| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/45258277 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in kb NB 142-70 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CDC37 | cell division cycle 37 | 3.35 |
| CDCA5 | cell division cycle associated 5 | 2.64 |
| TP53 | tumor protein p53 | 2.34 |
| ATF3 | activating transcription factor 3 | 2.28 |
| CLK1 | CDC-like kinase 1 | 2.27 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 2.25 |
| ICAM5 | intercellular adhesion molecule 5, telencephalin | 2.18 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 2.18 |
| CDC25A | cell division cycle 25A | 2.03 |
| CCND3 | cyclin D3 | 1.93 |
| WDR53 | WD repeat domain 53 | 1.9 |
| PER1 | period circadian clock 1 | 1.9 |
| CLK3 | CDC-like kinase 3 | 1.9 |
| SESN2 | sestrin 2 | 1.89 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 1.87 |
| POLR1D | polymerase (RNA) I polypeptide D, 16kDa | 1.79 |
| TRIM35 | tripartite motif containing 35 | 1.78 |
| TPX2 | TPX2, microtubule-associated | 1.73 |
| ZSWIM9 | zinc finger SWIM-type containing 9 | 1.7 |
| FBXL8 | F-box and leucine-rich repeat protein 8 | 1.69 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | 1.68 |
| FRS2 | fibroblast growth factor receptor substrate 2 | 1.65 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | 1.6 |
| CCND1 | cyclin D1 | 1.59 |
| NCOA4 | nuclear receptor coactivator 4 | 1.59 |
| ZNF408 | zinc finger protein 408 | 1.59 |
| TMUB1 | transmembrane and ubiquitin-like domain containing 1 | 1.54 |
| ANKRD10 | ankyrin repeat domain 10 | 1.54 |
| CDK9 | cyclin-dependent kinase 9 | 1.51 |
| E2F7 | E2F transcription factor 7 | 1.49 |
| MRM2 | mitochondrial rRNA methyltransferase 2 | 1.49 |
| RBM4 | RNA binding motif protein 4 | 1.49 |
| EGR1 | early growth response 1 | 1.47 |
| MTG2 | mitochondrial ribosome-associated GTPase 2 | 1.47 |
| ZNF121 | zinc finger protein 121 | 1.46 |
| ASB6 | ankyrin repeat and SOCS box containing 6 | 1.44 |
| IRS2 | insulin receptor substrate 2 | 1.42 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | 1.42 |
| SIRT7 | sirtuin 7 | 1.42 |
| JUN | jun proto-oncogene | 1.42 |
| ZBTB17 | zinc finger and BTB domain containing 17 | 1.41 |
| CCNT1 | cyclin T1 | 1.41 |
| CBLL1 | Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase | 1.4 |
| ORC1 | origin recognition complex, subunit 1 | 1.38 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 1.37 |
| RND3 | Rho family GTPase 3 | 1.34 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 1.34 |
| ZNF451 | zinc finger protein 451 | 1.32 |
| CCNE1 | cyclin E1 | 1.32 |
| AEN | apoptosis enhancing nuclease | 1.32 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) | 1.32 |
| PRG4 | proteoglycan 4 | 1.3 |
| SLBP | stem-loop binding protein | 1.29 |
| YRDC | yrdC N(6)-threonylcarbamoyltransferase domain containing | 1.29 |
| ZBTB24 | zinc finger and BTB domain containing 24 | 1.26 |
| CHPF2 | chondroitin polymerizing factor 2 | 1.24 |
| PHLDA3 | pleckstrin homology-like domain, family A, member 3 | 1.24 |
| MSANTD2 | Myb/SANT-like DNA-binding domain containing 2 | 1.24 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 1.23 |
| TAGLN | transgelin | 1.23 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | 1.22 |
| GMNN | geminin, DNA replication inhibitor | 1.22 |
| TMEM11 | transmembrane protein 11 | 1.21 |
| RHOD | ras homolog family member D | 1.19 |
| FOXM1 | forkhead box M1 | 1.16 |
| PUF60 | poly-U binding splicing factor 60KDa | 1.16 |
| ZRSR2 | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 | 1.16 |
| SIVA1 | SIVA1, apoptosis-inducing factor | 1.16 |
| COASY | CoA synthase | 1.15 |
| TRIB1 | tribbles pseudokinase 1 | 1.14 |
| TK1 | thymidine kinase 1, soluble | 1.14 |
| C4BPA | complement component 4 binding protein, alpha | 1.13 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 1.13 |
| NDOR1 | NADPH dependent diflavin oxidoreductase 1 | 1.12 |
| ZNF544 | zinc finger protein 544 | 1.12 |
| MED26 | mediator complex subunit 26 | 1.11 |
| RNASE4 | ribonuclease, RNase A family, 4 | 1.11 |
| ZNF524 | zinc finger protein 524 | 1.1 |
| LINS1 | lines homolog 1 | 1.1 |
| SETD5 | SET domain containing 5 | 1.1 |
| UPF3A | UPF3 regulator of nonsense transcripts homolog A (yeast) | 1.1 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | 1.07 |
| COL14A1 | collagen, type XIV, alpha 1 | 1.06 |
| AAR2 | AAR2 splicing factor homolog (S. cerevisiae) | 1.06 |
| WTAP | Wilms tumor 1 associated protein | 1.06 |
| SMTN | smoothelin | 1.06 |
| FTH1 | ferritin, heavy polypeptide 1 | 1.05 |
| CHMP2A | charged multivesicular body protein 2A | 1.05 |
| KBTBD8 | kelch repeat and BTB (POZ) domain containing 8 | 1.05 |
| UNG | uracil-DNA glycosylase | 1.05 |
| SNIP1 | Smad nuclear interacting protein 1 | 1.05 |
| SPTY2D1 | SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) | 1.04 |
| ZNF267 | zinc finger protein 267 | 1.04 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | 1.03 |
| MAGEA2 | melanoma antigen family A2 | 1.02 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | 1.01 |
| ZNF787 | zinc finger protein 787 | 1.0 |
| ZNF304 | zinc finger protein 304 | 1.0 |
| MAP4 | microtubule-associated protein 4 | 0.99 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SPRTN | SprT-like N-terminal domain | -5.49 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -3.27 |
| HOXA9 | homeobox A9 | -3.27 |
| ZNF770 | zinc finger protein 770 | -3.26 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -3.13 |
| MT2A | metallothionein 2A | -3.12 |
| TRAIP | TRAF interacting protein | -2.87 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -2.78 |
| RTL8C | retrotransposon Gag like 8C | -2.77 |
| ZNF552 | zinc finger protein 552 | -2.53 |
| CBLC | Cbl proto-oncogene C, E3 ubiquitin protein ligase | -2.49 |
| ODC1 | ornithine decarboxylase 1 | -2.4 |
| TRIM44 | tripartite motif containing 44 | -2.38 |
| FNIP1 | folliculin interacting protein 1 | -2.35 |
| TRIM62 | tripartite motif containing 62 | -2.33 |
| MLPH | melanophilin | -2.28 |
| KMT5A | lysine methyltransferase 5A | -2.25 |
| RNF145 | ring finger protein 145 | -2.22 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -2.21 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | -2.09 |
| RAD51AP1 | RAD51 associated protein 1 | -2.06 |
| PCDHGA10 | protocadherin gamma subfamily A, 10 | -2.04 |
| ZBTB33 | zinc finger and BTB domain containing 33 | -2.03 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -2.03 |
| RNF187 | ring finger protein 187 | -2.02 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | -2.0 |
| BRCA2 | breast cancer 2, early onset | -1.98 |
| C6ORF62 | chromosome 6 open reading frame 62 | -1.97 |
| RPAP2 | RNA polymerase II associated protein 2 | -1.96 |
| NABP1 | nucleic acid binding protein 1 | -1.95 |
| JOSD1 | Josephin domain containing 1 | -1.93 |
| SNX10 | sorting nexin 10 | -1.92 |
| ZNF664 | zinc finger protein 664 | -1.91 |
| SYTL3 | synaptotagmin-like 3 | -1.9 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -1.89 |
| RGS3 | regulator of G-protein signaling 3 | -1.88 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -1.88 |
| RNF181 | ring finger protein 181 | -1.85 |
| SAPCD2 | suppressor APC domain containing 2 | -1.84 |
| AFF1 | AF4/FMR2 family, member 1 | -1.83 |
| SKIL | SKI-like proto-oncogene | -1.83 |
| TPGS1 | tubulin polyglutamylase complex subunit 1 | -1.81 |
| SLC10A4 | solute carrier family 10, member 4 | -1.8 |
| LSM11 | LSM11, U7 small nuclear RNA associated | -1.8 |
| RSAD1 | radical S-adenosyl methionine domain containing 1 | -1.79 |
| DZIP3 | DAZ interacting zinc finger protein 3 | -1.78 |
| PLAU | plasminogen activator, urokinase | -1.77 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -1.77 |
| LMO4 | LIM domain only 4 | -1.77 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -1.76 |
| ATXN7L3B | ataxin 7-like 3B | -1.75 |
| ZBTB40 | zinc finger and BTB domain containing 40 | -1.75 |
| WSB1 | WD repeat and SOCS box containing 1 | -1.74 |
| CCDC170 | coiled-coil domain containing 170 | -1.74 |
| MTBP | MDM2 binding protein | -1.74 |
| ESCO2 | establishment of sister chromatid cohesion N-acetyltransferase 2 | -1.74 |
| ZUP1 | zinc finger containing ubiquitin peptidase 1 | -1.73 |
| ERVMER34-1 | endogenous retrovirus group MER34, member 1 | -1.72 |
| TTC31 | tetratricopeptide repeat domain 31 | -1.72 |
| TNS4 | tensin 4 | -1.71 |
| SOX13 | SRY (sex determining region Y)-box 13 | -1.7 |
| ANKRD36 | ankyrin repeat domain 36 | -1.7 |
| SPRYD3 | SPRY domain containing 3 | -1.69 |
| FOXO1 | forkhead box O1 | -1.69 |
| UBE2W | ubiquitin-conjugating enzyme E2W (putative) | -1.69 |
| ARL4A | ADP-ribosylation factor-like 4A | -1.67 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -1.67 |
| F2R | coagulation factor II (thrombin) receptor | -1.65 |
| PRR3 | proline rich 3 | -1.65 |
| HOMEZ | homeobox and leucine zipper encoding | -1.65 |
| ZNF397 | zinc finger protein 397 | -1.65 |
| ZNF335 | zinc finger protein 335 | -1.65 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -1.65 |
| LRIF1 | ligand dependent nuclear receptor interacting factor 1 | -1.63 |
| RAD51 | RAD51 recombinase | -1.62 |
| CCDC77 | coiled-coil domain containing 77 | -1.62 |
| DYNC2LI1 | dynein, cytoplasmic 2, light intermediate chain 1 | -1.62 |
| EXO1 | exonuclease 1 | -1.62 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -1.61 |
| SMAD1 | SMAD family member 1 | -1.61 |
| ETNK1 | ethanolamine kinase 1 | -1.6 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -1.59 |
| IVNS1ABP | influenza virus NS1A binding protein | -1.59 |
| QKI | QKI, KH domain containing, RNA binding | -1.58 |
| NOTCH3 | notch 3 | -1.58 |
| ARMCX5 | armadillo repeat containing, X-linked 5 | -1.58 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -1.57 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -1.57 |
| KLHDC2 | kelch domain containing 2 | -1.57 |
| GRB7 | growth factor receptor-bound protein 7 | -1.57 |
| BRCA1 | breast cancer 1, early onset | -1.56 |
| FBXL3 | F-box and leucine-rich repeat protein 3 | -1.56 |
| DNAJB5 | DnaJ (Hsp40) homolog, subfamily B, member 5 | -1.56 |
| FRMD6 | FERM domain containing 6 | -1.56 |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | -1.56 |
| GLT8D1 | glycosyltransferase 8 domain containing 1 | -1.54 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -1.54 |
| RPGRIP1L | RPGRIP1-like | -1.53 |
| CIZ1 | CDKN1A interacting zinc finger protein 1 | -1.53 |
