keloid Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description A tough heaped-up scar that rises quite abruptly above the rest of the skin. It is irregularly shaped and tends to enlarge progressively. Keloids arise when there is too much collagen formed in the dermis during the repair of connective tissue. (BRENDA Tissue and Enzyme Source Ontology, BTO_0003669)
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Genes

192 proteins co-occuring with the tissue keloid in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
GDF6 growth differentiation factor 6 2.51084
TGFB1 transforming growth factor, beta 1 1.76024
SMAD2 SMAD family member 2 1.42091
FN1 fibronectin 1 1.41261
CTGF connective tissue growth factor 1.40662
RRP1 ribosomal RNA processing 1 1.38459
SMAD7 SMAD family member 7 1.30748
SMAD3 SMAD family member 3 1.27561
MMP1 matrix metallopeptidase 1 1.23361
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 1.16027
NREP neuronal regeneration related protein 1.14033
COL1A2 collagen, type I, alpha 2 1.07662
CD34 CD34 molecule 1.0603
TGFB2 transforming growth factor, beta 2 1.012
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.985425
IFNA2 interferon, alpha 2 0.951685
MAP3K15 mitogen-activated protein kinase kinase kinase 15 0.943505
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.942645
TNC tenascin C 0.906256
TP53 tumor protein p53 0.902424
TGFB3 transforming growth factor, beta 3 0.900721
DCN decorin 0.879935
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.855891
SKOR1 SKI family transcriptional corepressor 1 0.846225
MMP2 matrix metallopeptidase 2 0.836575
COL1A1 collagen, type I, alpha 1 0.836156
COL6A2 collagen, type VI, alpha 2 0.825268
FGF2 fibroblast growth factor 2 (basic) 0.786468
SMAD4 SMAD family member 4 0.784804
SFN stratifin 0.775249
CDSN corneodesmosin 0.758673
TIMP1 TIMP metallopeptidase inhibitor 1 0.747102
FBN1 fibrillin 1 0.742152
ECM2 extracellular matrix protein 2, female organ and adipocyte specific 0.739678
KIAA0226 KIAA0226 0.724453
PCNA proliferating cell nuclear antigen 0.694946
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.68188
SFRP2 secreted frizzled-related protein 2 0.667622
COMP cartilage oligomeric matrix protein 0.654212
INHBA inhibin, beta A 0.652994
PCOLCE procollagen C-endopeptidase enhancer 0.652994
CNN2 calponin 2 0.651371
COL3A1 collagen, type III, alpha 1 0.65056
CD68 CD68 molecule 0.647721
TPSAB1 tryptase alpha/beta 1 0.643669
CDK10 cyclin-dependent kinase 10 0.641238
IL24 interleukin 24 0.626677
KRT75 keratin 75, type II 0.625061
PSMC3IP PSMC3 interacting protein 0.621831
FBLN5 fibulin 5 0.616183
MT1B metallothionein 1B 0.60249
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.601686
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.595656
COL6A1 collagen, type VI, alpha 1 0.59124
DPT dermatopontin 0.580818
POSTN periostin, osteoblast specific factor 0.574017
MMP9 matrix metallopeptidase 9 0.569622
AVEN apoptosis, caspase activation inhibitor 0.567227
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.560847
DDR1 discoidin domain receptor tyrosine kinase 1 0.546929
RPS18P12 ribosomal protein S18 pseudogene 12 0.54217
RPS18 ribosomal protein S18 0.537812
MLEC malectin 0.535438
VCAN versican 0.53346
PTER phosphotriesterase related 0.530298
CER1 cerberus 1, DAN family BMP antagonist 0.520041
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 0.509027
SMAD6 SMAD family member 6 0.508635
IL11RA interleukin 11 receptor, alpha 0.506279
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.505887
HAS3 hyaluronan synthase 3 0.504318
MMP3 matrix metallopeptidase 3 0.500398
IGF1 insulin-like growth factor 1 (somatomedin C) 0.493745
JUN jun proto-oncogene 0.492963
TFG TRK-fused gene 0.487106
ASPN asporin 0.477756
MATN2 matrilin 2 0.47348
RSPO2 R-spondin 2 0.471151
KLF7 Kruppel-like factor 7 (ubiquitous) 0.464174
CALD1 caldesmon 1 0.461852
IGF1R insulin-like growth factor 1 receptor 0.461078
SLC39A6 solute carrier family 39 (zinc transporter), member 6 0.460305
CBR3 carbonyl reductase 3 0.460305
IL1B interleukin 1, beta 0.457987
FOXO4 forkhead box O4 0.45567
KRT2 keratin 2, type II 0.454126
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.444499
S100A9 S100 calcium binding protein A9 0.442578
CTHRC1 collagen triple helix repeat containing 1 0.440274
CREBBP CREB binding protein 0.439123
ATF2 activating transcription factor 2 0.426109
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 0.426109
MMP24 matrix metallopeptidase 24 (membrane-inserted) 0.424581
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.424199
TIMP2 TIMP metallopeptidase inhibitor 2 0.415814
AVIL advillin 0.415434
APITD1 apoptosis-inducing, TAF9-like domain 1 0.413532
THBS1 thrombospondin 1 0.410111
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.408592
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.387027
BGN biglycan 0.38439
IL6 interleukin 6 0.383637
LOX lysyl oxidase 0.381379
ADAM33 ADAM metallopeptidase domain 33 0.381003
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 0.378748
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.378748
PIAS2 protein inhibitor of activated STAT, 2 0.377996
COL6A3 collagen, type VI, alpha 3 0.377621
FAP fibroblast activation protein, alpha 0.371245
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.370121
BCL2 B-cell CLL/lymphoma 2 0.36825
MMP13 matrix metallopeptidase 13 0.367502
TSPAN8 tetraspanin 8 0.367129
ANXA2 annexin A2 0.361901
APOL1 apolipoprotein L, 1 0.356686
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 0.352598
MYO1E myosin IE 0.348889
HLA-C major histocompatibility complex, class I, C 0.348519
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 0.33965
COL14A1 collagen, type XIV, alpha 1 0.33744
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.336704
DPP4 dipeptidyl-peptidase 4 0.33156
MFAP2 microfibrillar-associated protein 2 0.33046
SFRP1 secreted frizzled-related protein 1 0.329727
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.325335
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 0.322414
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.322414
MMP8 matrix metallopeptidase 8 0.319134
DPP9 dipeptidyl-peptidase 9 0.318407
ACOT13 acyl-CoA thioesterase 13 0.316951
CASP14 caspase 14, apoptosis-related cysteine peptidase 0.315498
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.312957
RUNX3 runt-related transcription factor 3 0.303559
F8 coagulation factor VIII, procoagulant component 0.303559
IFNA1 interferon, alpha 1 0.302478
MALL mal, T-cell differentiation protein-like 0.301398
NOX3 NADPH oxidase 3 0.30032
HBA1 hemoglobin, alpha 1 0.298165
COL5A1 collagen, type V, alpha 1 0.297089
HAVCR1 hepatitis A virus cellular receptor 1 0.293508
HBA2 hemoglobin, alpha 2 0.286381
MT1A metallothionein 1A 0.283899
DPP8 dipeptidyl-peptidase 8 0.280717
IL6R interleukin 6 receptor 0.278251
PLG plasminogen 0.275794
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.275094
SIRT7 sirtuin 7 0.270214
PGLS 6-phosphogluconolactonase 0.262645
HDGF hepatoma-derived growth factor 0.262304
SHOX short stature homeobox 0.262304
NOV nephroblastoma overexpressed 0.260267
OSM oncostatin M 0.259254
GAS1 growth arrest-specific 1 0.256568
CDK11A cyclin-dependent kinase 11A 0.256234
FSTL3 follistatin-like 3 (secreted glycoprotein) 0.25259
FGF1 fibroblast growth factor 1 (acidic) 0.25259
BAX BCL2-associated X protein 0.252261
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.251934
ESM1 endothelial cell-specific molecule 1 0.251606
MMP19 matrix metallopeptidase 19 0.250953
DYNLL1 dynein, light chain, LC8-type 1 0.247719
DDR2 discoidin domain receptor tyrosine kinase 2 0.24676
BMX BMX non-receptor tyrosine kinase 0.245807
G6PD glucose-6-phosphate dehydrogenase 0.243605
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.242672
TNF tumor necrosis factor 0.242672
TNXA tenascin XA (pseudogene) 0.242363
TNXB tenascin XB 0.242054
MIR31 microRNA 31 0.241132
SP6 Sp6 transcription factor 0.23781
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.236921
IL10 interleukin 10 0.236627
THY1 Thy-1 cell surface antigen 0.236332
PLAU plasminogen activator, urokinase 0.234302
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.233731
MAPK8 mitogen-activated protein kinase 8 0.232881
ANXA5 annexin A5 0.232599
NF1 neurofibromin 1 0.229299
MIR21 microRNA 21 0.227445
ACTB actin, beta 0.226411
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.225647
IL18BP interleukin 18 binding protein 0.223177
TGFBR1 transforming growth factor, beta receptor 1 0.220604
S100A4 S100 calcium binding protein A4 0.219485
OMD osteomodulin 0.219264
IGFBP5 insulin-like growth factor binding protein 5 0.218186
ITGA1 integrin, alpha 1 0.217554
USP9X ubiquitin specific peptidase 9, X-linked 0.21573
ACTG1 actin gamma 1 0.215534
CMA1 chymase 1, mast cell 0.215534
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.214017
SPHK2 sphingosine kinase 2 0.213833