kawain-4693 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the kawain-4693 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADAM22 ADAM metallopeptidase domain 22
ADGRG2 adhesion G protein-coupled receptor G2
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
ALCAM activated leukocyte cell adhesion molecule
ALOX15 arachidonate 15-lipoxygenase
ARMC4 armadillo repeat containing 4
BCO1 beta-carotene oxygenase 1
BMP1 bone morphogenetic protein 1
C19ORF66 chromosome 19 open reading frame 66
CCDC121 coiled-coil domain containing 121
CCDC186 coiled-coil domain containing 186
CCDC68 coiled-coil domain containing 68
CDC14A cell division cycle 14A
CDC25C cell division cycle 25C
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDRT1 CMT1A duplicated region transcript 1
CELF2 CUGBP, Elav-like family member 2
CLEC3B C-type lectin domain family 3, member B
CREM cAMP responsive element modulator
CRLF2 cytokine receptor-like factor 2
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOCK6 dedicator of cytokinesis 6
DXO decapping exoribonuclease
EDN1 endothelin 1
FADS2 fatty acid desaturase 2
FAS Fas cell surface death receptor
FCMR Fc fragment of IgM receptor
FHL1 four and a half LIM domains 1
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPER1 G protein-coupled estrogen receptor 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IL11 interleukin 11
ISG15 ISG15 ubiquitin-like modifier
ITPK1 inositol-tetrakisphosphate 1-kinase
KDM4B lysine (K)-specific demethylase 4B
KIAA1109 KIAA1109
LAMP1 lysosomal-associated membrane protein 1
LIG3 ligase III, DNA, ATP-dependent
LIMK2 LIM domain kinase 2
LIN7A lin-7 homolog A (C. elegans)
LPIN1 lipin 1
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MVB12B multivesicular body subunit 12B
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NR2E3 nuclear receptor subfamily 2, group E, member 3
NRL neural retina leucine zipper
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PAOX polyamine oxidase (exo-N4-amino)
PARVA parvin, alpha
PCDHA6 protocadherin alpha 6
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PHLDB1 pleckstrin homology-like domain, family B, member 1
PRAMEF12 PRAME family member 12
PRDM2 PR domain containing 2, with ZNF domain
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RNF6 ring finger protein (C3H2C3 type) 6
SAP30 Sin3A-associated protein, 30kDa
SCAND2P SCAN domain containing 2 pseudogene
SCGB2A2 secretoglobin, family 2A, member 2
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SPRED2 sprouty-related, EVH1 domain containing 2
SRSF7 serine/arginine-rich splicing factor 7
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STRN3 striatin, calmodulin binding protein 3
TAPBP TAP binding protein (tapasin)
TBC1D2B TBC1 domain family, member 2B
TESK1 testis-specific kinase 1
THBS1 thrombospondin 1
TRD T cell receptor delta locus
TRIM2 tripartite motif containing 2
TXNL4A thioredoxin-like 4A
UBTD1 ubiquitin domain containing 1
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
WNT5A wingless-type MMTV integration site family, member 5A
XAF1 XIAP associated factor 1
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
YIPF4 Yip1 domain family, member 4
YY2 YY2 transcription factor
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF286A zinc finger protein 286A
ZNF304 zinc finger protein 304
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
C7ORF69 chromosome 7 open reading frame 69
CAMK1 calcium/calmodulin-dependent protein kinase I
CCDC69 coiled-coil domain containing 69
CENPO centromere protein O
CENPQ centromere protein Q
CGA glycoprotein hormones, alpha polypeptide
CHRM3 cholinergic receptor, muscarinic 3
CLSPN claspin
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CORT cortistatin
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNM1 dynamin 1
DVL1 dishevelled segment polarity protein 1
ELSPBP1 epididymal sperm binding protein 1
ERMAP erythroblast membrane-associated protein (Scianna blood group)
EYA3 EYA transcriptional coactivator and phosphatase 3
FEM1C fem-1 homolog c (C. elegans)
FILIP1L filamin A interacting protein 1-like
FLJ21369 uncharacterized protein FLJ21369
FLT4 fms-related tyrosine kinase 4
FURIN furin (paired basic amino acid cleaving enzyme)
FUZ fuzzy planar cell polarity protein
GADD45G growth arrest and DNA-damage-inducible, gamma
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLRA1 glycine receptor, alpha 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GRB7 growth factor receptor-bound protein 7
HCFC2 host cell factor C2
HIST1H2BN histone cluster 1, H2bn
HIST1H3B histone cluster 1, H3b
HLA-J major histocompatibility complex, class I, J (pseudogene)
HOXC8 homeobox C8
HPN hepsin
IFT140 intraflagellar transport 140
IL12RB1 interleukin 12 receptor, beta 1
INF2 inverted formin, FH2 and WH2 domain containing
IPO8 importin 8
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KIAA0319L KIAA0319-like
KIF13A kinesin family member 13A
KREMEN2 kringle containing transmembrane protein 2
KRT31 keratin 31, type I
LRRC37A2 leucine rich repeat containing 37, member A2
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MYLK myosin light chain kinase
NAG18 NAG18 mRNA
NAT6 N-acetyltransferase 6 (GCN5-related)
NEUROD1 neuronal differentiation 1
NOL10 nucleolar protein 10
NPFFR1 neuropeptide FF receptor 1
NPTX1 neuronal pentraxin I
OCEL1 occludin/ELL domain containing 1
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PAIP2B poly(A) binding protein interacting protein 2B
PHC1 polyhomeotic homolog 1 (Drosophila)
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PLAT plasminogen activator, tissue
PMCH pro-melanin-concentrating hormone
PMEL premelanosome protein
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRSS53 protease, serine, 53
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RGS20 regulator of G-protein signaling 20
RIN1 Ras and Rab interactor 1
RNF208 ring finger protein 208
RNF25 ring finger protein 25
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RUSC2 RUN and SH3 domain containing 2
S100A9 S100 calcium binding protein A9
SAA3P serum amyloid A3 pseudogene
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SND1-IT1 SND1 intronic transcript 1
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STEAP4 STEAP family member 4
STIM1 stromal interaction molecule 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TLN1 talin 1
TMEM212 transmembrane protein 212
TMEM53 transmembrane protein 53
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRAPPC13 trafficking protein particle complex 13
TSC1 tuberous sclerosis 1
TTLL1 tubulin tyrosine ligase-like family member 1
TUBB2B tubulin, beta 2B class IIb
UNC93B1 unc-93 homolog B1 (C. elegans)
VEGFC vascular endothelial growth factor C
VGF VGF nerve growth factor inducible
ZNF205 zinc finger protein 205
ZNF254 zinc finger protein 254
ZNF747 zinc finger protein 747