isoxsuprine-4205 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the isoxsuprine-4205 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACVR1B activin A receptor, type IB
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
APC adenomatous polyposis coli
AQP3 aquaporin 3 (Gill blood group)
ARL14 ADP-ribosylation factor-like 14
ARR3 arrestin 3, retinal (X-arrestin)
ATG10 autophagy related 10
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
BBC3 BCL2 binding component 3
BCL2A1 BCL2-related protein A1
C14ORF79 chromosome 14 open reading frame 79
C17ORF53 chromosome 17 open reading frame 53
C17ORF59 chromosome 17 open reading frame 59
C17ORF70 chromosome 17 open reading frame 70
C21ORF2 chromosome 21 open reading frame 2
C9ORF156 chromosome 9 open reading frame 156
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEMIP cell migration inducing protein, hyaluronan binding
CLCN7 chloride channel, voltage-sensitive 7
CTH cystathionine gamma-lyase
DHRS9 dehydrogenase/reductase (SDR family) member 9
DIO2 deiodinase, iodothyronine, type II
DMBT1 deleted in malignant brain tumors 1
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DUSP1 dual specificity phosphatase 1
EPB41L1 erythrocyte membrane protein band 4.1-like 1
ERC2 ELKS/RAB6-interacting/CAST family member 2
FRMD4A FERM domain containing 4A
GGT1 gamma-glutamyltransferase 1
GJA8 gap junction protein, alpha 8, 50kDa
GK2 glycerol kinase 2
GK3P glycerol kinase 3 pseudogene
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBB hemoglobin, beta
HIPK3 homeodomain interacting protein kinase 3
HIST1H4C histone cluster 1, H4c
IGFBP7 insulin-like growth factor binding protein 7
IL11 interleukin 11
IL33 interleukin 33
IL33R interleukin 33 receptor
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LARGE like-glycosyltransferase
LRP1 low density lipoprotein receptor-related protein 1
MAP7 microtubule-associated protein 7
MAPK11 mitogen-activated protein kinase 11
MEF2D myocyte enhancer factor 2D
MMP3 matrix metallopeptidase 3
MT1F metallothionein 1F
MT1M metallothionein 1M
MX1 MX dynamin-like GTPase 1
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NEURL1 neuralized E3 ubiquitin protein ligase 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NOV nephroblastoma overexpressed
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PITX1 paired-like homeodomain 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PPEF1 protein phosphatase, EF-hand calcium binding domain 1
PQLC2 PQ loop repeat containing 2
PTGES prostaglandin E synthase
PTHLH parathyroid hormone-like hormone
PTPRU protein tyrosine phosphatase, receptor type, U
QPCTL glutaminyl-peptide cyclotransferase-like
RB1 retinoblastoma 1
RPS3A ribosomal protein S3A
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SMOX spermine oxidase
SPTBN1 spectrin, beta, non-erythrocytic 1
STC1 stanniocalcin 1
SULF1 sulfatase 1
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SYT12 synaptotagmin XII
TAPBPL TAP binding protein-like
TBC1D2B TBC1 domain family, member 2B
TGFB2 transforming growth factor, beta 2
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TRPA1 transient receptor potential cation channel, subfamily A, member 1
WSB1 WD repeat and SOCS box containing 1
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF268 zinc finger protein 268
ZNF639 zinc finger protein 639
ZNF695 zinc finger protein 695
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACE angiotensin I converting enzyme
ADAM2 ADAM metallopeptidase domain 2
ANXA2P1 annexin A2 pseudogene 1
ARHGAP22 Rho GTPase activating protein 22
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARRB2 arrestin, beta 2
BIRC3 baculoviral IAP repeat containing 3
C11ORF80 chromosome 11 open reading frame 80
C14ORF105 chromosome 14 open reading frame 105
C7ORF69 chromosome 7 open reading frame 69
CAMKMT calmodulin-lysine N-methyltransferase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CBX8 chromobox homolog 8
CCDC25 coiled-coil domain containing 25
CD70 CD70 molecule
CEMP1 cementum protein 1
CHPF chondroitin polymerizing factor
CLDN1 claudin 1
CLEC16A C-type lectin domain family 16, member A
CLTCL1 clathrin, heavy chain-like 1
CNN1 calponin 1, basic, smooth muscle
CRYGC crystallin, gamma C
CTSF cathepsin F
DNAL4 dynein, axonemal, light chain 4
DSPP dentin sialophosphoprotein
EBF2 early B-cell factor 2
ERAP2 endoplasmic reticulum aminopeptidase 2
ERCC2 excision repair cross-complementation group 2
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM102A family with sequence similarity 102, member A
FGF23 fibroblast growth factor 23
FRMPD1 FERM and PDZ domain containing 1
GBX2 gastrulation brain homeobox 2
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GRM4 glutamate receptor, metabotropic 4
GSTA3 glutathione S-transferase alpha 3
H2AFJ H2A histone family, member J
HIST1H2BN histone cluster 1, H2bn
HIST1H3G histone cluster 1, H3g
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXA6 homeobox A6
ICOS inducible T-cell co-stimulator
IFT140 intraflagellar transport 140
IL15RA interleukin 15 receptor, alpha
IRF2BP1 interferon regulatory factor 2 binding protein 1
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KIAA1456 KIAA1456
KLF13 Kruppel-like factor 13
KRT20 keratin 20, type I
LIME1 Lck interacting transmembrane adaptor 1
LPAR4 lysophosphatidic acid receptor 4
LTC4S leukotriene C4 synthase
LY6D lymphocyte antigen 6 complex, locus D
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MDFI MyoD family inhibitor
MGP matrix Gla protein
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTCP1 mature T-cell proliferation 1
MXD3 MAX dimerization protein 3
MYH15 myosin, heavy chain 15
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLD3 phospholipase D family, member 3
PROX1 prospero homeobox 1
PRR7 proline rich 7 (synaptic)
PRSS53 protease, serine, 53
RAB11B RAB11B, member RAS oncogene family
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RAPSN receptor-associated protein of the synapse
RNF126P1 ring finger protein 126 pseudogene 1
RNF39 ring finger protein 39
RPL23AP32 ribosomal protein L23a pseudogene 32
RUNDC3B RUN domain containing 3B
S1PR1 sphingosine-1-phosphate receptor 1
SBNO2 strawberry notch homolog 2 (Drosophila)
SERGEF secretion regulating guanine nucleotide exchange factor
SLC46A3 solute carrier family 46, member 3
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SLN sarcolipin
SNRPN small nuclear ribonucleoprotein polypeptide N
SOX21 SRY (sex determining region Y)-box 21
SPATA1 spermatogenesis associated 1
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SSBP3 single stranded DNA binding protein 3
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TESPA1 thymocyte expressed, positive selection associated 1
TLN1 talin 1
TLR2 toll-like receptor 2
TMPRSS4 transmembrane protease, serine 4
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TRIM21 tripartite motif containing 21
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TTLL1 tubulin tyrosine ligase-like family member 1
XAB2 XPA binding protein 2
ZNF324 zinc finger protein 324