keap1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description kelch-like ECH-associated protein 1|This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9817)
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Genes

30 genes co-occuring with the biological term keap1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AMER1 APC membrane recruitment protein 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BPTF bromodomain PHD finger transcription factor
CUL1 cullin 1
CUL3 cullin 3
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMOX1 heme oxygenase 1
KEAP1 kelch-like ECH-associated protein 1
KLHDC1 kelch domain containing 1
KMT2D lysine (K)-specific methyltransferase 2D
KPNA6 karyopherin alpha 6 (importin alpha 7)
MIR141 microRNA 141
MIR200A microRNA 200a
NFE2L2 nuclear factor, erythroid 2-like 2
NQO1 NAD(P)H dehydrogenase, quinone 1
PGAM5 phosphoglycerate mutase family member 5
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PPARG peroxisome proliferator-activated receptor gamma
PRDX4 peroxiredoxin 4
PTEN phosphatase and tensin homolog
PTMA prothymosin, alpha
RB1 retinoblastoma 1
RBX1 ring-box 1, E3 ubiquitin protein ligase
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
SIAH2 siah E3 ubiquitin protein ligase 2
SP1 Sp1 transcription factor
SQSTM1 sequestosome 1
TP53 tumor protein p53
USP15 ubiquitin specific peptidase 15