex component
ELOVL4 ELOVL fatty acid elongase 4
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERCC5 excision repair cross-complementation group 5
FBXO31 F-box protein 31
FZD2 frizzled class receptor 2
GLTSCR1 glioma tumor suppressor candidate region gene 1
GMCL1 germ cell-less, spermatogenesis associated 1
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
HEATR3 HEAT repeat containing 3
HIST1H1D histone cluster 1, H1d
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
INF2 inverted formin, FH2 and WH2 domain containing
KRT8P12 keratin 8 pseudogene 12
MBIP MAP3K12 binding inhibitory protein 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MTHFSD methenyltetrahydrofolate synthetase domain containing
NABP2 nucleic acid binding protein 2
NCAM2 neural cell adhesion molecule 2
NECAP2 NECAP endocytosis associated 2
NLK nemo-like kinase
NRBF2 nuclear receptor binding factor 2
NRGN neurogranin (protein kinase C substrate, RC3)
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PARP12 poly (ADP-ribose) polymerase family, member 12
PARP16 poly (ADP-ribose) polymerase family, member 16
PCSK7 proprotein convertase subtilisin/kexin type 7
PDE12 phosphodiesterase 12
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PLD2 phospholipase D2
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLEKHO1 pleckstrin homology domain containing, family O member 1
POLH polymerase (DNA directed), eta
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PTK6 protein tyrosine kinase 6
PTPN9 protein tyrosine phosphatase, non-receptor type 9
R3HCC1L R3H domain and coiled-coil containing 1-like
RBL1 retinoblastoma-like 1
REEP4 receptor accessory protein 4
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RIC8B RIC8 guanine nucleotide exchange factor B
RIPK4 receptor-interacting serine-threonine kinase 4
ROM1 retinal outer segment membrane protein 1
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SAMHD1 SAM domain and HD domain 1
SETD8 SET domain containing (lysine methyltransferase) 8
SGMS1 sphingomyelin synthase 1
SH2B3 SH2B adaptor protein 3
SIK1 salt-inducible kinase 1
SKA1 spindle and kinetochore associated complex subunit 1
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC35A5 solute carrier family 35, member A5
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SOAT1 sterol O-acyltransferase 1
SPANXC SPANX family, member C
SPATA2L spermatogenesis associated 2-like
STXBP1 syntaxin binding protein 1
SYNJ2BP synaptojanin 2 binding protein
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TEP1 telomerase-associated protein 1
TRAIP TRAF interacting protein
TUBGCP5 tubulin, gamma complex associated protein 5
UNKL unkempt family zinc finger-like
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR19 WD repeat domain 19
ZC3H12A zinc finger CCCH-type containing 12A
ZMAT5 zinc finger, matrin-type 5
ZNF205 zinc finger protein 205
ZNF668 zinc finger protein 668
ZNF675 zinc finger protein 675
ZNF813 zinc finger protein 813