ketoprofen-2354 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the ketoprofen-2354 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
AMT aminomethyltransferase
AQP4 aquaporin 4
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
BIN1 bridging integrator 1
BMP7 bone morphogenetic protein 7
C6ORF47 chromosome 6 open reading frame 47
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CCDC106 coiled-coil domain containing 106
CCL23 chemokine (C-C motif) ligand 23
CDRT1 CMT1A duplicated region transcript 1
CFP complement factor properdin
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
CIZ1 CDKN1A interacting zinc finger protein 1
CLDN18 claudin 18
COMT catechol-O-methyltransferase
CRIP1 cysteine-rich protein 1 (intestinal)
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22
DOK3 docking protein 3
EFNA5 ephrin-A5
EFR3B EFR3 homolog B (S. cerevisiae)
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EXT1 exostosin glycosyltransferase 1
FER1L4 fer-1-like family member 4, pseudogene (functional)
FKBP8 FK506 binding protein 8, 38kDa
FKBP9 FK506 binding protein 9, 63 kDa
FXYD3 FXYD domain containing ion transport regulator 3
GJA4 gap junction protein, alpha 4, 37kDa
GLP1R glucagon-like peptide 1 receptor
HIST1H3E histone cluster 1, H3e
HN1L hematological and neurological expressed 1-like
HOMER3 homer scaffolding protein 3
HSF1 heat shock transcription factor 1
IAPP islet amyloid polypeptide
IDS iduronate 2-sulfatase
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL36RN interleukin 36 receptor antagonist
JAM3 junctional adhesion molecule 3
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
LAMP1 lysosomal-associated membrane protein 1
LHFP lipoma HMGIC fusion partner
LPAR4 lysophosphatidic acid receptor 4
LRP6 low density lipoprotein receptor-related protein 6
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MOB3B MOB kinase activator 3B
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MREG melanoregulin
MSL3 male-specific lethal 3 homolog (Drosophila)
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NCALD neurocalcin delta
NCDN neurochondrin
NCR2 natural cytotoxicity triggering receptor 2
NDE1 nudE neurodevelopment protein 1
NDNF neuron-derived neurotrophic factor
NEB nebulin
NUDCD3 NudC domain containing 3
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PCDH11X protocadherin 11 X-linked
PENK proenkephalin
PHC1 polyhomeotic homolog 1 (Drosophila)
PICALM phosphatidylinositol binding clathrin assembly protein
PKP1 plakophilin 1
PLIN2 perilipin 2
PLTP phospholipid transfer protein
PRKD2 protein kinase D2
PRSS53 protease, serine, 53
PSG1 pregnancy specific beta-1-glycoprotein 1
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RAB11B RAB11B, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
REST RE1-silencing transcription factor
RFPL3 ret finger protein-like 3
RTEL1 regulator of telomere elongation helicase 1
SETBP1 SET binding protein 1
SIDT2 SID1 transmembrane family, member 2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STOM stomatin
SYT11 synaptotagmin XI
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBPL TAP binding protein-like
TCP11L1 t-complex 11, testis-specific-like 1
TECPR2 tectonin beta-propeller repeat containing 2
TGM2 transglutaminase 2
THPO thrombopoietin
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast)
TMBIM1 transmembrane BAX inhibitor motif containing 1
TRAPPC9 trafficking protein particle complex 9
TSSK2 testis-specific serine kinase 2
TTC30A tetratricopeptide repeat domain 30A
UHRF1BP1L UHRF1 binding protein 1-like
USB1 U6 snRNA biogenesis 1
VGLL1 vestigial-like family member 1
WNT8B wingless-type MMTV integration site family, member 8B

decreased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ACAD10 acyl-CoA dehydrogenase family, member 10
ACVR2B activin A receptor, type IIB
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ARRB2 arrestin, beta 2
ATAD5 ATPase family, AAA domain containing 5
BOLA1 bolA family member 1
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C1ORF54 chromosome 1 open reading frame 54
C5ORF30 chromosome 5 open reading frame 30
CALCOCO1 calcium binding and coiled-coil domain 1
CDK3 cyclin-dependent kinase 3
CPTP ceramide-1-phosphate transfer protein
CSF1R colony stimulating factor 1 receptor
CSNK1G3 casein kinase 1, gamma 3
DBF4B DBF4 zinc finger B
DEPDC1 DEP domain containing 1
DHRS11 dehydrogenase/reductase (SDR family) member 11
DPY19L2P2 DPY19L2 pseudogene 2
DYM dymeclin
EFHC1 EF-hand domain (C-terminal) containing 1
EML4 echinoderm microtubule associated protein like 4
ERN2 endoplasmic reticulum to nucleus signaling 2
F3 coagulation factor III (thromboplastin, tissue factor)
FHIT fragile histidine triad
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
GTF2I general transcription factor IIi
HCK HCK proto-oncogene, Src family tyrosine kinase
HIST1H2AI histone cluster 1, H2ai
IL2RG interleukin 2 receptor, gamma
ITPKB inositol-trisphosphate 3-kinase B
KIF18A kinesin family member 18A
LOC729164 hCG1732469
LY6E lymphocyte antigen 6 complex, locus E
MAGEF1 melanoma antigen family F1
MANSC1 MANSC domain containing 1
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MICA MHC class I polypeptide-related sequence A
MLPH melanophilin
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
NOD1 nucleotide-binding oligomerization domain containing 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OTUD3 OTU deubiquitinase 3
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCYOX1 prenylcysteine oxidase 1
PEX26 peroxisomal biogenesis factor 26
PHYH phytanoyl-CoA 2-hydroxylase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PPDPF pancreatic progenitor cell differentiation and proliferation factor
RABAC1 Rab acceptor 1 (prenylated)
RHOC ras homolog family member C
RIN1 Ras and Rab interactor 1
RNF126P1 ring finger protein 126 pseudogene 1
RNF141 ring finger protein 141
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF2 ring finger protein 2
RPP38 ribonuclease P/MRP 38kDa subunit
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SKA1 spindle and kinetochore associated complex subunit 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC22A18 solute carrier family 22, member 18
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SMYD5 SMYD family member 5
SNRPN small nuclear ribonucleoprotein polypeptide N
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRD5A3 steroid 5 alpha-reductase 3
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
SSBP3 single stranded DNA binding protein 3
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYNJ2BP synaptojanin 2 binding protein
TBX19 T-box 19
TET3 tet methylcytosine dioxygenase 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TLR4 toll-like receptor 4
TMEM110 transmembrane protein 110
TMEM159 transmembrane protein 159
TMEM183A transmembrane protein 183A
TMEM212 transmembrane protein 212
TPK1 thiamin pyrophosphokinase 1
TRAPPC13 trafficking protein particle complex 13
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TSPAN13 tetraspanin 13
VASP vasodilator-stimulated phosphoprotein
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
XPC xeroderma pigmentosum, complementation group C
XYLT2 xylosyltransferase II
YEATS2 YEATS domain containing 2
ZBED1 zinc finger, BED-type containing 1
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF141 zinc finger protein 141
ZNF280D zinc finger protein 280D
ZNF32 zinc finger protein 32
ZNF552 zinc finger protein 552
ZNHIT2 zinc finger, HIT-type containing 2