jak3 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Janus kinase 3|The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3718)
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Genes

36 genes co-occuring with the biological term jak3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADIPOQ adiponectin, C1Q and collagen domain containing
ALK anaplastic lymphoma receptor tyrosine kinase
CD247 CD247 molecule
CXCL12 chemokine (C-X-C motif) ligand 12
EGFR epidermal growth factor receptor
ELAVL1 ELAV like RNA binding protein 1
FLT3 fms-related tyrosine kinase 3
IL12A interleukin 12A
IL12B interleukin 12B
IL13 interleukin 13
IL2 interleukin 2
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL9R interleukin 9 receptor
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LYN LYN proto-oncogene, Src family tyrosine kinase
MPL MPL proto-oncogene, thrombopoietin receptor
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR0B2 nuclear receptor subfamily 0, group B, member 2
OSM oncostatin M
PLD2 phospholipase D2
PML promyelocytic leukemia
PTPN6 protein tyrosine phosphatase, non-receptor type 6
SETBP1 SET binding protein 1
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SOCS3 suppressor of cytokine signaling 3
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
TSLP thymic stromal lymphopoietin
TYK2 tyrosine kinase 2
VEGFA vascular endothelial growth factor A