ketoprofen-3626 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the ketoprofen-3626 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACO2 aconitase 2, mitochondrial
ACPP acid phosphatase, prostate
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20
ALDOB aldolase B, fructose-bisphosphate
ALPPL2 alkaline phosphatase, placental-like 2
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARID5A AT rich interactive domain 5A (MRF1-like)
ART1 ADP-ribosyltransferase 1
BAZ2A bromodomain adjacent to zinc finger domain, 2A
C10ORF95 chromosome 10 open reading frame 95
C1ORF54 chromosome 1 open reading frame 54
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CALML3 calmodulin-like 3
CCDC64 coiled-coil domain containing 64
CCL19 chemokine (C-C motif) ligand 19
CEP41 centrosomal protein 41kDa
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CLCF1 cardiotrophin-like cytokine factor 1
CSF1 colony stimulating factor 1 (macrophage)
CTIF CBP80/20-dependent translation initiation factor
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DLK1 delta-like 1 homolog (Drosophila)
DOCK9 dedicator of cytokinesis 9
EFR3B EFR3 homolog B (S. cerevisiae)
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EPX eosinophil peroxidase
EPYC epiphycan
FAM13A family with sequence similarity 13, member A
FER1L4 fer-1-like family member 4, pseudogene (functional)
FGA fibrinogen alpha chain
FLOT1 flotillin 1
FSHB follicle stimulating hormone, beta polypeptide
GPR18 G protein-coupled receptor 18
HIST1H3I histone cluster 1, H3i
HOXA10 homeobox A10
HSPB2 heat shock 27kDa protein 2
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
ICAM1 intercellular adhesion molecule 1
IL36R interleukin 36 receptor
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
IQCE IQ motif containing E
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
LGALS8 lectin, galactoside-binding, soluble, 8
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LMTK2 lemur tyrosine kinase 2
LOC100131532 uncharacterized LOC100131532
LPPR1 lipid phosphate phosphatase-related protein type 1
LRRC48 leucine rich repeat containing 48
LTC4S leukotriene C4 synthase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K5 mitogen-activated protein kinase kinase 5
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MKL1 megakaryoblastic leukemia (translocation) 1
MPPE1 metallophosphoesterase 1
MXRA8 matrix-remodelling associated 8
MYRF myelin regulatory factor
NDN necdin, melanoma antigen (MAGE) family member
NEU3 sialidase 3 (membrane sialidase)
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
ODAM odontogenic, ameloblast asssociated
OMD osteomodulin
OPCML opioid binding protein/cell adhesion molecule-like
PAOX polyamine oxidase (exo-N4-amino)
PARP3 poly (ADP-ribose) polymerase family, member 3
PARVA parvin, alpha
PCSK6 proprotein convertase subtilisin/kexin type 6
PDPN podoplanin
PIPOX pipecolic acid oxidase
PLD1 phospholipase D1, phosphatidylcholine-specific
POM121L9P POM121 transmembrane nucleoporin-like 9, pseudogene
POU3F4 POU class 3 homeobox 4
PPARA peroxisome proliferator-activated receptor alpha
PPP1R37 protein phosphatase 1, regulatory subunit 37
RAD52 RAD52 homolog (S. cerevisiae)
RAP1GAP RAP1 GTPase activating protein
RASSF4 Ras association (RalGDS/AF-6) domain family member 4
RECQL5 RecQ protein-like 5
RHEB Ras homolog enriched in brain
RNF17 ring finger protein 17
RPL35A ribosomal protein L35a
SIRT5 sirtuin 5
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SOX2 SRY (sex determining region Y)-box 2
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN3 transgelin 3
TCEAL2 transcription elongation factor A (SII)-like 2
TGM3 transglutaminase 3
THBS1 thrombospondin 1
TRIP6 thyroid hormone receptor interactor 6
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZFP64 ZFP64 zinc finger protein
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
APOLD1 apolipoprotein L domain containing 1
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ATAD5 ATPase family, AAA domain containing 5
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BAHCC1 BAH domain and coiled-coil containing 1
BCO1 beta-carotene oxygenase 1
C7ORF43 chromosome 7 open reading frame 43
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAPN15 calpain 15
CCDC71 coiled-coil domain containing 71
CD83 CD83 molecule
CDH10 cadherin 10, type 2 (T2-cadherin)
CEND1 cell cycle exit and neuronal differentiation 1
CFAP70 cilia and flagella associated protein 70
CLGN calmegin
CLSPN claspin
CNTN1 contactin 1
CRIP1 cysteine-rich protein 1 (intestinal)
CTRL chymotrypsin-like
CXADR coxsackie virus and adenovirus receptor
DAGLA diacylglycerol lipase, alpha
DEPDC5 DEP domain containing 5
DOK5 docking protein 5
EPHX2 epoxide hydrolase 2, cytoplasmic
ERN2 endoplasmic reticulum to nucleus signaling 2
FADS2 fatty acid desaturase 2
FAM212B family with sequence similarity 212, member B
FFAR2 free fatty acid receptor 2
FGD1 FYVE, RhoGEF and PH domain containing 1
GADD45G growth arrest and DNA-damage-inducible, gamma
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLDC glycine dehydrogenase (decarboxylating)
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GSTTP1 glutathione S-transferase theta pseudogene 1
GUSBP3 glucuronidase, beta pseudogene 3
HDAC7 histone deacetylase 7
HIST1H1D histone cluster 1, H1d
HOXC8 homeobox C8
IL12RB1 interleukin 12 receptor, beta 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KPNA5 karyopherin alpha 5 (importin alpha 6)
LAMP3 lysosomal-associated membrane protein 3
LYRM9 LYR motif containing 9
MAST3 microtubule associated serine/threonine kinase 3
MDM4 MDM4, p53 regulator
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NEURL1 neuralized E3 ubiquitin protein ligase 1
NLRX1 NLR family member X1
NPY4R neuropeptide Y receptor Y4
ONECUT1 one cut homeobox 1
ONECUT2 one cut homeobox 2
PACS1 phosphofurin acidic cluster sorting protein 1
PADI1 peptidyl arginine deiminase, type I
PCDHA5 protocadherin alpha 5
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PLA2G3 phospholipase A2, group III
PLCD1 phospholipase C, delta 1
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
POLL polymerase (DNA directed), lambda
POMT2 protein-O-mannosyltransferase 2
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RAB36 RAB36, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASL11B RAS-like, family 11, member B
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS2 regulator of G-protein signaling 2
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF208 ring finger protein 208
RNF43 ring finger protein 43
RPAP1 RNA polymerase II associated protein 1
RPL13P5 ribosomal protein L13 pseudogene 5
S100A2 S100 calcium binding protein A2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SKI SKI proto-oncogene
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SNTA1 syntrophin, alpha 1
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TARP TCR gamma alternate reading frame protein
TMEM104 transmembrane protein 104
TNRC6B trinucleotide repeat containing 6B
TUBA3C tubulin, alpha 3c
USB1 U6 snRNA biogenesis 1
VPS9D1 VPS9 domain containing 1
ZFHX4 zinc finger homeobox 4
ZNF276 zinc finger protein 276
ZNF721 zinc finger protein 721
ZNF747 zinc finger protein 747
ZSCAN2 zinc finger and SCAN domain containing 2