isotretinoin-2407 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the isotretinoin-2407 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADD3 adducin 3 (gamma)
AQP9 aquaporin 9
ARHGAP12 Rho GTPase activating protein 12
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
C1ORF106 chromosome 1 open reading frame 106
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCR1 chemokine (C-C motif) receptor 1
CCSER2 coiled-coil serine-rich protein 2
CD1D CD1d molecule
CD300A CD300a molecule
CD300C CD300c molecule
CD38 CD38 molecule
CDHR2 cadherin-related family member 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL7A1 collagen, type VII, alpha 1
CREM cAMP responsive element modulator
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
ENDOD1 endonuclease domain containing 1
EPAS1 endothelial PAS domain protein 1
EXPH5 exophilin 5
FAM134B family with sequence similarity 134, member B
FGR FGR proto-oncogene, Src family tyrosine kinase
FLOT1 flotillin 1
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GAS7 growth arrest-specific 7
GCLM glutamate-cysteine ligase, modifier subunit
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2
HAB1 B1 for mucin
HBEGF heparin-binding EGF-like growth factor
HMOX1 heme oxygenase 1
HOXA1 homeobox A1
HOXA5 homeobox A5
HPD 4-hydroxyphenylpyruvate dioxygenase
HPSE heparanase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IL10RA interleukin 10 receptor, alpha
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KANK1 KN motif and ankyrin repeat domains 1
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LIMD2 LIM domain containing 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL7A methyltransferase like 7A
MMP25 matrix metallopeptidase 25
MYBPH myosin binding protein H
NCF1C neutrophil cytosolic factor 1C pseudogene
NF2 neurofibromin 2 (merlin)
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
PALLD palladin, cytoskeletal associated protein
PDLIM5 PDZ and LIM domain 5
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLSCR1 phospholipid scramblase 1
POPDC2 popeye domain containing 2
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRDM1 PR domain containing 1, with ZNF domain
PRY PTPN13-like, Y-linked
PTGES prostaglandin E synthase
RGS1 regulator of G-protein signaling 1
RHOBTB3 Rho-related BTB domain containing 3
RIT1 Ras-like without CAAX 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SGSH N-sulfoglucosamine sulfohydrolase
SLA Src-like-adaptor
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC35F6 solute carrier family 35, member F6
SLC48A1 solute carrier family 48 (heme transporter), member 1
SMAD3 SMAD family member 3
SMOX spermine oxidase
STX11 syntaxin 11
STX1A syntaxin 1A (brain)
TBL2 transducin (beta)-like 2
TCEA2 transcription elongation factor A (SII), 2
TGM2 transglutaminase 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TREM1 triggering receptor expressed on myeloid cells 1
TRIM23 tripartite motif containing 23
TSC22D4 TSC22 domain family, member 4
UPB1 ureidopropionase, beta
ZNF185 zinc finger protein 185 (LIM domain)
ZNF93 zinc finger protein 93

decreased expression

Symbol Name
ADGRA3 adhesion G protein-coupled receptor A3
AEN apoptosis enhancing nuclease
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
AMT aminomethyltransferase
ANXA3 annexin A3
BAHCC1 BAH domain and coiled-coil containing 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
C10ORF2 chromosome 10 open reading frame 2
CA2 carbonic anhydrase II
CA5BP1 carbonic anhydrase VB pseudogene 1
CCDC86 coiled-coil domain containing 86
CCS copper chaperone for superoxide dismutase
CDR2L cerebellar degeneration-related protein 2-like
CECR1 cat eye syndrome chromosome region, candidate 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLEC5A C-type lectin domain family 5, member A
CPNE7 copine VII
CX3CR1 chemokine (C-X3-C motif) receptor 1
DCTPP1 dCTP pyrophosphatase 1
DDN dendrin
DEPTOR DEP domain containing MTOR-interacting protein
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
FAM163A family with sequence similarity 163, member A
FAM86B1 family with sequence similarity 86, member B1
FEM1C fem-1 homolog c (C. elegans)
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GSTZ1 glutathione S-transferase zeta 1
HOPX HOP homeobox
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
ISOC2 isochorismatase domain containing 2
JMJD4 jumonji domain containing 4
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KLF11 Kruppel-like factor 11
LAMP5 lysosomal-associated membrane protein family, member 5
LAX1 lymphocyte transmembrane adaptor 1
LPPR3 lipid phosphate phosphatase-related protein type 3
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRRK1 leucine-rich repeat kinase 1
MAN1C1 mannosidase, alpha, class 1C, member 1
METTL21B methyltransferase like 21B
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTA2 metastasis associated 1 family, member 2
MYBBP1A MYB binding protein (P160) 1a
NCS1 neuronal calcium sensor 1
NIPAL2 NIPA-like domain containing 2
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLCB4 phospholipase C, beta 4
POLM polymerase (DNA directed), mu
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPP6R1 protein phosphatase 6, regulatory subunit 1
PRR4 proline rich 4 (lacrimal)
PTGES2 prostaglandin E synthase 2
PUS7 pseudouridylate synthase 7 (putative)
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
PYCRL pyrroline-5-carboxylate reductase-like
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RABL3 RAB, member of RAS oncogene family-like 3
RARS arginyl-tRNA synthetase
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)
RFTN1 raftlin, lipid raft linker 1
RNH1 ribonuclease/angiogenin inhibitor 1
RRP1 ribosomal RNA processing 1
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SH2D4A SH2 domain containing 4A
SIAH2 siah E3 ubiquitin protein ligase 2
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC35F2 solute carrier family 35, member F2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMYD5 SMYD family member 5
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SOX12 SRY (sex determining region Y)-box 12
TDRD7 tudor domain containing 7
TERT telomerase reverse transcriptase
TET3 tet methylcytosine dioxygenase 3
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TLR2 toll-like receptor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOMM34 translocase of outer mitochondrial membrane 34
TRIM66 tripartite motif containing 66
TRPV2 transient receptor potential cation channel, subfamily V, member 2
TTLL12 tubulin tyrosine ligase-like family member 12
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UNG uracil-DNA glycosylase
VNN2 vanin 2
WASF3 WAS protein family, member 3
XAF1 XIAP associated factor 1
ZNF747 zinc finger protein 747