knee Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description 1: A joint in the middle part of the human leg that is the articulation between the femur, tibia, and patella; also: the part of the leg that includes this joint. 2a: The joint in the hind leg of a four-footed vertebrate that corresponds to the human knee. 2b: The carpal joint of the foreleg of a four-footed vertebrate. 2c: The tarsal joint of a bird. 2d: The joint between the femur and tibia of an insect. (BRENDA Tissue and Enzyme Source Ontology, BTO_0003595)
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Genes

119 genes co-occuring with the biological term knee in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACAN aggrecan
ACE angiotensin I converting enzyme
ACTN3 actinin, alpha 3 (gene/pseudogene)
ADAM12 ADAM metallopeptidase domain 12
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
AGER advanced glycosylation end product-specific receptor
AHSG alpha-2-HS-glycoprotein
AKT1 v-akt murine thymoma viral oncogene homolog 1
APOA1 apolipoprotein A-I
APOB apolipoprotein B
ASPN asporin
BAG6 BCL2-associated athanogene 6
BDNF brain-derived neurotrophic factor
BGLAP bone gamma-carboxyglutamate (gla) protein
BMP7 bone morphogenetic protein 7
BTNL2 butyrophilin-like 2
CALCA calcitonin-related polypeptide alpha
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCL2 chemokine (C-C motif) ligand 2
CCL21 chemokine (C-C motif) ligand 21
CCL5 chemokine (C-C motif) ligand 5
CD44 CD44 molecule (Indian blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
COG5 component of oligomeric golgi complex 5
COL2A1 collagen, type II, alpha 1
COL6A4P1 collagen, type VI, alpha 4 pseudogene 1
COMP cartilage oligomeric matrix protein
COMT catechol-O-methyltransferase
CRP C-reactive protein, pentraxin-related
CST3 cystatin C
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSB cathepsin B
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
DEFB104A defensin, beta 104A
DEFB104B defensin, beta 104B
ENG endoglin
EPAS1 endothelial PAS domain protein 1
ESR1 estrogen receptor 1
F10 coagulation factor X
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
FAM46A family with sequence similarity 46, member A
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FSTL1 follistatin-like 1
GDF5 growth differentiation factor 5
GSTM1 glutathione S-transferase mu 1
HFE hemochromatosis
HMGB1 high mobility group box 1
ICAM1 intercellular adhesion molecule 1
IFNL1 interferon, lambda 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IHH indian hedgehog
IL18 interleukin 18
IL18R1 interleukin 18 receptor 1
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
IL6 interleukin 6
INHA inhibin, alpha
INHBA inhibin, beta A
ITLN1 intelectin 1 (galactofuranose binding)
KL klotho
LEP leptin
LEPR leptin receptor
LPAR1 lysophosphatidic acid receptor 1
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
MATN3 matrilin 3
MCF2L MCF.2 cell line derived transforming sequence-like
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NUCB2 nucleobindin 2
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PEPD peptidase D
PITX1 paired-like homeodomain 1
PLAU plasminogen activator, urokinase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNN pinin, desmosome associated protein
PON1 paraoxonase 1
PRG4 proteoglycan 4
PRKCA protein kinase C, alpha
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH parathyroid hormone
RHOB ras homolog family member B
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SREBF2 sterol regulatory element binding transcription factor 2
TGFB1 transforming growth factor, beta 1
TIMP1 TIMP metallopeptidase inhibitor 1
TLR3 toll-like receptor 3
TLR9 toll-like receptor 9
TMSB4X thymosin beta 4, X-linked
TNC tenascin C
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTR transthyretin
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
XCL2 chemokine (C motif) ligand 2