isradipine-6508 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the isradipine-6508 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
AK2 adenylate kinase 2
ANKFY1 ankyrin repeat and FYVE domain containing 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL2BP ADP-ribosylation factor-like 2 binding protein
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BEGAIN brain-enriched guanylate kinase-associated
BHLHE40 basic helix-loop-helix family, member e40
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BTF3P11 basic transcription factor 3 pseudogene 11
C19ORF66 chromosome 19 open reading frame 66
C1ORF159 chromosome 1 open reading frame 159
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CDK14 cyclin-dependent kinase 14
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CLGN calmegin
COL19A1 collagen, type XIX, alpha 1
CSPP1 centrosome and spindle pole associated protein 1
CUZD1 CUB and zona pellucida-like domains 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYLD cylindromatosis (turban tumor syndrome)
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8
DLG5 discs, large homolog 5 (Drosophila)
DOK4 docking protein 4
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ETAA1 Ewing tumor-associated antigen 1
ETV5 ets variant 5
FBLN1 fibulin 1
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FGF13 fibroblast growth factor 13
FNTB farnesyltransferase, CAAX box, beta
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GBP2 guanylate binding protein 2, interferon-inducible
GFI1 growth factor independent 1 transcription repressor
GJB3 gap junction protein, beta 3, 31kDa
HCRP1 hepatocellular carcinoma-related HCRP1
HIC2 hypermethylated in cancer 2
HOXC5 homeobox C5
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IHH indian hedgehog
IL1RN interleukin 1 receptor antagonist
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KIF25 kinesin family member 25
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KRT24 keratin 24, type I
KRT85 keratin 85, type II
LMAN1 lectin, mannose-binding, 1
LMF2 lipase maturation factor 2
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAK male germ cell-associated kinase
MALL mal, T-cell differentiation protein-like
MARK4 MAP/microtubule affinity-regulating kinase 4
MBD1 methyl-CpG binding domain protein 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MR1 major histocompatibility complex, class I-related
MTA1 metastasis associated 1
NPR1 natriuretic peptide receptor 1
NR2E3 nuclear receptor subfamily 2, group E, member 3
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PCDH1 protocadherin 1
PCDH8 protocadherin 8
PLLP plasmolipin
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRAMEF11 PRAME family member 11
PRDM14 PR domain containing 14
PRELP proline/arginine-rich end leucine-rich repeat protein
RBM12B RNA binding motif protein 12B
REM1 RAS (RAD and GEM)-like GTP-binding 1
RGS4 regulator of G-protein signaling 4
RPL35A ribosomal protein L35a
RTEL1 regulator of telomere elongation helicase 1
RUNDC3A RUN domain containing 3A
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SIRT4 sirtuin 4
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORBS1 sorbin and SH3 domain containing 1
SPAG16 sperm associated antigen 16
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
STAC SH3 and cysteine rich domain
TADA3 transcriptional adaptor 3
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TCP11L1 t-complex 11, testis-specific-like 1
TLR2 toll-like receptor 2
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TSPAN1 tetraspanin 1
TUBA3C tubulin, alpha 3c
TXNL4A thioredoxin-like 4A
USP46 ubiquitin specific peptidase 46
UTRN utrophin
VPS13B vacuolar protein sorting 13 homolog B (yeast)
XDH xanthine dehydrogenase
ZFPL1 zinc finger protein-like 1
ZNF235 zinc finger protein 235

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAP2 ArfGAP with dual PH domains 2
ADTRP androgen-dependent TFPI-regulating protein
AKTIP AKT interacting protein
ARHGAP10 Rho GTPase activating protein 10
ARHGAP24 Rho GTPase activating protein 24
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ATG7 autophagy related 7
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAHCC1 BAH domain and coiled-coil containing 1
BFSP1 beaded filament structural protein 1, filensin
BIK BCL2-interacting killer (apoptosis-inducing)
C11ORF30 chromosome 11 open reading frame 30
C11ORF68 chromosome 11 open reading frame 68
C17ORF80 chromosome 17 open reading frame 80
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCDC9 coiled-coil domain containing 9
CDH10 cadherin 10, type 2 (T2-cadherin)
CORT cortistatin
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CXXC4 CXXC finger protein 4
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
FBRS fibrosin
FBXO31 F-box protein 31
FGF23 fibroblast growth factor 23
FLCN folliculin
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLS2 glutaminase 2 (liver, mitochondrial)
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPATCH3 G patch domain containing 3
GPX2 glutathione peroxidase 2
GRTP1 growth hormone regulated TBC protein 1
HAMP hepcidin antimicrobial peptide
HIST1H3B histone cluster 1, H3b
HIST1H4F histone cluster 1, H4f
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HPS6 Hermansky-Pudlak syndrome 6
HSPB6 heat shock protein, alpha-crystallin-related, B6
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA1456 KIAA1456
KLHL25 kelch-like family member 25
KREMEN2 kringle containing transmembrane protein 2
LHX1 LIM homeobox 1
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LRP3 low density lipoprotein receptor-related protein 3
LRRC20 leucine rich repeat containing 20
LTBP2 latent transforming growth factor beta binding protein 2
LYRM9 LYR motif containing 9
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAN2C1 mannosidase, alpha, class 2C, member 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTA2 metastasis associated 1 family, member 2
MTSS1L metastasis suppressor 1-like
MUC3B mucin 3B, cell surface associated
MXD3 MAX dimerization protein 3
NNAT neuronatin
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDE8B phosphodiesterase 8B
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PGBD5 piggyBac transposable element derived 5
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRAMEF10 PRAME family member 10
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RLF rearranged L-myc fusion
RNF126P1 ring finger protein 126 pseudogene 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SETD1A SET domain containing 1A
SGCE sarcoglycan, epsilon
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
TAOK1 TAO kinase 1
TARP TCR gamma alternate reading frame protein
TCHH trichohyalin
TET3 tet methylcytosine dioxygenase 3
TICAM1 toll-like receptor adaptor molecule 1
TMEM120B transmembrane protein 120B
TMEM57 transmembrane protein 57
TRDMT1 tRNA aspartic acid methyltransferase 1
TTLL1 tubulin tyrosine ligase-like family member 1
UNC119 unc-119 homolog (C. elegans)
UPK3B uroplakin 3B
URM1 ubiquitin related modifier 1
VASH2 vasohibin 2
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
WNT10B wingless-type MMTV integration site family, member 10B
ZBTB25 zinc finger and BTB domain containing 25
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF205 zinc finger protein 205
ZNF747 zinc finger protein 747