isometheptene-6524 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the isometheptene-6524 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
AMPD3 adenosine monophosphate deaminase 3
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BTF3P11 basic transcription factor 3 pseudogene 11
C5ORF42 chromosome 5 open reading frame 42
CA4 carbonic anhydrase IV
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CALD1 caldesmon 1
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CHRM3 cholinergic receptor, muscarinic 3
CHRND cholinergic receptor, nicotinic, delta (muscle)
CIB2 calcium and integrin binding family member 2
CNTNAP1 contactin associated protein 1
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CRISP2 cysteine-rich secretory protein 2
CSPP1 centrosome and spindle pole associated protein 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
DESI2 desumoylating isopeptidase 2
EDA ectodysplasin A
EFNA3 ephrin-A3
ELOVL5 ELOVL fatty acid elongase 5
FGF17 fibroblast growth factor 17
FHL1 four and a half LIM domains 1
GALC galactosylceramidase
GAP43 growth associated protein 43
GAS6 growth arrest-specific 6
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GREM1 gremlin 1, DAN family BMP antagonist
GSTM5 glutathione S-transferase mu 5
HDAC11 histone deacetylase 11
HIPK3 homeodomain interacting protein kinase 3
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IL16 interleukin 16
INCENP inner centromere protein antigens 135/155kDa
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
LAMA4 laminin, alpha 4
LMF2 lipase maturation factor 2
LRRN3 leucine rich repeat neuronal 3
MAP2K5 mitogen-activated protein kinase kinase 5
MAX MYC associated factor X
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MSI1 musashi RNA-binding protein 1
MYH7 myosin, heavy chain 7, cardiac muscle, beta
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NLE1 notchless homolog 1 (Drosophila)
NMBR neuromedin B receptor
NME5 NME/NM23 family member 5
NRIP3 nuclear receptor interacting protein 3
NRN1 neuritin 1
NRP2 neuropilin 2
NT5DC3 5'-nucleotidase domain containing 3
OLFM1 olfactomedin 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PMS2P2 postmeiotic segregation increased 2 pseudogene 2
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRY PTPN13-like, Y-linked
PSD3 pleckstrin and Sec7 domain containing 3
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
PTPRU protein tyrosine phosphatase, receptor type, U
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RBFA ribosome binding factor A (putative)
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPL35A ribosomal protein L35a
SBF1 SET binding factor 1
SEC14L2 SEC14-like 2 (S. cerevisiae)
SIK3 SIK family kinase 3
SLC17A4 solute carrier family 17, member 4
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
STX7 syntaxin 7
TAL1 T-cell acute lymphocytic leukemia 1
TBR1 T-box, brain, 1
TLN1 talin 1
TPMT thiopurine S-methyltransferase
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
WIPF1 WAS/WASL interacting protein family, member 1
WNT7A wingless-type MMTV integration site family, member 7A
WSB1 WD repeat and SOCS box containing 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XYLB xylulokinase homolog (H. influenzae)
ZBTB48 zinc finger and BTB domain containing 48
ZFP36L2 ZFP36 ring finger protein-like 2
ZMYND8 zinc finger, MYND-type containing 8
ZNF277 zinc finger protein 277
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACTG2 actin, gamma 2, smooth muscle, enteric
ADCY7 adenylate cyclase 7
AFAP1 actin filament associated protein 1
APLP1 amyloid beta (A4) precursor-like protein 1
ATAD5 ATPase family, AAA domain containing 5
ATP11B ATPase, class VI, type 11B
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BCORL1 BCL6 corepressor-like 1
C5AR2 complement component 5a receptor 2
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CCDC69 coiled-coil domain containing 69
CD82 CD82 molecule
CDH10 cadherin 10, type 2 (T2-cadherin)
CGA glycoprotein hormones, alpha polypeptide
CLCN5 chloride channel, voltage-sensitive 5
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRELD1 cysteine-rich with EGF-like domains 1
CRLF1 cytokine receptor-like factor 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EAF2 ELL associated factor 2
EDAR ectodysplasin A receptor
FKBP1B FK506 binding protein 1B, 12.6 kDa
FKBPL FK506 binding protein like
FMO4 flavin containing monooxygenase 4
FOXN2 forkhead box N2
FSD1 fibronectin type III and SPRY domain containing 1
GALT galactose-1-phosphate uridylyltransferase
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GPATCH3 G patch domain containing 3
GPR3 G protein-coupled receptor 3
GTF2I general transcription factor IIi
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
IL17RA interleukin 17 receptor A
IL4R interleukin 4 receptor
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KIAA0754 KIAA0754
KLHL25 kelch-like family member 25
KLHL28 kelch-like family member 28
LIME1 Lck interacting transmembrane adaptor 1
LIN7B lin-7 homolog B (C. elegans)
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTBP2 latent transforming growth factor beta binding protein 2
LYPD1 LY6/PLAUR domain containing 1
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCOLN3 mucolipin 3
MECR mitochondrial trans-2-enoyl-CoA reductase
METTL16 methyltransferase like 16
MRPL2 mitochondrial ribosomal protein L2
MT1HL1 metallothionein 1H-like 1
MTA2 metastasis associated 1 family, member 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOL12 nucleolar protein 12
NPIPB15 nuclear pore complex interacting protein family, member B15
NPM3 nucleophosmin/nucleoplasmin 3
NPY5R neuropeptide Y receptor Y5
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDE8B phosphodiesterase 8B
PDGFD platelet derived growth factor D
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PEX26 peroxisomal biogenesis factor 26
PITX2 paired-like homeodomain 2
RGS2 regulator of G-protein signaling 2
RHBG Rh family, B glycoprotein (gene/pseudogene)
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF122 ring finger protein 122
SAMHD1 SAM domain and HD domain 1
SAV1 salvador family WW domain containing protein 1
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
STK16 serine/threonine kinase 16
TCHH trichohyalin
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TMEM120B transmembrane protein 120B
TMEM254 transmembrane protein 254
TPST2 tyrosylprotein sulfotransferase 2
TRAIP TRAF interacting protein
TRIM25 tripartite motif containing 25
TTBK2 tau tubulin kinase 2
VEZT vezatin, adherens junctions transmembrane protein
VPS9D1 VPS9 domain containing 1
ZBTB22 zinc finger and BTB domain containing 22
ZNF350 zinc finger protein 350
ZNF442 zinc finger protein 442
ZNF516 zinc finger protein 516
ZNF750 zinc finger protein 750