isradipine-6347 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the isradipine-6347 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADRBK2 adrenergic, beta, receptor kinase 2
AKR1C4 aldo-keto reductase family 1, member C4
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALG12 ALG12, alpha-1,6-mannosyltransferase
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
B9D2 B9 protein domain 2
BAIAP3 BAI1-associated protein 3
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BIN1 bridging integrator 1
BTBD7 BTB (POZ) domain containing 7
C9ORF156 chromosome 9 open reading frame 156
CDH7 cadherin 7, type 2
CDRT1 CMT1A duplicated region transcript 1
CFLAR CASP8 and FADD-like apoptosis regulator
CRYBB2P1 crystallin, beta B2 pseudogene 1
DESI2 desumoylating isopeptidase 2
DOCK5 dedicator of cytokinesis 5
EGR1 early growth response 1
ERC2-IT1 ERC2 intronic transcript 1
FGF1 fibroblast growth factor 1 (acidic)
FGF5 fibroblast growth factor 5
FOXF2 forkhead box F2
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GABARAPL1 GABA(A) receptor-associated protein like 1
GAL3ST4 galactose-3-O-sulfotransferase 4
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
HAMP hepcidin antimicrobial peptide
HIRA histone cell cycle regulator
HMOX1 heme oxygenase 1
HOXB5 homeobox B5
IFFO1 intermediate filament family orphan 1
IFI6 interferon, alpha-inducible protein 6
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KDM4C lysine (K)-specific demethylase 4C
KLHDC3 kelch domain containing 3
LAMC2 laminin, gamma 2
LIG3 ligase III, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
LOC257152 uncharacterized LOC257152
MAN1A1 mannosidase, alpha, class 1A, member 1
MCL1 myeloid cell leukemia 1
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MLANA melan-A
MTA1 metastasis associated 1
N4BP1 NEDD4 binding protein 1
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NEU3 sialidase 3 (membrane sialidase)
NOL10 nucleolar protein 10
NPFFR1 neuropeptide FF receptor 1
OVGP1 oviductal glycoprotein 1, 120kDa
PDCD2 programmed cell death 2
PDGFB platelet-derived growth factor beta polypeptide
PDLIM7 PDZ and LIM domain 7 (enigma)
PDS5A PDS5 cohesin associated factor A
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHO1 pleckstrin homology domain containing, family O member 1
POU6F1 POU class 6 homeobox 1
PPP4R4 protein phosphatase 4, regulatory subunit 4
PQBP1 polyglutamine binding protein 1
PQLC2 PQ loop repeat containing 2
PRB1 proline-rich protein BstNI subfamily 1
PRDX2 peroxiredoxin 2
PTGES2 prostaglandin E synthase 2
PTK6 protein tyrosine kinase 6
PTPRU protein tyrosine phosphatase, receptor type, U
R3HCC1L R3H domain and coiled-coil containing 1-like
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RIN3 Ras and Rab interactor 3
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
S100A13 S100 calcium binding protein A13
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
SMAD7 SMAD family member 7
SRD5A3 steroid 5 alpha-reductase 3
STBD1 starch binding domain 1
STK4 serine/threonine kinase 4
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAPBP TAP binding protein (tapasin)
TBL1Y transducin (beta)-like 1, Y-linked
TGFA transforming growth factor, alpha
THBD thrombomodulin
TNS1 tensin 1
TRD T cell receptor delta locus
TSPAN2 tetraspanin 2
TTLL3 tubulin tyrosine ligase-like family member 3
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UHRF1BP1L UHRF1 binding protein 1-like
UNC119 unc-119 homolog (C. elegans)
ZMYM2 zinc finger, MYM-type 2
ZNF224 zinc finger protein 224
ZNF286A zinc finger protein 286A
ZNF287 zinc finger protein 287
ZNF492 zinc finger protein 492

decreased expression

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ARHGAP32 Rho GTPase activating protein 32
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C10ORF88 chromosome 10 open reading frame 88
C5 complement component 5
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDR2L cerebellar degeneration-related protein 2-like
CEP131 centrosomal protein 131kDa
CTC1 CTS telomere maintenance complex component 1
DCLRE1A DNA cross-link repair 1A
DDIT3 DNA-damage-inducible transcript 3
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16
DUSP8 dual specificity phosphatase 8
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ELP3 elongator acetyltransferase complex subunit 3
ELP6 elongator acetyltransferase complex subunit 6
ERI3 ERI1 exoribonuclease family member 3
ETNK2 ethanolamine kinase 2
EVPL envoplakin
FADS2 fatty acid desaturase 2
FAM53B family with sequence similarity 53, member B
FAM86C1 family with sequence similarity 86, member C1
FANCC Fanconi anemia, complementation group C
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GPR39 G protein-coupled receptor 39
GRAMD4 GRAM domain containing 4
GYS1 glycogen synthase 1 (muscle)
HIST1H3G histone cluster 1, H3g
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXA4 homeobox A4
HSPA2 heat shock 70kDa protein 2
IFT54 intraflagellar transport 54
IGFLR1 IGF-like family receptor 1
IL17RA interleukin 17 receptor A
IL4R interleukin 4 receptor
IREB2 iron-responsive element binding protein 2
ISYNA1 inositol-3-phosphate synthase 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KDM4D lysine (K)-specific demethylase 4D
KDM5C lysine (K)-specific demethylase 5C
KIAA0556 KIAA0556
KLF7 Kruppel-like factor 7 (ubiquitous)
LONRF3 LON peptidase N-terminal domain and ring finger 3
LPAR6 lysophosphatidic acid receptor 6
LPPR4 lipid phosphate phosphatase-related protein type 4
LRP3 low density lipoprotein receptor-related protein 3
LRRK1 leucine-rich repeat kinase 1
LY6G5C lymphocyte antigen 6 complex, locus G5C
LZTR1 leucine-zipper-like transcription regulator 1
MAGEH1 melanoma antigen family H1
MOXD1 monooxygenase, DBH-like 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL41 mitochondrial ribosomal protein L41
MTG1 mitochondrial ribosome-associated GTPase 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYBBP1A MYB binding protein (P160) 1a
NR1H2 nuclear receptor subfamily 1, group H, member 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDLIM2 PDZ and LIM domain 2 (mystique)
PHF11 PHD finger protein 11
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PMF1 polyamine-modulated factor 1
POMT2 protein-O-mannosyltransferase 2
PPAN peter pan homolog (Drosophila)
PRR14L proline rich 14-like
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RGS17 regulator of G-protein signaling 17
RIBC2 RIB43A domain with coiled-coils 2
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SHPK sedoheptulokinase
SLC12A9 solute carrier family 12, member 9
SREBF1 sterol regulatory element binding transcription factor 1
STARD13 StAR-related lipid transfer (START) domain containing 13
STX1A syntaxin 1A (brain)
TAGLN3 transgelin 3
TMEM121 transmembrane protein 121
TMEM39B transmembrane protein 39B
TMEM8B transmembrane protein 8B
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TOR4A torsin family 4, member A
TSPAN1 tetraspanin 1
TSPAN8 tetraspanin 8
TSPYL2 TSPY-like 2
WDR76 WD repeat domain 76
ZBTB44 zinc finger and BTB domain containing 44
ZC3H12A zinc finger CCCH-type containing 12A
ZC3H3 zinc finger CCCH-type containing 3
ZNF574 zinc finger protein 574
ZNF606 zinc finger protein 606