ketoprofen-2316 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the ketoprofen-2316 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAM12 ADAM metallopeptidase domain 12
AIRE autoimmune regulator
ANKH ANKH inorganic pyrophosphate transport regulator
ARC activity-regulated cytoskeleton-associated protein
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ASB1 ankyrin repeat and SOCS box containing 1
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C14ORF79 chromosome 14 open reading frame 79
C1QB complement component 1, q subcomponent, B chain
C3AR1 complement component 3a receptor 1
C8ORF44 chromosome 8 open reading frame 44
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CD3D CD3d molecule, delta (CD3-TCR complex)
CD8A CD8a molecule
CFHR4 complement factor H-related 4
CFLAR CASP8 and FADD-like apoptosis regulator
CHN2 chimerin 2
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLEC1A C-type lectin domain family 1, member A
CLGN calmegin
CYBB cytochrome b-245, beta polypeptide
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DOCK5 dedicator of cytokinesis 5
DSC2 desmocollin 2
EHD2 EH-domain containing 2
EMID1 EMI domain containing 1
FCMR Fc fragment of IgM receptor
FGF6 fibroblast growth factor 6
FGFR1 fibroblast growth factor receptor 1
GGT1 gamma-glutamyltransferase 1
GLYAT glycine-N-acyltransferase
GM2A GM2 ganglioside activator
GMPR guanosine monophosphate reductase
GPR68 G protein-coupled receptor 68
GSTTP1 glutathione S-transferase theta pseudogene 1
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HCRP1 hepatocellular carcinoma-related HCRP1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HNF1B HNF1 homeobox B
INO80D INO80 complex subunit D
IRF2BP1 interferon regulatory factor 2 binding protein 1
KANK1 KN motif and ankyrin repeat domains 1
KLHL25 kelch-like family member 25
KLRD1 killer cell lectin-like receptor subfamily D, member 1
LIMD1 LIM domains containing 1
LOC100131532 uncharacterized LOC100131532
LOC440792 proline dehydrogenase (oxidase) 1 pseudogene
MAN1C1 mannosidase, alpha, class 1C, member 1
MAP2K5 mitogen-activated protein kinase kinase 5
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MCTP1 multiple C2 domains, transmembrane 1
MST1L macrophage stimulating 1-like
MTCP1 mature T-cell proliferation 1
NF1 neurofibromin 1
NIPAL3 NIPA-like domain containing 3
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NRG2 neuregulin 2
OPRK1 opioid receptor, kappa 1
PAX9 paired box 9
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PDGFB platelet-derived growth factor beta polypeptide
PKNOX2 PBX/knotted 1 homeobox 2
POU4F1 POU class 4 homeobox 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PQLC2 PQ loop repeat containing 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RND1 Rho family GTPase 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RRAGB Ras-related GTP binding B
SCRN3 secernin 3
SERGEF secretion regulating guanine nucleotide exchange factor
SH2D3A SH2 domain containing 3A
SIPA1L3 signal-induced proliferation-associated 1 like 3
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SPTB spectrin, beta, erythrocytic
TCF3 transcription factor 3
TCHH trichohyalin
TERT telomerase reverse transcriptase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TM4SF4 transmembrane 4 L six family member 4
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TRIM29 tripartite motif containing 29
TRIM3 tripartite motif containing 3
TSC22D4 TSC22 domain family, member 4
UHRF1BP1L UHRF1 binding protein 1-like
USP46 ubiquitin specific peptidase 46
VIPR1 vasoactive intestinal peptide receptor 1
VPS13B vacuolar protein sorting 13 homolog B (yeast)
ZBTB44 zinc finger and BTB domain containing 44
ZFP36L2 ZFP36 ring finger protein-like 2
ZFPL1 zinc finger protein-like 1
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
AUTS2 autism susceptibility candidate 2
BAHD1 bromo adjacent homology domain containing 1
BTF3P12 basic transcription factor 3 pseudogene 12
C11ORF63 chromosome 11 open reading frame 63
C14ORF93 chromosome 14 open reading frame 93
CA11 carbonic anhydrase XI
CAPN15 calpain 15
CCDC121 coiled-coil domain containing 121
CCDC68 coiled-coil domain containing 68
CCDC85C coiled-coil domain containing 85C
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDK18 cyclin-dependent kinase 18
CES3 carboxylesterase 3
CIDEC cell death-inducing DFFA-like effector c
CLCN6 chloride channel, voltage-sensitive 6
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DEAF1 DEAF1 transcription factor
DIXDC1 DIX domain containing 1
DMC1 DNA meiotic recombinase 1
DMTN dematin actin binding protein
DNAL4 dynein, axonemal, light chain 4
DUSP13 dual specificity phosphatase 13
DUSP2 dual specificity phosphatase 2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
DYSF dysferlin
EPHX2 epoxide hydrolase 2, cytoplasmic
ERCC5 excision repair cross-complementation group 5
ERN2 endoplasmic reticulum to nucleus signaling 2
ERO1L ERO1-like (S. cerevisiae)
ESRP2 epithelial splicing regulatory protein 2
EXO5 exonuclease 5
F2R coagulation factor II (thrombin) receptor
FAM188A family with sequence similarity 188, member A
FBXO2 F-box protein 2
FLT4 fms-related tyrosine kinase 4
GAN gigaxonin
GPR21 G protein-coupled receptor 21
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRB7 growth factor receptor-bound protein 7
GSTM5 glutathione S-transferase mu 5
HIST1H1D histone cluster 1, H1d
HIST1H4F histone cluster 1, H4f
HOXC8 homeobox C8
IDI2-AS1 IDI2 antisense RNA 1
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KEL Kell blood group, metallo-endopeptidase
LRP5L low density lipoprotein receptor-related protein 5-like
LY6D lymphocyte antigen 6 complex, locus D
MED15 mediator complex subunit 15
MEIS2 Meis homeobox 2
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MUC3A mucin 3A, cell surface associated
MYO1F myosin IF
NLRX1 NLR family member X1
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLEKHO2 pleckstrin homology domain containing, family O member 2
PRF1 perforin 1 (pore forming protein)
PTPRS protein tyrosine phosphatase, receptor type, S
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC12A9 solute carrier family 12, member 9
SLC16A6 solute carrier family 16, member 6
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC44A1 solute carrier family 44 (choline transporter), member 1
STAB2 stabilin 2
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TBC1D17 TBC1 domain family, member 17
TBKBP1 TBK1 binding protein 1
TBX19 T-box 19
TDRD1 tudor domain containing 1
TFF2 trefoil factor 2
TMEM53 transmembrane protein 53
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TOM1 target of myb1 (chicken)
TRAF2 TNF receptor-associated factor 2
TRIM21 tripartite motif containing 21
TRIM68 tripartite motif containing 68
TSPYL2 TSPY-like 2
UNC119 unc-119 homolog (C. elegans)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZFP30 ZFP30 zinc finger protein
ZMAT5 zinc finger, matrin-type 5
ZNF10 zinc finger protein 10
ZNF16 zinc finger protein 16
ZNF442 zinc finger protein 442
ZNF770 zinc finger protein 770