isoxsuprine-1485 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the isoxsuprine-1485 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM8 ADAM metallopeptidase domain 8
ADGRE5 adhesion G protein-coupled receptor E5
ANKRD6 ankyrin repeat domain 6
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARTN artemin
ATF7IP activating transcription factor 7 interacting protein
BCAS1 breast carcinoma amplified sequence 1
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BCO1 beta-carotene oxygenase 1
BMP2K BMP2 inducible kinase
C17ORF53 chromosome 17 open reading frame 53
C1ORF56 chromosome 1 open reading frame 56
CACYBP calcyclin binding protein
CALML5 calmodulin-like 5
CCDC186 coiled-coil domain containing 186
CCDC93 coiled-coil domain containing 93
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFLAR CASP8 and FADD-like apoptosis regulator
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTNS cystinosin, lysosomal cystine transporter
CXORF21 chromosome X open reading frame 21
CYHR1 cysteine/histidine-rich 1
CYLD cylindromatosis (turban tumor syndrome)
DAPK3 death-associated protein kinase 3
DCAKD dephospho-CoA kinase domain containing
DMTN dematin actin binding protein
EDNRA endothelin receptor type A
EFR3B EFR3 homolog B (S. cerevisiae)
ENGASE endo-beta-N-acetylglucosaminidase
F3 coagulation factor III (thromboplastin, tissue factor)
FANCA Fanconi anemia, complementation group A
FILIP1L filamin A interacting protein 1-like
FLJ10038 uncharacterized protein FLJ10038
FOXG1 forkhead box G1
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GOSR2 golgi SNAP receptor complex member 2
GPR137 G protein-coupled receptor 137
IL16 interleukin 16
IL1RAPL1 interleukin 1 receptor accessory protein-like 1
IQCE IQ motif containing E
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIAA0754 KIAA0754
KRT17 keratin 17, type I
LHB luteinizing hormone beta polypeptide
LMAN1 lectin, mannose-binding, 1
LRRC14 leucine rich repeat containing 14
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAPK14 mitogen-activated protein kinase 14
MID1 midline 1
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MRPL41 mitochondrial ribosomal protein L41
MT1F metallothionein 1F
MTA2 metastasis associated 1 family, member 2
NPIPB3 nuclear pore complex interacting protein family, member B3
ORAI2 ORAI calcium release-activated calcium modulator 2
OSBPL2 oxysterol binding protein-like 2
PADI1 peptidyl arginine deiminase, type I
PARP16 poly (ADP-ribose) polymerase family, member 16
PDE10A phosphodiesterase 10A
PDGFB platelet-derived growth factor beta polypeptide
PHC1 polyhomeotic homolog 1 (Drosophila)
PLCD1 phospholipase C, delta 1
PLIN2 perilipin 2
PTDSS2 phosphatidylserine synthase 2
PURA purine-rich element binding protein A
RPL13P5 ribosomal protein L13 pseudogene 5
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
RTEL1 regulator of telomere elongation helicase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC12A8 solute carrier family 12, member 8
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SRI sorcin
STEAP4 STEAP family member 4
STRN striatin, calmodulin binding protein
TFPI2 tissue factor pathway inhibitor 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM63A transmembrane protein 63A
TMPRSS6 transmembrane protease, serine 6
TREX1 three prime repair exonuclease 1
TTC28 tetratricopeptide repeat domain 28
UPP1 uridine phosphorylase 1
VASP vasodilator-stimulated phosphoprotein
VEGFA vascular endothelial growth factor A
WIZ widely interspaced zinc finger motifs
WWTR1 WW domain containing transcription regulator 1
ZCCHC4 zinc finger, CCHC domain containing 4
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF10 zinc finger protein 10
ZNF250 zinc finger protein 250
ZNF516 zinc finger protein 516

decreased expression

Symbol Name
ABHD14A abhydrolase domain containing 14A
ACAD10 acyl-CoA dehydrogenase family, member 10
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AGO3 argonaute RISC catalytic component 3
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
APOD apolipoprotein D
ARMC6 armadillo repeat containing 6
ARRB1 arrestin, beta 1
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATF7IP2 activating transcription factor 7 interacting protein 2
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BRAF B-Raf proto-oncogene, serine/threonine kinase
C19ORF73 chromosome 19 open reading frame 73
C7ORF43 chromosome 7 open reading frame 43
CA11 carbonic anhydrase XI
CLCN5 chloride channel, voltage-sensitive 5
CLDN15 claudin 15
CRABP1 cellular retinoic acid binding protein 1
CTC1 CTS telomere maintenance complex component 1
CTSK cathepsin K
DSCAM Down syndrome cell adhesion molecule
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EPHA2 EPH receptor A2
ERN1 endoplasmic reticulum to nucleus signaling 1
FBXW12 F-box and WD repeat domain containing 12
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FLRT3 fibronectin leucine rich transmembrane protein 3
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPATCH2L G patch domain containing 2-like
GRTP1 growth hormone regulated TBC protein 1
HHLA3 HERV-H LTR-associating 3
IDI2-AS1 IDI2 antisense RNA 1
IL17RA interleukin 17 receptor A
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KIAA0894 KIAA0894 protein
LINC00115 long intergenic non-protein coding RNA 115
LRP2 low density lipoprotein receptor-related protein 2
LRRC61 leucine rich repeat containing 61
MCOLN3 mucolipin 3
MED15 mediator complex subunit 15
MED9 mediator complex subunit 9
METTL16 methyltransferase like 16
MITF microphthalmia-associated transcription factor
MSRA methionine sulfoxide reductase A
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NDE1 nudE neurodevelopment protein 1
NKX3-2 NK3 homeobox 2
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
PACS1 phosphofurin acidic cluster sorting protein 1
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PODXL2 podocalyxin-like 2
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PRKCE protein kinase C, epsilon
PRPH peripherin
PYCRL pyrroline-5-carboxylate reductase-like
QTRT1 queuine tRNA-ribosyltransferase 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF126P1 ring finger protein 126 pseudogene 1
RNF167 ring finger protein 167
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
SCAMP4 secretory carrier membrane protein 4
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SHARPIN SHANK-associated RH domain interactor
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC22A14 solute carrier family 22, member 14
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SP1 Sp1 transcription factor
SPRYD7 SPRY domain containing 7
STARD3 StAR-related lipid transfer (START) domain containing 3
STARD5 StAR-related lipid transfer (START) domain containing 5
TMEM104 transmembrane protein 104
TRABD TraB domain containing
TRIM5 tripartite motif containing 5
TTC30A tetratricopeptide repeat domain 30A
UBQLN4 ubiquilin 4
USP19 ubiquitin specific peptidase 19
VEGFB vascular endothelial growth factor B
VIPR1 vasoactive intestinal peptide receptor 1
VPS9D1 VPS9 domain containing 1
WDR25 WD repeat domain 25
WFDC2 WAP four-disulfide core domain 2
ZBED1 zinc finger, BED-type containing 1
ZBTB22 zinc finger and BTB domain containing 22
ZNF280D zinc finger protein 280D
ZNF350 zinc finger protein 350
ZNF423 zinc finger protein 423
ZNF428 zinc finger protein 428
ZNF442 zinc finger protein 442
ZNF770 zinc finger protein 770