isoniazid-2083 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the isoniazid-2083 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ATG2A autophagy related 2A
ATP5SL ATP5S-like
BATF3 basic leucine zipper transcription factor, ATF-like 3
BAX BCL2-associated X protein
C22ORF46 chromosome 22 open reading frame 46
CADPS2 Ca++-dependent secretion activator 2
CCNT1 cyclin T1
CEP162 centrosomal protein 162kDa
CISH cytokine inducible SH2-containing protein
CLIP1 CAP-GLY domain containing linker protein 1
COL7A1 collagen, type VII, alpha 1
COL9A3 collagen, type IX, alpha 3
CPPED1 calcineurin-like phosphoesterase domain containing 1
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
DDO D-aspartate oxidase
DNPEP aspartyl aminopeptidase
DSPP dentin sialophosphoprotein
EFNB1 ephrin-B1
EML2 echinoderm microtubule associated protein like 2
EPHA4 EPH receptor A4
ETV5 ets variant 5
EWSR1 EWS RNA-binding protein 1
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FCMR Fc fragment of IgM receptor
FGFR1 fibroblast growth factor receptor 1
FGFR1OP FGFR1 oncogene partner
FKBP8 FK506 binding protein 8, 38kDa
GIF gastric intrinsic factor (vitamin B synthesis)
GPR3 G protein-coupled receptor 3
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPR4 G protein-coupled receptor 4
GUCY1B3 guanylate cyclase 1, soluble, beta 3
GUSBP3 glucuronidase, beta pseudogene 3
HABP4 hyaluronan binding protein 4
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HIST1H2AJ histone cluster 1, H2aj
HOOK1 hook microtubule-tethering protein 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPG2 heparan sulfate proteoglycan 2
IFI6 interferon, alpha-inducible protein 6
IFT140 intraflagellar transport 140
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP1 insulin-like growth factor binding protein 1
IGFBP5 insulin-like growth factor binding protein 5
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCTD14 potassium channel tetramerization domain containing 14
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KIAA1644 KIAA1644
KIF1C kinesin family member 1C
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LPAR3 lysophosphatidic acid receptor 3
LRP1 low density lipoprotein receptor-related protein 1
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MBNL2 muscleblind-like splicing regulator 2
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MCTP1 multiple C2 domains, transmembrane 1
MUC2 mucin 2, oligomeric mucus/gel-forming
MYRF myelin regulatory factor
NCAPH2 non-SMC condensin II complex, subunit H2
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NGLY1 N-glycanase 1
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
PAM peptidylglycine alpha-amidating monooxygenase
PAOX polyamine oxidase (exo-N4-amino)
PCDH12 protocadherin 12
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PLXNB1 plexin B1
PRR4 proline rich 4 (lacrimal)
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RAD51B RAD51 paralog B
RGS12 regulator of G-protein signaling 12
S1PR1 sphingosine-1-phosphate receptor 1
SCAMP1 secretory carrier membrane protein 1
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLK STE20-like kinase
SNAP23 synaptosomal-associated protein, 23kDa
SNW1 SNW domain containing 1
SOAT1 sterol O-acyltransferase 1
SOS2 son of sevenless homolog 2 (Drosophila)
SPATS2L spermatogenesis associated, serine-rich 2-like
TJP3 tight junction protein 3
TLN2 talin 2
TM2D1 TM2 domain containing 1
TMEM63A transmembrane protein 63A
TMEM70 transmembrane protein 70
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM23 tripartite motif containing 23
TSPAN2 tetraspanin 2
TTC30A tetratricopeptide repeat domain 30A
TTLL5 tubulin tyrosine ligase-like family member 5
YPEL1 yippee-like 1 (Drosophila)
ZNF189 zinc finger protein 189

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ADCY6 adenylate cyclase 6
AMT aminomethyltransferase
ANAPC2 anaphase promoting complex subunit 2
ARHGAP10 Rho GTPase activating protein 10
ARID4A AT rich interactive domain 4A (RBP1-like)
ARRB2 arrestin, beta 2
BAG4 BCL2-associated athanogene 4
BIK BCL2-interacting killer (apoptosis-inducing)
BOLA1 bolA family member 1
C17ORF70 chromosome 17 open reading frame 70
C1QTNF1 C1q and tumor necrosis factor related protein 1
C7ORF69 chromosome 7 open reading frame 69
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CCDC176 coiled-coil domain containing 176
CD151 CD151 molecule (Raph blood group)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CENPQ centromere protein Q
CEP131 centrosomal protein 131kDa
CHML choroideremia-like (Rab escort protein 2)
CLDN15 claudin 15
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
EPPK1 epiplakin 1
F8 coagulation factor VIII, procoagulant component
FANCC Fanconi anemia, complementation group C
FBP1 fructose-1,6-bisphosphatase 1
FBXW12 F-box and WD repeat domain containing 12
FGD1 FYVE, RhoGEF and PH domain containing 1
FKBPL FK506 binding protein like
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
HDAC5 histone deacetylase 5
HIST1H2BJ histone cluster 1, H2bj
HLA-J major histocompatibility complex, class I, J (pseudogene)
HOXB13 homeobox B13
HYAL2 hyaluronoglucosaminidase 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IL4R interleukin 4 receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIG4 ligase IV, DNA, ATP-dependent
LONRF3 LON peptidase N-terminal domain and ring finger 3
MAGEF1 melanoma antigen family F1
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MED9 mediator complex subunit 9
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae)
MNX1 motor neuron and pancreas homeobox 1
MON1B MON1 secretory trafficking family member B
MOSPD3 motile sperm domain containing 3
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MYO9A myosin IXA
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NINJ1 ninjurin 1
NPR3 natriuretic peptide receptor 3
NT5M 5',3'-nucleotidase, mitochondrial
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PARD6A par-6 family cell polarity regulator alpha
PCSK7 proprotein convertase subtilisin/kexin type 7
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1
PHGDH phosphoglycerate dehydrogenase
PILRB paired immunoglobin-like type 2 receptor beta
PLA2G15 phospholipase A2, group XV
PLEKHA6 pleckstrin homology domain containing, family A member 6
POLE polymerase (DNA directed), epsilon, catalytic subunit
POMT2 protein-O-mannosyltransferase 2
PPP6R2 protein phosphatase 6, regulatory subunit 2
PRAME preferentially expressed antigen in melanoma
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PTPN9 protein tyrosine phosphatase, non-receptor type 9
QTRT1 queuine tRNA-ribosyltransferase 1
RASA2 RAS p21 protein activator 2
RBL1 retinoblastoma-like 1
RBM42 RNA binding motif protein 42
RPAP1 RNA polymerase II associated protein 1
SAP30BP SAP30 binding protein
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SCRN3 secernin 3
SEC14L2 SEC14-like 2 (S. cerevisiae)
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPAG7 sperm associated antigen 7
SPEG SPEG complex locus
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TKFC triokinase/FMN cyclase
TM7SF2 transmembrane 7 superfamily member 2
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR18 WD repeat domain 18
WDR76 WD repeat domain 76
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF16 zinc finger protein 16
ZNF276 zinc finger protein 276
ZNF665 zinc finger protein 665