keratinocyte Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Skin cell, of the keratinized layer of epidermis: its characteristic intermediate filament protein is cytokeratin. A cell of the stratum spinosum of the epidermis. (BRENDA Tissue and Enzyme Source Ontology, BTO_0000667)
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Genes

328 genes co-occuring with the biological term keratinocyte in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD5 abhydrolase domain containing 5
ADAM10 ADAM metallopeptidase domain 10
ADAM12 ADAM metallopeptidase domain 12
ADAM17 ADAM metallopeptidase domain 17
ADD1 adducin 1 (alpha)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRB2 adrenoceptor beta 2, surface
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALDOA aldolase A, fructose-bisphosphate
ALOX12 arachidonate 12-lipoxygenase
ALOX15 arachidonate 15-lipoxygenase
AQP3 aquaporin 3 (Gill blood group)
AR androgen receptor
AREG amphiregulin
ATM ATM serine/threonine kinase
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BIRC5 baculoviral IAP repeat containing 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
CALCA calcitonin-related polypeptide alpha
CAMP cathelicidin antimicrobial peptide
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CASP14 caspase 14, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CAV1 caveolin 1, caveolae protein, 22kDa
CCHCR1 coiled-coil alpha-helical rod protein 1
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CCND2 cyclin D2
CCND3 cyclin D3
CD14 CD14 molecule
CD1D CD1d molecule
CD44 CD44 molecule (Indian blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH13 cadherin 13
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFL1 cofilin 1 (non-muscle)
CHRM3 cholinergic receptor, muscarinic 3
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CHUK conserved helix-loop-helix ubiquitous kinase
CKAP4 cytoskeleton-associated protein 4
CLIC4 chloride intracellular channel 4
COL17A1 collagen, type XVII, alpha 1
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
CRABP1 cellular retinoic acid binding protein 1
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
CTSB cathepsin B
CTTN cortactin
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CYLD cylindromatosis (turban tumor syndrome)
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1
DCN decorin
DCTN1 dynactin 1
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DEC1 deleted in esophageal cancer 1
DEFB1 defensin, beta 1
DEFB103B defensin, beta 103B
DEFB4A defensin, beta 4A
DEGS2 delta(4)-desaturase, sphingolipid 2
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DSC3 desmocollin 3
DSG1 desmoglein 1
DSG2 desmoglein 2
DSG3 desmoglein 3
DSP desmoplakin
DST dystonin
EDN1 endothelin 1
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EGR1 early growth response 1
ELF5 E74-like factor 5 (ets domain transcription factor)
EPHB2 EPH receptor B2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB2IP erbb2 interacting protein
EREG epiregulin
F2R coagulation factor II (thrombin) receptor
FADD Fas (TNFRSF6)-associated via death domain
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FGF10 fibroblast growth factor 10
FGF7 fibroblast growth factor 7
FGFR2 fibroblast growth factor receptor 2
FLG filaggrin
FLNA filamin A, alpha
FOSL1 FOS-like antigen 1
FOXN1 forkhead box N1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
GJB6 gap junction protein, beta 6, 30kDa
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
GRHL2 grainyhead-like 2 (Drosophila)
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HAL histidine ammonia-lyase
HBEGF heparin-binding EGF-like growth factor
HDAC2 histone deacetylase 2
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HRAS Harvey rat sarcoma viral oncogene homolog
HRH1 histamine receptor H1
HRH4 histamine receptor H4
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSF1 heat shock transcription factor 1
HSP90AA2P heat shock protein 90kDa alpha (cytosolic), class A member 2, pseudogene
HSPB1 heat shock 27kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGFBP5 insulin-like growth factor binding protein 5
IL13 interleukin 13
IL17A interleukin 17A
IL17C interleukin 17C
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL20 interleukin 20
IL22 interleukin 22
IL22RA1 interleukin 22 receptor, alpha 1
IL24 interleukin 24
IL31 interleukin 31
IL4 interleukin 4
IL7 interleukin 7
ILK integrin-linked kinase
IRF6 interferon regulatory factor 6
ITGA1 integrin, alpha 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGA6 integrin, alpha 6
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB4 integrin, beta 4
IVL involucrin
JAG1 jagged 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
JUP junction plakoglobin
KAT2B K(lysine) acetyltransferase 2B
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
KLK1 kallikrein 1
KPRP keratinocyte proline-rich protein
KRT10 keratin 10, type I
KRT16 keratin 16, type I
KRT2 keratin 2, type II
KRT6A keratin 6A, type II
KRTDAP keratinocyte differentiation-associated protein
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LCE2B late cornified envelope 2B
LEP leptin
LGALS3 lectin, galactoside-binding, soluble, 3
LOX lysyl oxidase
LRP1 low density lipoprotein receptor-related protein 1
LYNX1 Ly6/neurotoxin 1
MAGEB2 melanoma antigen family B2
MAML1 mastermind-like 1 (Drosophila)
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK13 mitogen-activated protein kinase 13
MAPK14 mitogen-activated protein kinase 14
MCL1 myeloid cell leukemia 1
MED1 mediator complex subunit 1
MEP1A meprin A, alpha (PABA peptide hydrolase)
MEP1B meprin A, beta
MET MET proto-oncogene, receptor tyrosine kinase
MIR125B1 microRNA 125b-1
MIR146A microRNA 146a
MIR203A microRNA 203a
MIR21 microRNA 21
MIR27B microRNA 27b
MIR31 microRNA 31
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP21 matrix metallopeptidase 21
MMP28 matrix metallopeptidase 28
MMP9 matrix metallopeptidase 9
MVK mevalonate kinase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCOA3 nuclear receptor coactivator 3
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGFR nerve growth factor receptor
NNAT neuronatin
NOS2 nitric oxide synthase 2, inducible
NOTCH1 notch 1
NOX1 NADPH oxidase 1
NOX4 NADPH oxidase 4
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NRP1 neuropilin 1
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4
OVOL2 ovo-like zinc finger 2
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PADI3 peptidyl arginine deiminase, type III
PANX1 pannexin 1
PANX3 pannexin 3
PDGFB platelet-derived growth factor beta polypeptide
PIAS4 protein inhibitor of activated STAT, 4
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKN1 protein kinase N1
PLAU plasminogen activator, urokinase
PLCG1 phospholipase C, gamma 1
PNPLA4 patatin-like phospholipase domain containing 4
POMC proopiomelanocortin
POU2F3 POU class 2 homeobox 3
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRKD3 protein kinase D3
PRSS3 protease, serine, 3
PTEN phosphatase and tensin homolog
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTN pleiotrophin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RB1 retinoblastoma 1
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
REST RE1-silencing transcription factor
RHOA ras homolog family member A
RHOB ras homolog family member B
RIPK4 receptor-interacting serine-threonine kinase 4
RMDN3 regulator of microtubule dynamics 3
RND3 Rho family GTPase 3
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RORA RAR-related orphan receptor A
RSPO2 R-spondin 2
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDC1 syndecan 1
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SFN stratifin
SIRT2 sirtuin 2
SIRT3 sirtuin 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLURP1 secreted LY6/PLAUR domain containing 1
SNAI2 snail family zinc finger 2
SOCS3 suppressor of cytokine signaling 3
SP1 Sp1 transcription factor
SPINK9 serine peptidase inhibitor, Kazal type 9
SPP1 secreted phosphoprotein 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SQSTM1 sequestosome 1
SREBF1 sterol regulatory element binding transcription factor 1
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STX4 syntaxin 4
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
SUMO3 small ubiquitin-like modifier 3
TERT telomerase reverse transcriptase
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TGFBI transforming growth factor, beta-induced, 68kDa
TGM1 transglutaminase 1
THBD thrombomodulin
TIMP1 TIMP metallopeptidase inhibitor 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TMPRSS15 transmembrane protease, serine 15
TNF tumor necrosis factor
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TP53 tumor protein p53
TP63 tumor protein p63
TP73 tumor protein p73
TRAIP TRAF interacting protein
TRIM16 tripartite motif containing 16
TRIM32 tripartite motif containing 32
TRPA1 transient receptor potential cation channel, subfamily A, member 1
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPC4 transient receptor potential cation channel, subfamily C, member 4
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TRPV3 transient receptor potential cation channel, subfamily V, member 3
TSG101 tumor susceptibility 101
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VTN vitronectin
WIF1 WNT inhibitory factor 1
WNT5A wingless-type MMTV integration site family, member 5A