ketanserin-4995 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the ketanserin-4995 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ADAP2 ArfGAP with dual PH domains 2
ADD2 adducin 2 (beta)
ADGB androglobin
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ALDOB aldolase B, fructose-bisphosphate
ANKLE2 ankyrin repeat and LEM domain containing 2
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
B9D1 B9 protein domain 1
BGN biglycan
BIN1 bridging integrator 1
C14ORF105 chromosome 14 open reading frame 105
CCDC57 coiled-coil domain containing 57
CCL22 chemokine (C-C motif) ligand 22
CDC14B cell division cycle 14B
CHN2 chimerin 2
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
CLCN7 chloride channel, voltage-sensitive 7
CNTN1 contactin 1
CPED1 cadherin-like and PC-esterase domain containing 1
CSF1 colony stimulating factor 1 (macrophage)
CSN3 casein kappa
DRD1 dopamine receptor D1
EDN1 endothelin 1
ERN1 endoplasmic reticulum to nucleus signaling 1
FAM182B family with sequence similarity 182, member B
FFAR2 free fatty acid receptor 2
FHL1 four and a half LIM domains 1
FOXN3 forkhead box N3
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GLRX3 glutaredoxin 3
GLS glutaminase
GPER1 G protein-coupled estrogen receptor 1
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPM6B glycoprotein M6B
GPR15 G protein-coupled receptor 15
GRK4 G protein-coupled receptor kinase 4
GTPBP1 GTP binding protein 1
GYG2 glycogenin 2
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-DOA major histocompatibility complex, class II, DO alpha
IFNA14 interferon, alpha 14
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRF4 interferon regulatory factor 4
KCNK5 potassium channel, two pore domain subfamily K, member 5
KCTD7 potassium channel tetramerization domain containing 7
KIAA0509 uncharacterized LOC57242
LARP6 La ribonucleoprotein domain family, member 6
MARK4 MAP/microtubule affinity-regulating kinase 4
MID1 midline 1
MMP3 matrix metallopeptidase 3
MRPL41 mitochondrial ribosomal protein L41
MUC3A mucin 3A, cell surface associated
MVB12B multivesicular body subunit 12B
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NEB nebulin
OLFM1 olfactomedin 1
OR2H2 olfactory receptor, family 2, subfamily H, member 2
ORAI2 ORAI calcium release-activated calcium modulator 2
PARD3 par-3 family cell polarity regulator
PDE8B phosphodiesterase 8B
PHF8 PHD finger protein 8
PHOX2B paired-like homeobox 2b
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRELP proline/arginine-rich end leucine-rich repeat protein
PRO2964 uncharacterized protein PRO2964
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RGS10 regulator of G-protein signaling 10
S100A8 S100 calcium binding protein A8
SASH3 SAM and SH3 domain containing 3
SCAPER S-phase cyclin A-associated protein in the ER
SECTM1 secreted and transmembrane 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SGCE sarcoglycan, epsilon
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SMIM14 small integral membrane protein 14
SOCS7 suppressor of cytokine signaling 7
SORBS3 sorbin and SH3 domain containing 3
SPAG6 sperm associated antigen 6
SPAG8 sperm associated antigen 8
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SPINK4 serine peptidase inhibitor, Kazal type 4
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
TLDC1 TBC/LysM-associated domain containing 1
TLR2 toll-like receptor 2
TRA T cell receptor alpha locus
TRIM10 tripartite motif containing 10
TTC9 tetratricopeptide repeat domain 9
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
WDTC1 WD and tetratricopeptide repeats 1
WFDC2 WAP four-disulfide core domain 2
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZC3H7B zinc finger CCCH-type containing 7B
ZFP36L1 ZFP36 ring finger protein-like 1
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF444 zinc finger protein 444
ZNF493 zinc finger protein 493

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ATG9A autophagy related 9A
BABAM1 BRISC and BRCA1 A complex member 1
BSG basigin (Ok blood group)
CBR4 carbonyl reductase 4
CCDC25 coiled-coil domain containing 25
CEP170B centrosomal protein 170B
CFAP44 cilia and flagella associated protein 44
CHEK2 checkpoint kinase 2
CHKB choline kinase beta
CIDEC cell death-inducing DFFA-like effector c
CLCN5 chloride channel, voltage-sensitive 5
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CORO1A coronin, actin binding protein, 1A
CRELD1 cysteine-rich with EGF-like domains 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DEAF1 DEAF1 transcription factor
DSCAM Down syndrome cell adhesion molecule
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ELMO3 engulfment and cell motility 3
FRS2 fibroblast growth factor receptor substrate 2
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GALE UDP-galactose-4-epimerase
GALK1 galactokinase 1
GAN gigaxonin
GSTM2 glutathione S-transferase mu 2 (muscle)
GTF2I general transcription factor IIi
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HIST1H1E histone cluster 1, H1e
HIST1H2AJ histone cluster 1, H2aj
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMHA1 histocompatibility (minor) HA-1
HOOK1 hook microtubule-tethering protein 1
IDI2-AS1 IDI2 antisense RNA 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFNAR1 interferon (alpha, beta and omega) receptor 1
IPO8 importin 8
LMBR1L limb development membrane protein 1-like
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRRC20 leucine rich repeat containing 20
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MDM4 MDM4, p53 regulator
MED18 mediator complex subunit 18
METTL2B methyltransferase like 2B
MFSD12 major facilitator superfamily domain containing 12
MOSPD3 motile sperm domain containing 3
MPST mercaptopyruvate sulfurtransferase
MYO1E myosin IE
NME5 NME/NM23 family member 5
NPM3 nucleophosmin/nucleoplasmin 3
NT5C 5', 3'-nucleotidase, cytosolic
NT5E 5'-nucleotidase, ecto (CD73)
ODF2 outer dense fiber of sperm tails 2
OSMR oncostatin M receptor
PCDHB3 protocadherin beta 3
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRKX protein kinase, X-linked
PRMT7 protein arginine methyltransferase 7
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
QSER1 glutamine and serine rich 1
QTRT1 queuine tRNA-ribosyltransferase 1
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB3A RAB3A, member RAS oncogene family
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
ROM1 retinal outer segment membrane protein 1
RRP1 ribosomal RNA processing 1
SAV1 salvador family WW domain containing protein 1
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SMG9 SMG9 nonsense mediated mRNA decay factor
SPRYD7 SPRY domain containing 7
STX1A syntaxin 1A (brain)
SYTL2 synaptotagmin-like 2
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCTN1 tectonic family member 1
TM6SF1 transmembrane 6 superfamily member 1
TMC7 transmembrane channel-like 7
TRABD TraB domain containing
VGF VGF nerve growth factor inducible
XK X-linked Kx blood group
ZBTB48 zinc finger and BTB domain containing 48
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF227 zinc finger protein 227
ZNF276 zinc finger protein 276
ZNF551 zinc finger protein 551
ZNF586 zinc finger protein 586
ZNF639 zinc finger protein 639
ZNF675 zinc finger protein 675
ZNF804A zinc finger protein 804A