ketotifen-5842 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the ketotifen-5842 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTR5 ARP5 actin-related protein 5 homolog (yeast)
ACYP1 acylphosphatase 1, erythrocyte (common) type
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
AHI1 Abelson helper integration site 1
AKR1C1 aldo-keto reductase family 1, member C1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANK1 ankyrin 1, erythrocytic
BEND5 BEN domain containing 5
C19ORF60 chromosome 19 open reading frame 60
C9ORF156 chromosome 9 open reading frame 156
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CALHM2 calcium homeostasis modulator 2
CCDC93 coiled-coil domain containing 93
CCPG1 cell cycle progression 1
CES2 carboxylesterase 2
CFAP45 cilia and flagella associated protein 45
CFLAR CASP8 and FADD-like apoptosis regulator
CLU clusterin
CNOT8 CCR4-NOT transcription complex, subunit 8
CSPP1 centrosome and spindle pole associated protein 1
CTNND2 catenin (cadherin-associated protein), delta 2
CYTH1 cytohesin 1
DOCK5 dedicator of cytokinesis 5
DOCK9 dedicator of cytokinesis 9
EHBP1L1 EH domain binding protein 1-like 1
EPS8L1 EPS8-like 1
FAM50B family with sequence similarity 50, member B
FGF1 fibroblast growth factor 1 (acidic)
FGF5 fibroblast growth factor 5
FLI1 Fli-1 proto-oncogene, ETS transcription factor
GABARAPL1 GABA(A) receptor-associated protein like 1
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GNL1 guanine nucleotide binding protein-like 1
GRAMD4 GRAM domain containing 4
GTPBP4 GTP binding protein 4
HAUS6 HAUS augmin-like complex, subunit 6
HDAC5 histone deacetylase 5
IFI6 interferon, alpha-inducible protein 6
IKZF5 IKAROS family zinc finger 5 (Pegasus)
ISG20 interferon stimulated exonuclease gene 20kDa
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KIAA0753 KIAA0753
KIAA0754 KIAA0754
LRRC37A3 leucine rich repeat containing 37, member A3
LYPD3 LY6/PLAUR domain containing 3
MAGEA5 melanoma antigen family A5
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MEG3 maternally expressed 3 (non-protein coding)
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MTM1 myotubularin 1
MTUS1 microtubule associated tumor suppressor 1
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NID2 nidogen 2 (osteonidogen)
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1
PAOX polyamine oxidase (exo-N4-amino)
PDE4DIP phosphodiesterase 4D interacting protein
PDGFB platelet-derived growth factor beta polypeptide
PER3 period circadian clock 3
PEX10 peroxisomal biogenesis factor 10
PLSCR1 phospholipid scramblase 1
POLG polymerase (DNA directed), gamma
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTK2B protein tyrosine kinase 2 beta
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
RAB11B RAB11B, member RAS oncogene family
RB1CC1 RB1-inducible coiled-coil 1
RBBP9 retinoblastoma binding protein 9
RIBC2 RIB43A domain with coiled-coils 2
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
SCARB2 scavenger receptor class B, member 2
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC25A44 solute carrier family 25, member 44
SLC43A3 solute carrier family 43, member 3
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD7 SMAD family member 7
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SOX13 SRY (sex determining region Y)-box 13
SPIDR scaffolding protein involved in DNA repair
SPRYD7 SPRY domain containing 7
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
SUMO1 small ubiquitin-like modifier 1
TCP11L1 t-complex 11, testis-specific-like 1
TEX40 testis expressed 40
TFE3 transcription factor binding to IGHM enhancer 3
TLE2 transducin-like enhancer of split 2
TMCC1 transmembrane and coiled-coil domain family 1
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSKU tsukushi, small leucine rich proteoglycan
USF2 upstream transcription factor 2, c-fos interacting
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
ZBTB1 zinc finger and BTB domain containing 1
ZMYND11 zinc finger, MYND-type containing 11
ZNF324 zinc finger protein 324
ZNF358 zinc finger protein 358
ZNF484 zinc finger protein 484
ZNF702P zinc finger protein 702, pseudogene

decreased expression

Symbol Name
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AK5 adenylate kinase 5
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARID3B AT rich interactive domain 3B (BRIGHT-like)
BATF3 basic leucine zipper transcription factor, ATF-like 3
BBS7 Bardet-Biedl syndrome 7
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BOLA1 bolA family member 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTF3P12 basic transcription factor 3 pseudogene 12
C11ORF63 chromosome 11 open reading frame 63
C11ORF80 chromosome 11 open reading frame 80
C2ORF44 chromosome 2 open reading frame 44
CAMTA2 calmodulin binding transcription activator 2
CCDC176 coiled-coil domain containing 176
CCNA1 cyclin A1
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CENPO centromere protein O
CLDN15 claudin 15
CLEC16A C-type lectin domain family 16, member A
CNKSR1 connector enhancer of kinase suppressor of Ras 1
COBL cordon-bleu WH2 repeat protein
CTSO cathepsin O
CUEDC1 CUE domain containing 1
CUL9 cullin 9
CXCL3 chemokine (C-X-C motif) ligand 3
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DSPP dentin sialophosphoprotein
EN1 engrailed homeobox 1
EPPK1 epiplakin 1
ERF Ets2 repressor factor
FAM186A family with sequence similarity 186, member A
FAT4 FAT atypical cadherin 4
FGD1 FYVE, RhoGEF and PH domain containing 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GPATCH1 G patch domain containing 1
GPRASP1 G protein-coupled receptor associated sorting protein 1
HIST1H2AI histone cluster 1, H2ai
HIST1H2BF histone cluster 1, H2bf
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
INCENP inner centromere protein antigens 135/155kDa
IRF2 interferon regulatory factor 2
JUNB jun B proto-oncogene
KCTD7 potassium channel tetramerization domain containing 7
KIAA1462 KIAA1462
LZTR1 leucine-zipper-like transcription regulator 1
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAST3 microtubule associated serine/threonine kinase 3
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MPI mannose phosphate isomerase
NACA2 nascent polypeptide-associated complex alpha subunit 2
NCS1 neuronal calcium sensor 1
NFS1 NFS1 cysteine desulfurase
NHEJ1 nonhomologous end-joining factor 1
NPFFR1 neuropeptide FF receptor 1
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
P3H2 prolyl 3-hydroxylase 2
PADI1 peptidyl arginine deiminase, type I
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLEKHO2 pleckstrin homology domain containing, family O member 2
PRR14L proline rich 14-like
RAB3A RAB3A, member RAS oncogene family
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RIN1 Ras and Rab interactor 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF31 ring finger protein 31
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SAMD9 sterile alpha motif domain containing 9
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCAI suppressor of cancer cell invasion
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SETD8 SET domain containing (lysine methyltransferase) 8
SH2D4A SH2 domain containing 4A
SNIP1 Smad nuclear interacting protein 1
SPATA1 spermatogenesis associated 1
STAG3 stromal antigen 3
STEAP4 STEAP family member 4
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TKFC triokinase/FMN cyclase
TMEM62 transmembrane protein 62
TMSB15A thymosin beta 15a
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TNRC6B trinucleotide repeat containing 6B
TSPAN1 tetraspanin 1
TUBA3C tubulin, alpha 3c
UBQLN4 ubiquilin 4
USP27X ubiquitin specific peptidase 27, X-linked
VEZT vezatin, adherens junctions transmembrane protein
VSIG10 V-set and immunoglobulin domain containing 10
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF280D zinc finger protein 280D
ZNF446 zinc finger protein 446
ZNF528 zinc finger protein 528