isoxsuprine-1985 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the isoxsuprine-1985 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ARHGAP10 Rho GTPase activating protein 10
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL3 B-cell CLL/lymphoma 3
BRCA2 breast cancer 2, early onset
C5ORF45 chromosome 5 open reading frame 45
CA9 carbonic anhydrase IX
CAV3 caveolin 3
CCHCR1 coiled-coil alpha-helical rod protein 1
CDHR2 cadherin-related family member 2
CEL carboxyl ester lipase
CEP152 centrosomal protein 152kDa
CHD3 chromodomain helicase DNA binding protein 3
CYLD cylindromatosis (turban tumor syndrome)
DHRS3 dehydrogenase/reductase (SDR family) member 3
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DNASE1L1 deoxyribonuclease I-like 1
DNM1 dynamin 1
DUSP10 dual specificity phosphatase 10
EFS embryonal Fyn-associated substrate
EPHB4 EPH receptor B4
FBXO31 F-box protein 31
FBXO42 F-box protein 42
FCMR Fc fragment of IgM receptor
FMNL1 formin-like 1
FTH1 ferritin, heavy polypeptide 1
FTO fat mass and obesity associated
FURIN furin (paired basic amino acid cleaving enzyme)
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPATCH4 G patch domain containing 4
GRIK5 glutamate receptor, ionotropic, kainate 5
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
GTPBP1 GTP binding protein 1
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1
HRH3 histamine receptor H3
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
IGSF6 immunoglobulin superfamily, member 6
IL2RB interleukin 2 receptor, beta
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
ITSN1 intersectin 1 (SH3 domain protein)
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA0485 uncharacterized LOC57235
LENEP lens epithelial protein
LMNA lamin A/C
LY6E lymphocyte antigen 6 complex, locus E
MAP2K5 mitogen-activated protein kinase kinase 5
MGAM maltase-glucoamylase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
MYL10 myosin, light chain 10, regulatory
MYO9B myosin IXB
NAT9 N-acetyltransferase 9 (GCN5-related, putative)
NCOR2 nuclear receptor corepressor 2
NIPAL2 NIPA-like domain containing 2
NRBP1 nuclear receptor binding protein 1
NRGN neurogranin (protein kinase C substrate, RC3)
NT5M 5',3'-nucleotidase, mitochondrial
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
OBSL1 obscurin-like 1
ORAI2 ORAI calcium release-activated calcium modulator 2
OVGP1 oviductal glycoprotein 1, 120kDa
PARP16 poly (ADP-ribose) polymerase family, member 16
PBX2 pre-B-cell leukemia homeobox 2
PDE4A phosphodiesterase 4A, cAMP-specific
PHF11 PHD finger protein 11
PHF21A PHD finger protein 21A
PIDD1 p53-induced death domain protein 1
PLA2G5 phospholipase A2, group V
PLEC plectin
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4
PTGES prostaglandin E synthase
RERE arginine-glutamic acid dipeptide (RE) repeats
RHBDD3 rhomboid domain containing 3
RORC RAR-related orphan receptor C
RPS11 ribosomal protein S11
SAFB2 scaffold attachment factor B2
SIK3 SIK family kinase 3
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SPN sialophorin
TDRD3 tudor domain containing 3
TMEM206 transmembrane protein 206
TPRA1 transmembrane protein, adipocyte asscociated 1
WAS Wiskott-Aldrich syndrome
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF197 zinc finger protein 197
ZNF248 zinc finger protein 248
ZNF408 zinc finger protein 408

decreased expression

Symbol Name
ABT1 activator of basal transcription 1
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
AIDA axin interactor, dorsalization associated
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
ANKHD1 ankyrin repeat and KH domain containing 1
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2
ARMT1 acidic residue methyltransferase 1
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
ASUN asunder spermatogenesis regulator
BAG2 BCL2-associated athanogene 2
BATF basic leucine zipper transcription factor, ATF-like
C21ORF59 chromosome 21 open reading frame 59
CCNL2 cyclin L2
CDC45 cell division cycle 45
CDC73 cell division cycle 73
CENPQ centromere protein Q
CEP85 centrosomal protein 85kDa
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLDND1 claudin domain containing 1
COMMD10 COMM domain containing 10
COMMD8 COMM domain containing 8
DCPS decapping enzyme, scavenger
DDA1 DET1 and DDB1 associated 1
DEF8 differentially expressed in FDCP 8 homolog (mouse)
DLD dihydrolipoamide dehydrogenase
DUSP12 dual specificity phosphatase 12
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
ENOPH1 enolase-phosphatase 1
EXOSC9 exosome component 9
FAF1 Fas (TNFRSF6) associated factor 1
FASTKD5 FAST kinase domains 5
FBXL4 F-box and leucine-rich repeat protein 4
FIP1L1 factor interacting with PAPOLA and CPSF1
GAR1 GAR1 ribonucleoprotein
GDE1 glycerophosphodiester phosphodiesterase 1
GMCL1 germ cell-less, spermatogenesis associated 1
GPN3 GPN-loop GTPase 3
GPS1 G protein pathway suppressor 1
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa
HACD2 3-hydroxyacyl-CoA dehydratase 2
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HNRNPF heterogeneous nuclear ribonucleoprotein F
HRSP12 heat-responsive protein 12
IMPACT impact RWD domain protein
ITFG1 integrin alpha FG-GAP repeat containing 1
KRI1 KRI1 homolog (S. cerevisiae)
LAMP5 lysosomal-associated membrane protein family, member 5
LYRM2 LYR motif containing 2
MAPKBP1 mitogen-activated protein kinase binding protein 1
MATK megakaryocyte-associated tyrosine kinase
MBTPS1 membrane-bound transcription factor peptidase, site 1
MIS12 MIS12 kinetochore complex component
MRPS7 mitochondrial ribosomal protein S7
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative)
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NMD3 NMD3 ribosome export adaptor
NTHL1 nth endonuclease III-like 1 (E. coli)
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PAGR1 PAXIP1 associated glutamate-rich protein 1
PAQR3 progestin and adipoQ receptor family member III
PARG poly (ADP-ribose) glycohydrolase
PEMT phosphatidylethanolamine N-methyltransferase
PEPD peptidase D
PHKG2 phosphorylase kinase, gamma 2 (testis)
PNRC1 proline-rich nuclear receptor coactivator 1
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
PRMT5 protein arginine methyltransferase 5
PSAT1 phosphoserine aminotransferase 1
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
RAP1A RAP1A, member of RAS oncogene family
RPP14 ribonuclease P/MRP 14kDa subunit
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RSL24D1 ribosomal L24 domain containing 1
SDHAF3 succinate dehydrogenase complex assembly factor 3
SIAH2 siah E3 ubiquitin protein ligase 2
SLC35B1 solute carrier family 35, member B1
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1
STRA13 stimulated by retinoic acid 13
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TMEM183A transmembrane protein 183A
TMEM230 transmembrane protein 230
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TRPM2 transient receptor potential cation channel, subfamily M, member 2
UBA5 ubiquitin-like modifier activating enzyme 5
UBAC1 UBA domain containing 1
UBFD1 ubiquitin family domain containing 1
UTP11L UTP11-like, U3 small nucleolar ribonucleoprotein (yeast)
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
VDAC1 voltage-dependent anion channel 1
WDR46 WD repeat domain 46
XBP1 X-box binding protein 1
YIPF5 Yip1 domain family, member 5
ZDHHC13 zinc finger, DHHC-type containing 13
ZFAND1 zinc finger, AN1-type domain 1
ZNHIT1 zinc finger, HIT-type containing 1