itch Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description itchy E3 ubiquitin protein ligase|This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] (NCBI Entrez Gene Database, 83737)
Similar Terms
Downloads & Tools

Genes

41 genes co-occuring with the biological term itch in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AMOT angiomotin
ARTN artemin
CALCA calcitonin-related polypeptide alpha
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CFLAR CASP8 and FADD-like apoptosis regulator
CRH corticotropin releasing hormone
DVL2 dishevelled segment polarity protein 2
ECE1 endothelin converting enzyme 1
EDNRB endothelin receptor type B
FOXP3 forkhead box P3
GBA glucosidase, beta, acid
IL31 interleukin 31
IL31RA interleukin 31 receptor A
ITCH itchy E3 ubiquitin protein ligase
LAPTM5 lysosomal protein transmembrane 5
LATS1 large tumor suppressor kinase 1
LITAF lipopolysaccharide-induced TNF factor
MAPK8 mitogen-activated protein kinase 8
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIR106B microRNA 106b
NDFIP1 Nedd4 family interacting protein 1
NDFIP2 Nedd4 family interacting protein 2
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFE2 nuclear factor, erythroid 2
NUMB numb homolog (Drosophila)
POU5F1 POU class 5 homeobox 1
PTCH1 patched 1
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RNF11 ring finger protein 11
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6
SNX9 sorting nexin 9
TLR7 toll-like receptor 7
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TP53BP2 tumor protein p53 binding protein 2
TP73 tumor protein p73
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV3 transient receptor potential cation channel, subfamily V, member 3
TXNIP thioredoxin interacting protein
USP9X ubiquitin specific peptidase 9, X-linked
YAP1 Yes-associated protein 1