isoxsuprine-1904 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the isoxsuprine-1904 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
AKAP13 A kinase (PRKA) anchor protein 13
ARHGAP32 Rho GTPase activating protein 32
AVPI1 arginine vasopressin-induced 1
AXIN1 axin 1
BCAS4 breast carcinoma amplified sequence 4
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2L14 BCL2-like 14 (apoptosis facilitator)
BDNF brain-derived neurotrophic factor
BMP2 bone morphogenetic protein 2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDHR2 cadherin-related family member 2
CHN2 chimerin 2
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric)
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CLU clusterin
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNOT6 CCR4-NOT transcription complex, subunit 6
CPNE7 copine VII
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSPP1 centrosome and spindle pole associated protein 1
CTH cystathionine gamma-lyase
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DUSP1 dual specificity phosphatase 1
EGLN2 egl-9 family hypoxia-inducible factor 2
ELMO2 engulfment and cell motility 2
ETV1 ets variant 1
ETV7 ets variant 7
FBN1 fibrillin 1
FBXO41 F-box protein 41
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GLS glutaminase
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GRAMD1B GRAM domain containing 1B
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IGL immunoglobulin lambda locus
IL11 interleukin 11
IL1R2 interleukin 1 receptor, type II
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KHK ketohexokinase (fructokinase)
LMO4 LIM domain only 4
LOC647070 uncharacterized LOC647070
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
LY86 lymphocyte antigen 86
MADD MAP-kinase activating death domain
MAP7 microtubule-associated protein 7
MICALL1 MICAL-like 1
MPPE1 metallophosphoesterase 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MYL10 myosin, light chain 10, regulatory
MYL9 myosin, light chain 9, regulatory
MYO15B myosin XVB
MYO9A myosin IXA
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit
NSUN5P1 NOP2/Sun domain family, member 5 pseudogene 1
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
NUP214 nucleoporin 214kDa
NUP98 nucleoporin 98kDa
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene)
OSBPL10 oxysterol binding protein-like 10
PC pyruvate carboxylase
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PIGR polymeric immunoglobulin receptor
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLA2G10 phospholipase A2, group X
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRDM11 PR domain containing 11
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RHOQ ras homolog family member Q
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila)
RPL23 ribosomal protein L23
RUNX1 runt-related transcription factor 1
RUNX3 runt-related transcription factor 3
SBNO1 strawberry notch homolog 1 (Drosophila)
SH2D1A SH2 domain containing 1A
SKAP1 src kinase associated phosphoprotein 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SMAD5 SMAD family member 5
SOD2 superoxide dismutase 2, mitochondrial
SPN sialophorin
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like
SZRD1 SUZ RNA binding domain containing 1
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TBCD tubulin folding cofactor D
TCL1A T-cell leukemia/lymphoma 1A
TK2 thymidine kinase 2, mitochondrial
VEGFA vascular endothelial growth factor A
XAB2 XPA binding protein 2
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF280A zinc finger protein 280A
ZNF701 zinc finger protein 701
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ADRB2 adrenoceptor beta 2, surface
AMOTL2 angiomotin like 2
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ARGLU1 arginine and glutamate rich 1
ARHGAP5 Rho GTPase activating protein 5
ATAT1 alpha tubulin acetyltransferase 1
BAG3 BCL2-associated athanogene 3
BCL7A B-cell CLL/lymphoma 7A
C19ORF24 chromosome 19 open reading frame 24
C1ORF109 chromosome 1 open reading frame 109
C8ORF60 chromosome 8 open reading frame 60
CCNA1 cyclin A1
CCP110 centriolar coiled coil protein 110kDa
CDC45 cell division cycle 45
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEP85 centrosomal protein 85kDa
CEP97 centrosomal protein 97kDa
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CHEK2 checkpoint kinase 2
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CISH cytokine inducible SH2-containing protein
CMTR1 cap methyltransferase 1
COASY CoA synthase
CSRNP2 cysteine-serine-rich nuclear protein 2
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DCTN4 dynactin 4 (p62)
DDIT4 DNA-damage-inducible transcript 4
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
EXOC2 exocyst complex component 2
GALNS galactosamine (N-acetyl)-6-sulfatase
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GALR3 galanin receptor 3
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GOLGA8B golgin A8 family, member B
GSTZ1 glutathione S-transferase zeta 1
HAS2 hyaluronan synthase 2
HIST1H2BC histone cluster 1, H2bc
HSPB8 heat shock 22kDa protein 8
JMJD4 jumonji domain containing 4
KIAA0753 KIAA0753
KLF7 Kruppel-like factor 7 (ubiquitous)
KLHL26 kelch-like family member 26
KRT34 keratin 34, type I
LACTB2 lactamase, beta 2
LHFP lipoma HMGIC fusion partner
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAMLD1 mastermind-like domain containing 1
MAPK3 mitogen-activated protein kinase 3
MDN1 MDN1, midasin homolog (yeast)
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MTMR6 myotubularin related protein 6
NDE1 nudE neurodevelopment protein 1
NDFIP1 Nedd4 family interacting protein 1
NFE2L3 nuclear factor, erythroid 2-like 3
NINJ1 ninjurin 1
NMU neuromedin U
ORC2 origin recognition complex, subunit 2
OSTM1 osteopetrosis associated transmembrane protein 1
OXR1 oxidation resistance 1
PAQR4 progestin and adipoQ receptor family member IV
PCOLCE2 procollagen C-endopeptidase enhancer 2
PEX12 peroxisomal biogenesis factor 12
PEX13 peroxisomal biogenesis factor 13
PIKFYVE phosphoinositide kinase, FYVE finger containing
PLAU plasminogen activator, urokinase
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
POU2F1 POU class 2 homeobox 1
PYGB phosphorylase, glycogen; brain
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RECQL4 RecQ protein-like 4
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RIPPLY3 ripply transcriptional repressor 3
RPA2 replication protein A2, 32kDa
RPS10P5 ribosomal protein S10 pseudogene 5
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SFMBT1 Scm-like with four mbt domains 1
SH3GL1 SH3-domain GRB2-like 1
SHPK sedoheptulokinase
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRBD1 S1 RNA binding domain 1
STK16 serine/threonine kinase 16
TCEAL1 transcription elongation factor A (SII)-like 1
TOP2B topoisomerase (DNA) II beta 180kDa
TTLL12 tubulin tyrosine ligase-like family member 12
TWSG1 twisted gastrulation BMP signaling modulator 1
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
USP32 ubiquitin specific peptidase 32
WASF3 WAS protein family, member 3
XK X-linked Kx blood group
ZCCHC8 zinc finger, CCHC domain containing 8
ZDHHC18 zinc finger, DHHC-type containing 18