ketone body biosynthetic process Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA. (Gene Ontology, GO_0046951)
External Link http://amigo.geneontology.org/amigo/term/GO:0046951
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Genes

5 genes participating in the ketone body biosynthetic process biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
AACS acetoacetyl-CoA synthetase
ACSS3 acyl-CoA synthetase short-chain family member 3
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)