jak2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Janus kinase 2|This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3717)
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Genes

158 genes co-occuring with the biological term jak2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADIPOQ adiponectin, C1Q and collagen domain containing
AHI1 Abelson helper integration site 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
APOA1 apolipoprotein A-I
ASGR1 asialoglycoprotein receptor 1
ASXL1 additional sex combs like transcriptional regulator 1
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
AURKA aurora kinase A
BAD BCL2-associated agonist of cell death
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL6 B-cell CLL/lymphoma 6
BCR breakpoint cluster region
CALR calreticulin
CAPN1 calpain 1, (mu/I) large subunit
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX5 chromobox homolog 5
CCL21 chemokine (C-C motif) ligand 21
CCL3 chemokine (C-C motif) ligand 3
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CCR6 chemokine (C-C motif) receptor 6
CD24 CD24 molecule
CD274 CD274 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CLCN2 chloride channel, voltage-sensitive 2
CRLF2 cytokine receptor-like factor 2
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CSK c-src tyrosine kinase
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
EGFR epidermal growth factor receptor
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EPOR erythropoietin receptor
ESR1 estrogen receptor 1
ETV6 ets variant 6
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
FGF2 fibroblast growth factor 2 (basic)
FH fumarate hydratase
FIP1L1 factor interacting with PAPOLA and CPSF1
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLNA filamin A, alpha
FLT3 fms-related tyrosine kinase 3
FLT4 fms-related tyrosine kinase 4
GCH1 GTP cyclohydrolase 1
GH1 growth hormone 1
GHR growth hormone receptor
GSK3B glycogen synthase kinase 3 beta
HAMP hepcidin antimicrobial peptide
HAS2 hyaluronan synthase 2
HFE hemochromatosis
HLA-G major histocompatibility complex, class I, G
HNF4A hepatocyte nuclear factor 4, alpha
HSPA4 heat shock 70kDa protein 4
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFNG interferon, gamma
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10 interleukin 10
IL12A interleukin 12A
IL12B interleukin 12B
IL13 interleukin 13
IL1B interleukin 1, beta
IL5 interleukin 5
IL6 interleukin 6
IL6R interleukin 6 receptor
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LEP leptin
LGALS1 lectin, galactoside-binding, soluble, 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAPK1 mitogen-activated protein kinase 1
MAPK8 mitogen-activated protein kinase 8
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIR375 microRNA 375
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MPL MPL proto-oncogene, thrombopoietin receptor
MUC16 mucin 16, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCF1 neutrophil cytosolic factor 1
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NIN ninein (GSK3B interacting protein)
NOX4 NADPH oxidase 4
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
OSM oncostatin M
OSMR oncostatin M receptor
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PML promyelocytic leukemia
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRL prolactin
PRLR prolactin receptor
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RET ret proto-oncogene
RUNX1 runt-related transcription factor 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SET SET nuclear proto-oncogene
SH2B1 SH2B adaptor protein 1
SH2B3 SH2B adaptor protein 3
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19
SOCS1 suppressor of cytokine signaling 1
SOCS2 suppressor of cytokine signaling 2
SOCS3 suppressor of cytokine signaling 3
SPI1 Spi-1 proto-oncogene
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF2 serine/arginine-rich splicing factor 2
STAR steroidogenic acute regulatory protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TERT telomerase reverse transcriptase
TET2 tet methylcytosine dioxygenase 2
THPO thrombopoietin
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TSLP thymic stromal lymphopoietin
U2AF1 U2 small nuclear RNA auxiliary factor 1