isometheptene-5082 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the isometheptene-5082 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
A4GALT alpha 1,4-galactosyltransferase
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4
ACSBG2 acyl-CoA synthetase bubblegum family member 2
AGBL2 ATP/GTP binding protein-like 2
ARHGAP35 Rho GTPase activating protein 35
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATAT1 alpha tubulin acetyltransferase 1
ATF5 activating transcription factor 5
AVPR1A arginine vasopressin receptor 1A
BDKRB1 bradykinin receptor B1
C11ORF16 chromosome 11 open reading frame 16
C1S complement component 1, s subcomponent
C2ORF54 chromosome 2 open reading frame 54
C5ORF42 chromosome 5 open reading frame 42
C9ORF9 chromosome 9 open reading frame 9
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CD3D CD3d molecule, delta (CD3-TCR complex)
CDH10 cadherin 10, type 2 (T2-cadherin)
CEND1 cell cycle exit and neuronal differentiation 1
CNGB3 cyclic nucleotide gated channel beta 3
COBLL1 cordon-bleu WH2 repeat protein-like 1
CPN2 carboxypeptidase N, polypeptide 2
CRHR2 corticotropin releasing hormone receptor 2
CSHL1 chorionic somatomammotropin hormone-like 1
CXCR2 chemokine (C-X-C motif) receptor 2
DAGLA diacylglycerol lipase, alpha
DCTN1 dynactin 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
FAM131B family with sequence similarity 131, member B
FBXO21 F-box protein 21
FOXO4 forkhead box O4
GATA4 GATA binding protein 4
GHRH growth hormone releasing hormone
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPATCH4 G patch domain containing 4
HAMP hepcidin antimicrobial peptide
HEATR6 HEAT repeat containing 6
HEG1 heart development protein with EGF-like domains 1
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HOXA7 homeobox A7
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL4 interleukin 4
ITPK1 inositol-tetrakisphosphate 1-kinase
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KIAA1107 KIAA1107
LDLRAD4 low density lipoprotein receptor class A domain containing 4
MAPT microtubule-associated protein tau
MATN3 matrilin 3
MBD2 methyl-CpG binding domain protein 2
MCF2L MCF.2 cell line derived transforming sequence-like
MCTP2 multiple C2 domains, transmembrane 2
MFAP3 microfibrillar-associated protein 3
MMP9 matrix metallopeptidase 9
MRPL41 mitochondrial ribosomal protein L41
MVD mevalonate (diphospho) decarboxylase
MYO7B myosin VIIB
NF1 neurofibromin 1
NPIPB15 nuclear pore complex interacting protein family, member B15
OR10H1 olfactory receptor, family 10, subfamily H, member 1
PAX2 paired box 2
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PGLYRP4 peptidoglycan recognition protein 4
PID1 phosphotyrosine interaction domain containing 1
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PODNL1 podocan-like 1
PRKCQ protein kinase C, theta
PROX1 prospero homeobox 1
PRPF31 pre-mRNA processing factor 31
PTMS parathymosin
PVR poliovirus receptor
R3HDM1 R3H domain containing 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RFPL1 ret finger protein-like 1
RPL7 ribosomal protein L7
RUNDC3A RUN domain containing 3A
SCN1B sodium channel, voltage gated, type I beta subunit
SKAP1 src kinase associated phosphoprotein 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPAG8 sperm associated antigen 8
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
STOM stomatin
SYNE1 spectrin repeat containing, nuclear envelope 1
TACR1 tachykinin receptor 1
TDRD1 tudor domain containing 1
TMEM40 transmembrane protein 40
TMEM63A transmembrane protein 63A
TREM2 triggering receptor expressed on myeloid cells 2
TRIM49 tripartite motif containing 49
UPK2 uroplakin 2
USF2 upstream transcription factor 2, c-fos interacting
VN1R1 vomeronasal 1 receptor 1
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae)
XAB2 XPA binding protein 2

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
AGMAT agmatine ureohydrolase (agmatinase)
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ANKRD7 ankyrin repeat domain 7
ARID3B AT rich interactive domain 3B (BRIGHT-like)
BAHCC1 BAH domain and coiled-coil containing 1
BTC betacellulin
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
C11ORF63 chromosome 11 open reading frame 63
C14ORF93 chromosome 14 open reading frame 93
C5ORF45 chromosome 5 open reading frame 45
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CAMKMT calmodulin-lysine N-methyltransferase
CCDC85C coiled-coil domain containing 85C
CCRL2 chemokine (C-C motif) receptor-like 2
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDKL3 cyclin-dependent kinase-like 3
CENPO centromere protein O
CIR1 corepressor interacting with RBPJ, 1
CLDN1 claudin 1
CLDN15 claudin 15
CNPY3 canopy FGF signaling regulator 3
CORO2A coronin, actin binding protein, 2A
CXORF56 chromosome X open reading frame 56
DEF6 differentially expressed in FDCP 6 homolog (mouse)
EFNA3 ephrin-A3
EN2 engrailed homeobox 2
ENOX1 ecto-NOX disulfide-thiol exchanger 1
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EXOSC1 exosome component 1
FBXO31 F-box protein 31
FKBP1B FK506 binding protein 1B, 12.6 kDa
FURIN furin (paired basic amino acid cleaving enzyme)
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H2BN histone cluster 1, H2bn
HIST1H2BO histone cluster 1, H2bo
HLX H2.0-like homeobox
IL20RA interleukin 20 receptor, alpha
ISYNA1 inositol-3-phosphate synthase 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0754 KIAA0754
KIAA1462 KIAA1462
LINC00341 long intergenic non-protein coding RNA 341
LRP3 low density lipoprotein receptor-related protein 3
LYPD3 LY6/PLAUR domain containing 3
MANBA mannosidase, beta A, lysosomal
MAP3K7CL MAP3K7 C-terminal like
MAST3 microtubule associated serine/threonine kinase 3
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MUC2 mucin 2, oligomeric mucus/gel-forming
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NDE1 nudE neurodevelopment protein 1
NPM3 nucleophosmin/nucleoplasmin 3
NRTN neurturin
NTSR1 neurotensin receptor 1 (high affinity)
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PALMD palmdelphin
PCOLCE procollagen C-endopeptidase enhancer
PDLIM2 PDZ and LIM domain 2 (mystique)
PDZK1 PDZ domain containing 1
PLAC8 placenta-specific 8
PRPH peripherin
PRR7 proline rich 7 (synaptic)
PRSS53 protease, serine, 53
QSER1 glutamine and serine rich 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RIMBP2 RIMS binding protein 2
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SCARA3 scavenger receptor class A, member 3
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SGK2 serum/glucocorticoid regulated kinase 2
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SND1-IT1 SND1 intronic transcript 1
SPTBN2 spectrin, beta, non-erythrocytic 2
STRA6 stimulated by retinoic acid 6
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBXAS1 thromboxane A synthase 1 (platelet)
TMEM180 transmembrane protein 180
TPST1 tyrosylprotein sulfotransferase 1
TRAF2 TNF receptor-associated factor 2
TUBA3C tubulin, alpha 3c
TUBG2 tubulin, gamma 2
ZBTB48 zinc finger and BTB domain containing 48
ZC2HC1C zinc finger, C2HC-type containing 1C
ZFP30 ZFP30 zinc finger protein
ZNF32 zinc finger protein 32
ZNF391 zinc finger protein 391
ZNF639 zinc finger protein 639
ZNF668 zinc finger protein 668
ZNF778 zinc finger protein 778