kras Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Kirsten rat sarcoma viral oncogene homolog|This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3845)
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Genes

218 genes co-occuring with the biological term kras in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABI1 abl-interactor 1
ADM adrenomedullin
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALK anaplastic lymphoma receptor tyrosine kinase
ANXA1 annexin A1
APC adenomatous polyposis coli
API5 apoptosis inhibitor 5
AR androgen receptor
AREG amphiregulin
ARHGAP35 Rho GTPase activating protein 35
AURKA aurora kinase A
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BIRC5 baculoviral IAP repeat containing 5
BMP4 bone morphogenetic protein 4
BRAF B-Raf proto-oncogene, serine/threonine kinase
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK4 cyclin-dependent kinase 4
CDK5 cyclin-dependent kinase 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CENPE centromere protein E, 312kDa
CLIC4 chloride intracellular channel 4
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTBP1 C-terminal binding protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAB2IP DAB2 interacting protein
DAPK1 death-associated protein kinase 1
DCC DCC netrin 1 receptor
DCN decorin
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DUSP4 dual specificity phosphatase 4
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EML4 echinoderm microtubule associated protein like 4
EPAS1 endothelial PAS domain protein 1
EPHA2 EPH receptor A2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
EREG epiregulin
ERH enhancer of rudimentary homolog (Drosophila)
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F3 coagulation factor III (thromboplastin, tissue factor)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FLT1 fms-related tyrosine kinase 1
GAST gastrin
GATA2 GATA binding protein 2
GLI3 GLI family zinc finger 3
GNAS GNAS complex locus
GSK3B glycogen synthase kinase 3 beta
GSTP1 glutathione S-transferase pi 1
HDAC6 histone deacetylase 6
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIC1 hypermethylated in cancer 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HRAS Harvey rat sarcoma viral oncogene homolog
HSPB1 heat shock 27kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP4 insulin-like growth factor binding protein 4
IL17A interleukin 17A
IL22 interleukin 22
IL23A interleukin 23, alpha subunit p19
IL6 interleukin 6
IQGAP1 IQ motif containing GTPase activating protein 1
IRS1 insulin receptor substrate 1
ITGB4 integrin, beta 4
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KRAS Kirsten rat sarcoma viral oncogene homolog
LIN28B lin-28 homolog B (C. elegans)
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MAX MYC associated factor X
MECOM MDS1 and EVI1 complex locus
MEN1 multiple endocrine neoplasia I
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MIR127 microRNA 127
MIR134 microRNA 134
MIR143 microRNA 143
MIR145 microRNA 145
MIR181A1 microRNA 181a-1
MIR181D microRNA 181d
MIR18A microRNA 18a
MIR193A microRNA 193a
MIR200B microRNA 200b
MIR200C microRNA 200c
MIR21 microRNA 21
MIR217 microRNA 217
MIR221 microRNA 221
MIR222 microRNA 222
MIR27A microRNA 27a
MIR30B microRNA 30b
MIR34B microRNA 34b
MIR433 microRNA 433
MIR622 microRNA 622
MIR96 microRNA 96
MIR99A microRNA 99a
MIRLET7A1 microRNA let-7a-1
MIRLET7B microRNA let-7b
MIRLET7C microRNA let-7c
MIRLET7G microRNA let-7g
MLH1 mutL homolog 1
MMP10 matrix metallopeptidase 10
MMP9 matrix metallopeptidase 9
MSH2 mutS homolog 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUTYH mutY homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOD1 myogenic differentiation 1
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NCOA4 nuclear receptor coactivator 4
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NHEJ1 nonhomologous end-joining factor 1
NKX2-1 NK2 homeobox 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NOX1 NADPH oxidase 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PAWR PRKC, apoptosis, WT1, regulator
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDPK1 3-phosphoinositide dependent protein kinase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAU plasminogen activator, urokinase
PLK1 polo-like kinase 1
PPARG peroxisome proliferator-activated receptor gamma
PRKCD protein kinase C, delta
PROM1 prominin 1
PRTN3 proteinase 3
PTCH1 patched 1
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPRJ protein tyrosine phosphatase, receptor type, J
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD21 RAD21 homolog (S. pombe)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RALB v-ral simian leukemia viral oncogene homolog B
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RB1 retinoblastoma 1
RBBP4 retinoblastoma binding protein 4
RBM5 RNA binding motif protein 5
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RET ret proto-oncogene
RHOA ras homolog family member A
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RREB1 ras responsive element binding protein 1
RRM2 ribonucleotide reductase M2
RXRA retinoid X receptor, alpha
SCRIB scribbled planar cell polarity protein
SDC1 syndecan 1
SDC2 syndecan 2
SDC4 syndecan 4
SFRP2 secreted frizzled-related protein 2
SIRT1 sirtuin 1
SIRT2 sirtuin 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SMAD4 SMAD family member 4
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SMYD3 SET and MYND domain containing 3
SNRPE small nuclear ribonucleoprotein polypeptide E
SOD1 superoxide dismutase 1, soluble
SOS1 son of sevenless homolog 1 (Drosophila)
SPHK1 sphingosine kinase 1
SSPN sarcospan
STAT5B signal transducer and activator of transcription 5B
STK11 serine/threonine kinase 11
STK3 serine/threonine kinase 3
STK33 serine/threonine kinase 33
STMN1 stathmin 1
TBK1 TANK-binding kinase 1
TERT telomerase reverse transcriptase
THRB thyroid hormone receptor, beta
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNK2 tyrosine kinase, non-receptor, 2
TNS4 tensin 4
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
TTF1 transcription termination factor, RNA polymerase I
UBE2D1 ubiquitin-conjugating enzyme E2D 1
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VMP1 vacuole membrane protein 1
WT1 Wilms tumor 1
YAP1 Yes-associated protein 1
YBX1 Y box binding protein 1