isoniazid-7197 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the isoniazid-7197 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ALOX12 arachidonate 12-lipoxygenase
ANKRD12 ankyrin repeat domain 12
APLP2 amyloid beta (A4) precursor-like protein 2
AQP3 aquaporin 3 (Gill blood group)
B9D1 B9 protein domain 1
BMP2K BMP2 inducible kinase
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
C10ORF88 chromosome 10 open reading frame 88
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCPG1 cell cycle progression 1
CD44 CD44 molecule (Indian blood group)
CEP290 centrosomal protein 290kDa
CLASP2 cytoplasmic linker associated protein 2
CLCN5 chloride channel, voltage-sensitive 5
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTNS cystinosin, lysosomal cystine transporter
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29
DICER1 dicer 1, ribonuclease type III
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DSCAM Down syndrome cell adhesion molecule
DXO decapping exoribonuclease
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EGFR epidermal growth factor receptor
EIF5B eukaryotic translation initiation factor 5B
ERAP1 endoplasmic reticulum aminopeptidase 1
ESR1 estrogen receptor 1
FBLN1 fibulin 1
FDX1 ferredoxin 1
GSTCD glutathione S-transferase, C-terminal domain containing
HDGFRP3 hepatoma-derived growth factor, related protein 3
HIST1H2BC histone cluster 1, H2bc
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
INTS6 integrator complex subunit 6
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIF25-AS1 KIF25 antisense RNA 1
L2HGDH L-2-hydroxyglutarate dehydrogenase
LIG4 ligase IV, DNA, ATP-dependent
LIN7A lin-7 homolog A (C. elegans)
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MARS methionyl-tRNA synthetase
MBNL2 muscleblind-like splicing regulator 2
MBNL3 muscleblind-like splicing regulator 3
MED14 mediator complex subunit 14
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
NCKAP1 NCK-associated protein 1
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
OSGIN2 oxidative stress induced growth inhibitor family member 2
PCDH9 protocadherin 9
PDCD2 programmed cell death 2
PGK1 phosphoglycerate kinase 1
PMCH pro-melanin-concentrating hormone
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
POM121L2 POM121 transmembrane nucleoporin-like 2
PRDX2 peroxiredoxin 2
PRKCE protein kinase C, epsilon
PROSC proline synthetase co-transcribed homolog (bacterial)
PRRC2C proline-rich coiled-coil 2C
PSPH phosphoserine phosphatase
QKI QKI, KH domain containing, RNA binding
RAB2A RAB2A, member RAS oncogene family
RCAN1 regulator of calcineurin 1
RFTN1 raftlin, lipid raft linker 1
RGS2 regulator of G-protein signaling 2
RHOQ ras homolog family member Q
RPAIN RPA interacting protein
RPLP2 ribosomal protein, large, P2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC39A9 solute carrier family 39, member 9
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SP100 SP100 nuclear antigen
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STARD5 StAR-related lipid transfer (START) domain containing 5
STBD1 starch binding domain 1
STK4 serine/threonine kinase 4
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TFG TRK-fused gene
TMOD1 tropomodulin 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TREX1 three prime repair exonuclease 1
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
TXN thioredoxin
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
VDAC3 voltage-dependent anion channel 3
WLS wntless Wnt ligand secretion mediator
ZNF273 zinc finger protein 273
ZNF573 zinc finger protein 573
ZNF675 zinc finger protein 675

decreased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABHD17B abhydrolase domain containing 17B
ADGRE5 adhesion G protein-coupled receptor E5
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALPK1 alpha-kinase 1
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARSB arylsulfatase B
ASB9 ankyrin repeat and SOCS box containing 9
ASPHD1 aspartate beta-hydroxylase domain containing 1
BCAS1 breast carcinoma amplified sequence 1
BTBD2 BTB (POZ) domain containing 2
C1ORF159 chromosome 1 open reading frame 159
CCDC9 coiled-coil domain containing 9
CDADC1 cytidine and dCMP deaminase domain containing 1
CFAP69 cilia and flagella associated protein 69
CHKB choline kinase beta
CIC capicua transcriptional repressor
CLDN15 claudin 15
CLSPN claspin
CNGB3 cyclic nucleotide gated channel beta 3
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNM1 dynamin 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EIF5A2 eukaryotic translation initiation factor 5A2
FKBP10 FK506 binding protein 10, 65 kDa
FPGS folylpolyglutamate synthase
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GNL1 guanine nucleotide binding protein-like 1
GSTA4 glutathione S-transferase alpha 4
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HIST1H2BO histone cluster 1, H2bo
ICK intestinal cell (MAK-like) kinase
IGFBP6 insulin-like growth factor binding protein 6
IL15RA interleukin 15 receptor, alpha
IL4R interleukin 4 receptor
JMJD4 jumonji domain containing 4
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KIAA0319L KIAA0319-like
KRI1 KRI1 homolog (S. cerevisiae)
KRT31 keratin 31, type I
LHX1 LIM homeobox 1
LOC390998 ribosomal protein L10 pseudogene
MAP1S microtubule-associated protein 1S
MBTD1 mbt domain containing 1
MITF microphthalmia-associated transcription factor
MMP9 matrix metallopeptidase 9
MTCL1 microtubule crosslinking factor 1
NDRG1 N-myc downstream regulated 1
NFS1 NFS1 cysteine desulfurase
PADI1 peptidyl arginine deiminase, type I
PAIP2B poly(A) binding protein interacting protein 2B
PAQR6 progestin and adipoQ receptor family member VI
PARP16 poly (ADP-ribose) polymerase family, member 16
PCDHB3 protocadherin beta 3
PDE12 phosphodiesterase 12
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PICK1 protein interacting with PRKCA 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G3 phospholipase A2, group III
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
QTRT1 queuine tRNA-ribosyltransferase 1
RAD54L2 RAD54-like 2 (S. cerevisiae)
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF126P1 ring finger protein 126 pseudogene 1
RNF170 ring finger protein 170
SBNO2 strawberry notch homolog 2 (Drosophila)
SDC3 syndecan 3
SIRT6 sirtuin 6
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SOX12 SRY (sex determining region Y)-box 12
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
THBS3 thrombospondin 3
THRAP3 thyroid hormone receptor associated protein 3
TICAM1 toll-like receptor adaptor molecule 1
TLR5 toll-like receptor 5
TRAF2 TNF receptor-associated factor 2
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTC30A tetratricopeptide repeat domain 30A
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
TWSG1 twisted gastrulation BMP signaling modulator 1
VGF VGF nerve growth factor inducible
VPS9D1 VPS9 domain containing 1
WNT1 wingless-type MMTV integration site family, member 1
XAB2 XPA binding protein 2
YEATS2 YEATS domain containing 2
ZBED8 zinc finger, BED-type containing 8
ZBTB48 zinc finger and BTB domain containing 48
ZFP69B ZFP69 zinc finger protein B
ZNF212 zinc finger protein 212
ZNF254 zinc finger protein 254