isoxicam-1698 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the isoxicam-1698 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ALDOB aldolase B, fructose-bisphosphate
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APOC1 apolipoprotein C-I
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ASAP1-IT1 ASAP1 intronic transcript 1
ATP11A ATPase, class VI, type 11A
ATP7A ATPase, Cu++ transporting, alpha polypeptide
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
BAG4 BCL2-associated athanogene 4
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BRCA2 breast cancer 2, early onset
BTBD7 BTB (POZ) domain containing 7
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASP1 caspase 1, apoptosis-related cysteine peptidase
CEP350 centrosomal protein 350kDa
CGREF1 cell growth regulator with EF-hand domain 1
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CNOT4 CCR4-NOT transcription complex, subunit 4
CTTN cortactin
DGAT1 diacylglycerol O-acyltransferase 1
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
E2F4 E2F transcription factor 4, p107/p130-binding
EDNRB endothelin receptor type B
ETAA1 Ewing tumor-associated antigen 1
FAM174B family with sequence similarity 174, member B
FHL1 four and a half LIM domains 1
FKBP10 FK506 binding protein 10, 65 kDa
GK glycerol kinase
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR107 G protein-coupled receptor 107
GPR137 G protein-coupled receptor 137
GPRASP1 G protein-coupled receptor associated sorting protein 1
GSDMB gasdermin B
HK2 hexokinase 2
HSPA4 heat shock 70kDa protein 4
IFT74 intraflagellar transport 74
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
LIN7B lin-7 homolog B (C. elegans)
LINC00094 long intergenic non-protein coding RNA 94
LMNB1 lamin B1
MAPK8 mitogen-activated protein kinase 8
MAST2 microtubule associated serine/threonine kinase 2
MCM3AP minichromosome maintenance complex component 3 associated protein
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED25 mediator complex subunit 25
METTL16 methyltransferase like 16
MFAP3 microfibrillar-associated protein 3
MTA2 metastasis associated 1 family, member 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NCALD neurocalcin delta
NCAPH2 non-SMC condensin II complex, subunit H2
NCS1 neuronal calcium sensor 1
NEK1 NIMA-related kinase 1
NMT1 N-myristoyltransferase 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PARD6B par-6 family cell polarity regulator beta
PCNX pecanex homolog (Drosophila)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PML promyelocytic leukemia
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRB1 proline-rich protein BstNI subfamily 1
PTGES prostaglandin E synthase
PVT1 Pvt1 oncogene (non-protein coding)
QPCTL glutaminyl-peptide cyclotransferase-like
RAB28 RAB28, member RAS oncogene family
RAD51B RAD51 paralog B
RAD52 RAD52 homolog (S. cerevisiae)
RBBP9 retinoblastoma binding protein 9
RER1 retention in endoplasmic reticulum sorting receptor 1
RNF126P1 ring finger protein 126 pseudogene 1
RNF43 ring finger protein 43
S100A8 S100 calcium binding protein A8
SCAMP1 secretory carrier membrane protein 1
SCAPER S-phase cyclin A-associated protein in the ER
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SKI SKI proto-oncogene
SLC35E2 solute carrier family 35, member E2
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SPINK5 serine peptidase inhibitor, Kazal type 5
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPON1 spondin 1, extracellular matrix protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STK17B serine/threonine kinase 17b
STX1A syntaxin 1A (brain)
STX7 syntaxin 7
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TK2 thymidine kinase 2, mitochondrial
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TSC22D4 TSC22 domain family, member 4
TTLL5 tubulin tyrosine ligase-like family member 5
UST uronyl-2-sulfotransferase
ZFPL1 zinc finger protein-like 1
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF227 zinc finger protein 227
ZNF350 zinc finger protein 350

decreased expression

Symbol Name
ADAT1 adenosine deaminase, tRNA-specific 1
AKIRIN1 akirin 1
ALDOC aldolase C, fructose-bisphosphate
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ALPK1 alpha-kinase 1
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ANXA2P3 annexin A2 pseudogene 3
ASB8 ankyrin repeat and SOCS box containing 8
BBC3 BCL2 binding component 3
BRD9 bromodomain containing 9
C11ORF68 chromosome 11 open reading frame 68
C14ORF132 chromosome 14 open reading frame 132
C4ORF29 chromosome 4 open reading frame 29
C7ORF43 chromosome 7 open reading frame 43
CCDC85C coiled-coil domain containing 85C
CDC42BPB CDC42 binding protein kinase beta (DMPK-like)
CEP97 centrosomal protein 97kDa
CIC capicua transcriptional repressor
CLCN5 chloride channel, voltage-sensitive 5
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CRYBG3 beta-gamma crystallin domain containing 3
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DCAF10 DDB1 and CUL4 associated factor 10
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DNAL4 dynein, axonemal, light chain 4
DVL1 dishevelled segment polarity protein 1
EHD3 EH-domain containing 3
EPPK1 epiplakin 1
ERCC4 excision repair cross-complementation group 4
ERF Ets2 repressor factor
FBRS fibrosin
FBXW12 F-box and WD repeat domain containing 12
FER fer (fps/fes related) tyrosine kinase
FLCN folliculin
FLRT3 fibronectin leucine rich transmembrane protein 3
FSTL3 follistatin-like 3 (secreted glycoprotein)
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLS2 glutaminase 2 (liver, mitochondrial)
GMIP GEM interacting protein
GRAMD4 GRAM domain containing 4
GSTA4 glutathione S-transferase alpha 4
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUSBP3 glucuronidase, beta pseudogene 3
HOXC11 homeobox C11
KIF3B kinesin family member 3B
KLHL12 kelch-like family member 12
KPNA4 karyopherin alpha 4 (importin alpha 3)
LAMB3 laminin, beta 3
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LYRM9 LYR motif containing 9
MAN2C1 mannosidase, alpha, class 2C, member 1
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MBTD1 mbt domain containing 1
MFAP2 microfibrillar-associated protein 2
MITF microphthalmia-associated transcription factor
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MYO1D myosin ID
NRSN2 neurensin 2
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PCSK7 proprotein convertase subtilisin/kexin type 7
PHACTR4 phosphatase and actin regulator 4
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLA2G10 phospholipase A2, group X
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PTPRU protein tyrosine phosphatase, receptor type, U
QSOX1 quiescin Q6 sulfhydryl oxidase 1
QTRT1 queuine tRNA-ribosyltransferase 1
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RFWD3 ring finger and WD repeat domain 3
RIBC2 RIB43A domain with coiled-coils 2
RNF31 ring finger protein 31
RPAP2 RNA polymerase II associated protein 2
SCAMP4 secretory carrier membrane protein 4
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SIDT1 SID1 transmembrane family, member 1
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SNHG20 small nucleolar RNA host gene 20
SPINK4 serine peptidase inhibitor, Kazal type 4
STAG3L1 stromal antigen 3-like 1 (pseudogene)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TNS2 tensin 2
TRIM16 tripartite motif containing 16
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
VASH1 vasohibin 1
WDR91 WD repeat domain 91
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XYLT2 xylosyltransferase II
ZFP69B ZFP69 zinc finger protein B
ZNF394 zinc finger protein 394
ZNF408 zinc finger protein 408
ZNF510 zinc finger protein 510
ZNF611 zinc finger protein 611
ZNF652 zinc finger protein 652
ZNF778 zinc finger protein 778