labetalol-1550 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the labetalol-1550 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSL6 acyl-CoA synthetase long-chain family member 6
ACVRL1 activin A receptor type II-like 1
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
APOL2 apolipoprotein L, 2
ARG1 arginase 1
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
BCL2A1 BCL2-related protein A1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPIFA1 BPI fold containing family A, member 1
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CD300A CD300a molecule
CD86 CD86 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DDAH2 dimethylarginine dimethylaminohydrolase 2
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DSE dermatan sulfate epimerase
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
ELK1 ELK1, member of ETS oncogene family
ENO2 enolase 2 (gamma, neuronal)
FAM13A family with sequence similarity 13, member A
FAM49A family with sequence similarity 49, member A
FCMR Fc fragment of IgM receptor
FN1 fibronectin 1
FTH1P5 ferritin, heavy polypeptide 1 pseudogene 5
GLI3 GLI family zinc finger 3
GPNMB glycoprotein (transmembrane) nmb
GPSM3 G-protein signaling modulator 3
GSR glutathione reductase
HCAR3 hydroxycarboxylic acid receptor 3
HDAC5 histone deacetylase 5
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HTRA1 HtrA serine peptidase 1
IFI16 interferon, gamma-inducible protein 16
IFI6 interferon, alpha-inducible protein 6
IGSF6 immunoglobulin superfamily, member 6
IRF7 interferon regulatory factor 7
JUN jun proto-oncogene
KDM5A lysine (K)-specific demethylase 5A
KLF13 Kruppel-like factor 13
KLF6 Kruppel-like factor 6
LINC00339 long intergenic non-protein coding RNA 339
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYO1C myosin IC
NCF1C neutrophil cytosolic factor 1C pseudogene
NDRG1 N-myc downstream regulated 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCDH17 protocadherin 17
PCIF1 PDX1 C-terminal inhibiting factor 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCD1 phospholipase C, delta 1
PLEK2 pleckstrin 2
PLIN2 perilipin 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R10 protein phosphatase 1, regulatory subunit 10
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PRRC2B proline-rich coiled-coil 2B
PTAFR platelet-activating factor receptor
RAB20 RAB20, member RAS oncogene family
RGS1 regulator of G-protein signaling 1
RGS12 regulator of G-protein signaling 12
RGS13 regulator of G-protein signaling 13
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RIN3 Ras and Rab interactor 3
RPS11 ribosomal protein S11
S100A10 S100 calcium binding protein A10
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAPER S-phase cyclin A-associated protein in the ER
SGK1 serum/glucocorticoid regulated kinase 1
SH2B1 SH2B adaptor protein 1
SH3BP2 SH3-domain binding protein 2
SIDT2 SID1 transmembrane family, member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPP1 secreted phosphoprotein 1
SUGP1 SURP and G patch domain containing 1
TBC1D22A TBC1 domain family, member 22A
TGIF1 TGFB-induced factor homeobox 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPT1 tumor protein, translationally-controlled 1
TREM1 triggering receptor expressed on myeloid cells 1

decreased expression

Symbol Name
AARSD1 alanyl-tRNA synthetase domain containing 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABT1 activator of basal transcription 1
ANKRD17 ankyrin repeat domain 17
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
ANKRD40 ankyrin repeat domain 40
AP1G1 adaptor-related protein complex 1, gamma 1 subunit
ARCN1 archain 1
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARL2 ADP-ribosylation factor-like 2
ASCC3 activating signal cointegrator 1 complex subunit 3
ASL argininosuccinate lyase
ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
BCL7B B-cell CLL/lymphoma 7B
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C10ORF2 chromosome 10 open reading frame 2
C8ORF33 chromosome 8 open reading frame 33
CBS cystathionine-beta-synthase
CDC73 cell division cycle 73
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEP85 centrosomal protein 85kDa
CHEK2 checkpoint kinase 2
CLTCL1 clathrin, heavy chain-like 1
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa
CRYZL1 crystallin, zeta (quinone reductase)-like 1
DCTPP1 dCTP pyrophosphatase 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DHDDS dehydrodolichyl diphosphate synthase
DIXDC1 DIX domain containing 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DOLPP1 dolichyldiphosphatase 1
ELANE elastase, neutrophil expressed
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP2 FK506 binding protein 2, 13kDa
FKTN fukutin
FTSJ3 FtsJ homolog 3 (E. coli)
GALT galactose-1-phosphate uridylyltransferase
GANAB glucosidase, alpha; neutral AB
GBAS glioblastoma amplified sequence
GEMIN6 gem (nuclear organelle) associated protein 6
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
INTS9 integrator complex subunit 9
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KCTD5 potassium channel tetramerization domain containing 5
LACTB2 lactamase, beta 2
LAMP5 lysosomal-associated membrane protein family, member 5
LBR lamin B receptor
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LPCAT1 lysophosphatidylcholine acyltransferase 1
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTN1 listerin E3 ubiquitin protein ligase 1
MCAT malonyl CoA:ACP acyltransferase (mitochondrial)
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha)
MCM9 minichromosome maintenance complex component 9
MCRS1 microspherule protein 1
MPV17 MpV17 mitochondrial inner membrane protein
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2
NUCLEOLIN nucleolin multifunctional protein
NXF3 nuclear RNA export factor 3
ORC2 origin recognition complex, subunit 2
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PARP1 poly (ADP-ribose) polymerase 1
PCDHGB5 protocadherin gamma subfamily B, 5
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIGT phosphatidylinositol glycan anchor biosynthesis, class T
PRDM13 PR domain containing 13
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
PRMT3 protein arginine methyltransferase 3
PRPF39 pre-mRNA processing factor 39
PSAT1 phosphoserine aminotransferase 1
PTGES2 prostaglandin E synthase 2
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
RPL23AP32 ribosomal protein L23a pseudogene 32
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
RWDD2B RWD domain containing 2B
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SMNDC1 survival motor neuron domain containing 1
SPDL1 spindle apparatus coiled-coil protein 1
TEFM transcription elongation factor, mitochondrial
THBS4 thrombospondin 4
TJP2 tight junction protein 2
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TRAPPC2L trafficking protein particle complex 2-like
TRIM28 tripartite motif containing 28
WBSCR16 Williams-Beuren syndrome chromosome region 16
WDR18 WD repeat domain 18
WDR70 WD repeat domain 70
XPO1 exportin 1
ZMYM3 zinc finger, MYM-type 3
ZNF573 zinc finger protein 573
ZNF767P zinc finger family member 767, pseudogene
ZZZ3 zinc finger, ZZ-type containing 3