keratoconjunctivitis sicca Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
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Genes

208 genes co-occuring with the disease keratoconjunctivitis sicca in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
TNF tumor necrosis factor 1.311
LTF lactotransferrin 1.27999
PPP1R12A protein phosphatase 1, regulatory subunit 12A 1.18281
S100A7 S100 calcium binding protein A7 1.08244
HSPG2 heparan sulfate proteoglycan 2 1.08118
LYZ lysozyme 1.07698
GJB6 gap junction protein, beta 6, 30kDa 1.04041
TLR4 toll-like receptor 4 0.975903
IRAK4 interleukin-1 receptor-associated kinase 4 0.901567
VSIG4 V-set and immunoglobulin domain containing 4 0.871643
CASP14 caspase 14, apoptosis-related cysteine peptidase 0.866321
IL1B interleukin 1, beta 0.848307
CD4 CD4 molecule 0.813462
LYNX1 Ly6/neurotoxin 1 0.767576
IL6 interleukin 6 0.759416
AQP5 aquaporin 5 0.750457
STAB1 stabilin 1 0.747204
HMGB1 high mobility group box 1 0.742329
FLG filaggrin 0.741923
IFNA4 interferon, alpha 4 0.732191
PADI1 peptidyl arginine deiminase, type I 0.711183
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 0.705144
TGFB1 transforming growth factor, beta 1 0.692296
CD40 CD40 molecule, TNF receptor superfamily member 5 0.687491
HACD3 3-hydroxyacyl-CoA dehydratase 3 0.684692
IVL involucrin 0.682693
ADSL adenylosuccinate lyase 0.670333
TRIM21 tripartite motif containing 21 0.666358
IRAK1BP1 interleukin-1 receptor-associated kinase 1 binding protein 1 0.656441
RGPD1 RANBP2-like and GRIP domain containing 1 0.649718
TLR5 toll-like receptor 5 0.643404
NBAS neuroblastoma amplified sequence 0.631991
IL1A interleukin 1, alpha 0.631598
TLR3 toll-like receptor 3 0.622575
LACRT lacritin 0.619834
DNTT DNA nucleotidylexotransferase 0.608494
MED4 mediator complex subunit 4 0.607714
ITSN2 intersectin 2 0.592895
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.590948
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.58433
AOAH acyloxyacyl hydrolase (neutrophil) 0.579661
DGKQ diacylglycerol kinase, theta 110kDa 0.577327
PADI3 peptidyl arginine deiminase, type III 0.562558
ICAM1 intercellular adhesion molecule 1 0.561781
LOR loricrin 0.560616
MSR1 macrophage scavenger receptor 1 0.55712
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.554403
CCL2 chemokine (C-C motif) ligand 2 0.550522
S100A9 S100 calcium binding protein A9 0.549747
PHIP pleckstrin homology domain interacting protein 0.547807
CD274 CD274 molecule 0.542379
EDA ectodysplasin A 0.541992
MMP21 matrix metallopeptidase 21 0.540829
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.537731
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.529994
KLF4 Kruppel-like factor 4 (gut) 0.528835
CD79A CD79a molecule, immunoglobulin-associated alpha 0.523816
RANGAP1 Ran GTPase activating protein 1 0.523045
FASLG Fas ligand (TNF superfamily, member 6) 0.521502
BPIFA2 BPI fold containing family A, member 2 0.518805
PSIP1 PC4 and SFRS1 interacting protein 1 0.517649
TNPO3 transportin 3 0.517649
E2F7 E2F transcription factor 7 0.509959
DSG3 desmoglein 3 0.509576
RNASE7 ribonuclease, RNase A family, 7 0.507273
SASH1 SAM and SH3 domain containing 1 0.505739
MARVELD2 MARVEL domain containing 2 0.503824
MMP9 matrix metallopeptidase 9 0.502675
JAK2 Janus kinase 2 0.498849
CCL17 chemokine (C-C motif) ligand 17 0.498085
SCARF1 scavenger receptor class F, member 1 0.484364
MYD88 myeloid differentiation primary response 88 0.483224
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 0.481705
NR1H3 nuclear receptor subfamily 1, group H, member 3 0.477151
SPRR1B small proline-rich protein 1B 0.473361
STAB2 stabilin 2 0.457487
ILVBL ilvB (bacterial acetolactate synthase)-like 0.452585
SCARB2 scavenger receptor class B, member 2 0.449947
AREG amphiregulin 0.436778
CD36 CD36 molecule (thrombospondin receptor) 0.434524
CXCL10 chemokine (C-X-C motif) ligand 10 0.428516
TLR2 toll-like receptor 2 0.425514
FN1 fibronectin 1 0.41465
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.41465
GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 0.401199
CD200 CD200 molecule 0.400453
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) 0.396353
SCARB1 scavenger receptor class B, member 1 0.393746
SACK1H scaffolding CK1 anchoring protein H 0.393001
KRT10 keratin 10, type I 0.390397
S100A8 S100 calcium binding protein A8 0.388166
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.385565
KRT1 keratin 1, type II 0.379626
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.379626
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.374809
SLC39A6 solute carrier family 39 (zinc transporter), member 6 0.369997
XDH xanthine dehydrogenase 0.366301
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 0.363716
AQP3 aquaporin 3 (Gill blood group) 0.362978
CD40LG CD40 ligand 0.361133
FFAR4 free fatty acid receptor 4 0.357814
DKK4 dickkopf WNT signaling pathway inhibitor 4 0.355604
KDM6B lysine (K)-specific demethylase 6B 0.354868
CCL7 chemokine (C-C motif) ligand 7 0.351555
TGM3 transglutaminase 3 0.349349
TANK TRAF family member-associated NFKB activator 0.348246
FAM167A family with sequence similarity 167, member A 0.346042
RPLP0 ribosomal protein, large, P0 0.342372
RANBP2 RAN binding protein 2 0.338341
IL1R1 interleukin 1 receptor, type I 0.336144
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.334315
LCN1 lipocalin 1 0.327375
LDLR low density lipoprotein receptor 0.32701
TOLLIP toll interacting protein 0.324823
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.324094
ARG1 arginase 1 0.320817
SLCO1C1 solute carrier organic anion transporter family, member 1C1 0.318272
IL17C interleukin 17C 0.310652
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.308118
HLA-C major histocompatibility complex, class I, C 0.305948
CCL13 chemokine (C-C motif) ligand 13 0.305226
HDAC11 histone deacetylase 11 0.304142
TWIST2 twist family bHLH transcription factor 2 0.304142
GLDC glycine dehydrogenase (decarboxylating) 0.304142
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.30342
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.302337
E2F6 E2F transcription factor 6 0.300894
ICAM3 intercellular adhesion molecule 3 0.298371
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.296931
ICA1 islet cell autoantigen 1, 69kDa 0.296931
IL10 interleukin 10 0.296571
KRT12 keratin 12, type I 0.296211
ADSS adenylosuccinate synthase 0.296211
KRT14 keratin 14, type I 0.292975
TLR1 toll-like receptor 1 0.292616
UCN urocortin 0.292257
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.290821
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 0.290821
ADCY9 adenylate cyclase 9 0.283655
IRF5 interferon regulatory factor 5 0.28294
MAPK8 mitogen-activated protein kinase 8 0.28294
FABP7 fatty acid binding protein 7, brain 0.281153
GAS1 growth arrest-specific 1 0.279011
SLURP1 secreted LY6/PLAUR domain containing 1 0.273308
BANK1 B-cell scaffold protein with ankyrin repeats 1 0.270464
CPVL carboxypeptidase, vitellogenic-like 0.270108
CD209 CD209 molecule 0.269753
CORO1A coronin, actin binding protein, 1A 0.269043
CCL20 chemokine (C-C motif) ligand 20 0.266558
SHB Src homology 2 domain containing adaptor protein B 0.263368
TTR transthyretin 0.261952
PNMA1 paraneoplastic Ma antigen 1 0.25983
CARD8 caspase recruitment domain family, member 8 0.257711
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.257005
IRF3 interferon regulatory factor 3 0.252774
PDCD1LG2 programmed cell death 1 ligand 2 0.250311
IRAK3 interleukin-1 receptor-associated kinase 3 0.24996
MAPK14 mitogen-activated protein kinase 14 0.241546
TBX2 T-box 2 0.240847
MMP8 matrix metallopeptidase 8 0.237009
AIRE autoimmune regulator 0.232836
RNASEH2A ribonuclease H2, subunit A 0.231795
SSB Sjogren syndrome antigen B (autoantigen La) 0.225917
CRYZ crystallin, zeta (quinone reductase) 0.225229
SIGLEC10 sialic acid binding Ig-like lectin 10 0.22145
JUNB jun B proto-oncogene 0.217352
AARS alanyl-tRNA synthetase 0.217012
SALL1 spalt-like transcription factor 1 0.210925
IFNL1 interferon, lambda 1 0.209583
CD68 CD68 molecule 0.209248
ANG angiogenin, ribonuclease, RNase A family, 5 0.208914
NELFCD negative elongation factor complex member C/D 0.208579
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.208245
MMP13 matrix metallopeptidase 13 0.207912
CCL22 chemokine (C-C motif) ligand 22 0.207578
TLR9 toll-like receptor 9 0.204593
BCAN brevican 0.204593
MMP2 matrix metallopeptidase 2 0.203604
LY75 lymphocyte antigen 75 0.198386
PLK2 polo-like kinase 2 0.196139
FADD Fas (TNFRSF6)-associated via death domain 0.196139
TSLP thymic stromal lymphopoietin 0.191719
NPTXR neuronal pentraxin receptor 0.191408
C3AR1 complement component 3a receptor 1 0.187415
IQGAP1 IQ motif containing GTPase activating protein 1 0.180084
TNIP1 TNFAIP3 interacting protein 1 0.179239
PRKD1 protein kinase D1 0.17896
CCL27 chemokine (C-C motif) ligand 27 0.17896
MIRLET7B microRNA let-7b 0.174354
GLUL glutamate-ammonia ligase 0.174093
CTGF connective tissue growth factor 0.172291
CRHR2 corticotropin releasing hormone receptor 2 0.168381
PNP purine nucleoside phosphorylase 0.167682
CCL4 chemokine (C-C motif) ligand 4 0.166768
MT3 metallothionein 3 0.166095
IGFBP7 insulin-like growth factor binding protein 7 0.165655
MRI1 methylthioribose-1-phosphate isomerase 1 0.165435
GPBAR1 G protein-coupled bile acid receptor 1 0.165435
POU5F1B POU class 5 homeobox 1B 0.164571
ALB albumin 0.162908
ARPP21 cAMP-regulated phosphoprotein, 21kDa 0.161716
KRT15 keratin 15, type I 0.160574
NRTN neurturin 0.160574
TIMP1 TIMP metallopeptidase inhibitor 1 0.160574
LGALS9 lectin, galactoside-binding, soluble, 9 0.160387
SCAI suppressor of cancer cell invasion 0.160387
BOC BOC cell adhesion associated, oncogene regulated 0.15948
HBEGF heparin-binding EGF-like growth factor 0.159124