integrin, alpha 5 (fibronectin receptor, alpha polypeptide)|The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 and integrin alpha V chains are produced by distinct genes. [provided by RefSeq, Jan 2015] (NCBI Entrez Gene Database, 3678)
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9 genes co-occuring with the biological term itga5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
