klf5_18983969_embryonic_stem_cell_lof_mouse_gpl1261_gds3509 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations
Category transcriptomics
Type transcription factor perturbation
Description transcription factor perturbation identified as [TF gene symbol]_[publication PMID]_[cell or tissue]_[perturbation]_[organism]_[GEO platform]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GDS3509
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Genes

302 genes differentially expressed following the klf5_18983969_embryonic_stem_cell_lof_mouse_gpl1261_gds3509 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

increased expression

Symbol Name Standardized Value
EFHC2 EF-hand domain (C-terminal) containing 2 0.214091
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.213536
TGM6 transglutaminase 6 0.213494
HOXC8 homeobox C8 0.21272
PRRX1 paired related homeobox 1 0.212383
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G 0.212285
CD53 CD53 molecule 0.210646
OR11H4 olfactory receptor, family 11, subfamily H, member 4 0.210111
TMEM214 transmembrane protein 214 0.206644
ERAP1 endoplasmic reticulum aminopeptidase 1 0.206644
AKR1C3 aldo-keto reductase family 1, member C3 0.202261
FGF2 fibroblast growth factor 2 (basic) 0.199456
SYT2 synaptotagmin II 0.199161
SH3KBP1 SH3-domain kinase binding protein 1 0.196561
LY86 lymphocyte antigen 86 0.192188
NCMAP noncompact myelin associated protein 0.189028
PCDH19 protocadherin 19 0.188969
MIA2 melanoma inhibitory activity 2 0.181985
GREM2 gremlin 2, DAN family BMP antagonist 0.180964
KLHL15 kelch-like family member 15 0.180934
GALC galactosylceramidase 0.173228
CAPN12 calpain 12 0.171892
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.171722
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 0.171366
TBX15 T-box 15 0.170314
HIST1H4H histone cluster 1, H4h 0.164186
ORAI2 ORAI calcium release-activated calcium modulator 2 0.162392
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.15762
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 0.156785
OR51B2 olfactory receptor, family 51, subfamily B, member 2 (gene/pseudogene) 0.156502
SPATA21 spermatogenesis associated 21 0.155733
C2ORF40 chromosome 2 open reading frame 40 0.150082
POU3F3 POU class 3 homeobox 3 0.149766
EREG epiregulin 0.14945
ACHE acetylcholinesterase (Yt blood group) 0.148063
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 0.147355
SCT secretin 0.145651
THEM4 thioesterase superfamily member 4 0.145477
ADD2 adducin 2 (beta) 0.144988
CIB3 calcium and integrin binding family member 3 0.141347
CPLX2 complexin 2 0.140858
TIMP2 TIMP metallopeptidase inhibitor 2 0.134326
PCDH7 protocadherin 7 0.130682
NNMT nicotinamide N-methyltransferase 0.130367
THBD thrombomodulin 0.129489
SORBS1 sorbin and SH3 domain containing 1 0.128971
CA4 carbonic anhydrase IV 0.126123
CCDC9 coiled-coil domain containing 9 0.125716
BGN biglycan 0.124186
AMBP alpha-1-microglobulin/bikunin precursor 0.123282
ADI1 acireductone dioxygenase 1 0.12325
ACTG2 actin, gamma 2, smooth muscle, enteric 0.121519
SP110 SP110 nuclear body protein 0.121286
HOXB6 homeobox B6 0.120975
CCDC88B coiled-coil domain containing 88B 0.120773
C11ORF88 chromosome 11 open reading frame 88 0.120586
CYB5D2 cytochrome b5 domain containing 2 0.120416
SNORD123 small nucleolar RNA, C/D box 123 0.119873
MAGEA4 melanoma antigen family A4 0.118007
RRAD Ras-related associated with diabetes 0.11502
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 0.113692
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.112707
IFI27L1 interferon, alpha-inducible protein 27-like 1 0.112292
SP100 SP100 nuclear antigen 0.110614
LCE1F late cornified envelope 1F 0.109464
IDUA iduronidase, alpha-L- 0.107703
CLINT1 clathrin interactor 1 0.106374
LYZL4 lysozyme-like 4 0.105764
RFTN2 raftlin family member 2 0.104851
GPR149 G protein-coupled receptor 149 0.103604
MYL12B myosin, light chain 12B, regulatory 0.101119
LOX lysyl oxidase 0.097608
ALCAM activated leukocyte cell adhesion molecule 0.097383
DCN decorin 0.088974
SLC35A5 solute carrier family 35, member A5 0.08834
ACTN2 actinin, alpha 2 0.082896
RAB8A RAB8A, member RAS oncogene family 0.082127
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.081923
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 0.081836
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.081286
STK25 serine/threonine kinase 25 0.08049
VCAM1 vascular cell adhesion molecule 1 0.079465
CCDC109B coiled-coil domain containing 109B 0.076465
TWIST2 twist family bHLH transcription factor 2 0.075708
INMT indolethylamine N-methyltransferase 0.073319
ZWINT ZW10 interacting kinetochore protein 0.071678
HAS2 hyaluronan synthase 2 0.068698
TIMP3 TIMP metallopeptidase inhibitor 3 0.064597
SLIT3 slit homolog 3 (Drosophila) 0.063673
COL1A2 collagen, type I, alpha 2 0.062022
HNRNPL heterogeneous nuclear ribonucleoprotein L 0.060628
GREM1 gremlin 1, DAN family BMP antagonist 0.058248
MAB21L1 mab-21-like 1 (C. elegans) 0.057653
IFI44L interferon-induced protein 44-like 0.055001
FAM149A family with sequence similarity 149, member A 0.049172
SLC5A12 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12 0.046941
CCDC80 coiled-coil domain containing 80 0.046306
ERICH6 glutamate-rich 6 0.046162
SNTG1 syntrophin, gamma 1 0.042442
IQCF5 IQ motif containing F5 0.040803
INHBA inhibin, beta A 0.040773
SDPR serum deprivation response 0.040125
MEG3 maternally expressed 3 (non-protein coding) 0.038079
KIAA0040 KIAA0040 0.037911
NRP1 neuropilin 1 0.036769
RASSF4 Ras association (RalGDS/AF-6) domain family member 4 0.035743
AGR2 anterior gradient 2 0.033979
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 0.033512
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 0.029165
FXYD5 FXYD domain containing ion transport regulator 5 0.027526
USP47 ubiquitin specific peptidase 47 0.026008
AHRR aryl-hydrocarbon receptor repressor 0.024286
NES nestin 0.022607
DCLK1 doublecortin-like kinase 1 0.022372
FST follistatin 0.021535
GHR growth hormone receptor 0.021276
PRKCDBP protein kinase C, delta binding protein 0.016366
PDZD9 PDZ domain containing 9 0.009714
SMYD1 SET and MYND domain containing 1 0.008979
SET SET nuclear proto-oncogene 0.005555
LRRK2 leucine-rich repeat kinase 2 0.005242
PSD pleckstrin and Sec7 domain containing 0.003808
VAMP5 vesicle-associated membrane protein 5 0.002976
GPR176 G protein-coupled receptor 176 0.002074
S1PR1 sphingosine-1-phosphate receptor 1 6.66E-4

decreased expression

Symbol Name Standardized Value
SIRPB1 signal-regulatory protein beta 1 -1.28483
KIAA1024 KIAA1024 -1.27558
MPTX1 mucosal pentraxin 1 (pseudogene) -1.23415
RASA4 RAS p21 protein activator 4 -1.23018
SYNJ2 synaptojanin 2 -1.21806
SPTSSB serine palmitoyltransferase, small subunit B -1.21362
ZSCAN5B zinc finger and SCAN domain containing 5B -1.20724
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10 -1.1777
SEZ6L seizure related 6 homolog (mouse)-like -1.14211
ASXL2 additional sex combs like transcriptional regulator 2 -1.13189
MYOG myogenin (myogenic factor 4) -1.12891
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 -1.12794
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 -1.11978
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -1.09501
KLHL5 kelch-like family member 5 -1.09357
PARP6 poly (ADP-ribose) polymerase family, member 6 -1.08337
ARHGAP10 Rho GTPase activating protein 10 -1.06706
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 -1.06409
CITED4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 -1.06381
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma -1.05897
KCNK13 potassium channel, two pore domain subfamily K, member 13 -1.05557
COL4A4 collagen, type IV, alpha 4 -1.05481
BTBD7 BTB (POZ) domain containing 7 -1.05046
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 -1.04768
ADAT3 adenosine deaminase, tRNA-specific 3 -1.04568
SH3TC1 SH3 domain and tetratricopeptide repeats 1 -1.04313
CCBL1 cysteine conjugate-beta lyase, cytoplasmic -1.03856
TIA1 TIA1 cytotoxic granule-associated RNA binding protein -1.01027
C2CD5 C2 calcium-dependent domain containing 5 -0.970423
TMPRSS11E transmembrane protease, serine 11E -0.96513
RNFT2 ring finger protein, transmembrane 2 -0.962072
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 -0.936688
GBA2 glucosidase, beta (bile acid) 2 -0.924931
SP4 Sp4 transcription factor -0.913612
SLC12A8 solute carrier family 12, member 8 -0.89066
CDK13 cyclin-dependent kinase 13 -0.874913
TMEM232 transmembrane protein 232 -0.872408
NCR1 natural cytotoxicity triggering receptor 1 -0.849146
GIMAP6 GTPase, IMAP family member 6 -0.847528
RNF151 ring finger protein 151 -0.829432
SLA Src-like-adaptor -0.817236
FGGY FGGY carbohydrate kinase domain containing -0.815262
ACY3 aminoacylase 3 -0.793904
OPTN optineurin -0.776512
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 -0.765259
GMEB1 glucocorticoid modulatory element binding protein 1 -0.76517
TLN2 talin 2 -0.762776
GPR15 G protein-coupled receptor 15 -0.762024
CAGE1 cancer antigen 1 -0.757453
SLC45A1 solute carrier family 45, member 1 -0.757234
UBQLN2 ubiquilin 2 -0.755315
ITSN1 intersectin 1 (SH3 domain protein) -0.742023
ZNF443 zinc finger protein 443 -0.737986
SOGA1 suppressor of glucose, autophagy associated 1 -0.737819
ARHGAP9 Rho GTPase activating protein 9 -0.736774
MYO1H myosin IH -0.732001
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.728999
ACSL1 acyl-CoA synthetase long-chain family member 1 -0.715488
CXORF65 chromosome X open reading frame 65 -0.713587
OBP2A odorant binding protein 2A -0.708953
CEP128 centrosomal protein 128kDa -0.707161
MUC4 mucin 4, cell surface associated -0.694495
HTRA3 HtrA serine peptidase 3 -0.692766
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.691831
PGAP2 post-GPI attachment to proteins 2 -0.688481
PRTN3 proteinase 3 -0.687963
MICALL2 MICAL-like 2 -0.685857
NRXN3 neurexin 3 -0.683799
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -0.678421
GULOP gulonolactone (L-) oxidase, pseudogene -0.675541
CDYL2 chromodomain protein, Y-like 2 -0.67347
HFE2 hemochromatosis type 2 (juvenile) -0.668693
PCDHB12 protocadherin beta 12 -0.665053
SPRED1 sprouty-related, EVH1 domain containing 1 -0.657345
POC1B POC1 centriolar protein B -0.653968
EPHB2 EPH receptor B2 -0.652476
OPRM1 opioid receptor, mu 1 -0.649208
ATOH7 atonal homolog 7 (Drosophila) -0.643434
ZSCAN20 zinc finger and SCAN domain containing 20 -0.636897
JRK Jrk homolog (mouse) -0.623922
CD3D CD3d molecule, delta (CD3-TCR complex) -0.613098
MYH6 myosin, heavy chain 6, cardiac muscle, alpha -0.598387
CHRM4 cholinergic receptor, muscarinic 4 -0.595317
WNT10A wingless-type MMTV integration site family, member 10A -0.593268
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 -0.588721
SEPT1 septin 1 -0.583347
XRN2 5'-3' exoribonuclease 2 -0.580557
GPRC6A G protein-coupled receptor, class C, group 6, member A -0.577025
AMDHD1 amidohydrolase domain containing 1 -0.573834
MAP1A microtubule-associated protein 1A -0.570841
ZBTB3 zinc finger and BTB domain containing 3 -0.570098
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 -0.567554
DEFB1 defensin, beta 1 -0.565528
FAM46B family with sequence similarity 46, member B -0.558127
APC2 adenomatosis polyposis coli 2 -0.557585
DGKG diacylglycerol kinase, gamma 90kDa -0.550206
HAGHL hydroxyacylglutathione hydrolase-like -0.545711
SEH1L SEH1-like (S. cerevisiae) -0.543248
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 -0.533323
TRIM17 tripartite motif containing 17 -0.529718
CDH10 cadherin 10, type 2 (T2-cadherin) -0.52914
LRRC4C leucine rich repeat containing 4C -0.522094
SUFU suppressor of fused homolog (Drosophila) -0.507162
ANK2 ankyrin 2, neuronal -0.503359
CD180 CD180 molecule -0.497907
ACSL6 acyl-CoA synthetase long-chain family member 6 -0.497907
CCDC151 coiled-coil domain containing 151 -0.49107
MID1 midline 1 -0.482639
MNT MAX network transcriptional repressor -0.481566
TXNL1 thioredoxin-like 1 -0.481491
RPS23 ribosomal protein S23 -0.479363
SSU72 SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) -0.471598
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 -0.471115
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled -0.466558
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 -0.462398
APOB apolipoprotein B -0.459055
ENAM enamelin -0.457488
FOXF2 forkhead box F2 -0.4562
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 -0.451857
PGA5 pepsinogen 5, group I (pepsinogen A) -0.451569
PLXNA3 plexin A3 -0.451195
TTC21A tetratricopeptide repeat domain 21A -0.449644
DCC DCC netrin 1 receptor -0.447273
PCTP phosphatidylcholine transfer protein -0.446939
TADA1 transcriptional adaptor 1 -0.442599
NCAN neurocan -0.441792
PRAP1 proline-rich acidic protein 1 -0.437382
TFAP2D transcription factor AP-2 delta (activating enhancer binding protein 2 delta) -0.436776
ANAPC16 anaphase promoting complex subunit 16 -0.434668
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.429802
IDNK idnK, gluconokinase homolog (E. coli) -0.063608
SDK2 sidekick cell adhesion molecule 2 -0.062738
TMEM106B transmembrane protein 106B -0.062413
MEGF6 multiple EGF-like-domains 6 -0.060486
AGA aspartylglucosaminidase -0.057836
NXF3 nuclear RNA export factor 3 -0.05656
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.054274
MSRB3 methionine sulfoxide reductase B3 -0.054023
PDE4B phosphodiesterase 4B, cAMP-specific -0.050865
HOXD9 homeobox D9 -0.048269
CHIA chitinase, acidic -0.047223
OTC ornithine carbamoyltransferase -0.046349
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -0.046246
MGP matrix Gla protein -0.045226
S1PR3 sphingosine-1-phosphate receptor 3 -0.044922
OAF OAF homolog (Drosophila) -0.04387
ZNF25 zinc finger protein 25 -0.043581
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 -0.042901
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 -0.040255
FAM114A1 family with sequence similarity 114, member A1 -0.038188
PDLIM4 PDZ and LIM domain 4 -0.032728
UMODL1 uromodulin-like 1 -0.032358
TFPI2 tissue factor pathway inhibitor 2 -0.032206
NMRK1 nicotinamide riboside kinase 1 -0.027217
LRRIQ4 leucine-rich repeats and IQ motif containing 4 -0.026533
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 -0.026158
NPAS1 neuronal PAS domain protein 1 -0.025694
MBOAT7 membrane bound O-acyltransferase domain containing 7 -0.024959
COL12A1 collagen, type XII, alpha 1 -0.024514
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.021522
VASN vasorin -0.021097
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.020355
POLD4 polymerase (DNA-directed), delta 4, accessory subunit -0.018032
KIAA1407 KIAA1407 -0.015422
CD44 CD44 molecule (Indian blood group) -0.015057
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) -0.014327
P4HA3 prolyl 4-hydroxylase, alpha polypeptide III -0.014077
MXRA7 matrix-remodelling associated 7 -0.01076
FOXS1 forkhead box S1 -0.010667
ZNF503 zinc finger protein 503 -0.007279
TSPO translocator protein (18kDa) -0.006794
SRCIN1 SRC kinase signaling inhibitor 1 -0.006447
MPDZ multiple PDZ domain protein -0.005036
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa -0.004223
TBK1 TANK-binding kinase 1 -9.69E-4
RGS16 regulator of G-protein signaling 16 -5.74E-4
ACSS2 acyl-CoA synthetase short-chain family member 2 -1.53E-4
Funding